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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

TUP1 Tup1p

Tup1, HIRA, Tup1p, TUPLE1
This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CAN, HAD, ACID, V1a
Papers on Tup1
Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes.
Mukai et al., Nagahama, Japan. In Biochem Biophys Res Commun, Jan 2016
The yeast Cyc8p-Tup1p complex is known to serve primarily as a transcriptional corepressor in a variety of biological processes.
KAEA (SUDPRO), a member of the ubiquitous KEOPS/EKC protein complex, regulates the arginine catabolic pathway and the expression of several other genes in Aspergillus nidulans.
Weglenski et al., Warsaw, Poland. In Gene, Jan 2016
In A. nidulans, mutations in kaeA result in several phenotypic effects, the derepression of arginine catabolism genes, and changes in the expression levels of several others, including genes involved in amino acid and siderophore metabolism, sulfate transport, carbon/energy metabolism, translation, and transcription regulation, such as rcoA(TUP1), which encodes the global transcriptional corepressor.
Continuous Histone Replacement by Hira Is Essential for Normal Transcriptional Regulation and De Novo DNA Methylation during Mouse Oogenesis.
Hajkova et al., London, United Kingdom. In Mol Cell, Dec 2015
To address the role of histone deposition in the absence of DNA replication, we deleted the H3.3 chaperone Hira in developing mouse oocytes.
Homeodomain proteins: an update.
Affolter et al., Basel, Switzerland. In Chromosoma, Nov 2015
Homologs of the co-repressor protein Groucho are also present in plants (TOPLESS), where they have been shown to interact with small amphipathic motives (EAR), and in yeast (TUP1), where we find an EH1-like motif in MATα2.
Functional Divergence of Hsp90 Genetic Interactions in Biofilm and Planktonic Cellular States.
Cowen et al., Toronto, Canada. In Plos One, 2014
Here, we explored the relationship between Hsp90 and five of these transcription factor genetic interactors: BCR1, MIG1, TEC1, TUP1, and UPC2.
Adherence of Candida sp. to host tissues and cells as one of its pathogenicity features.
Kurnatowski et al., Łódź, Poland. In Ann Parasitol, 2014
Various researchers specify a range of genes which contribute to adhesion, such as: CZF1, EFG1, TUP1, TPK1, TPK2, HGC1, RAS1, RIM101, VPS11, ECM1, CKA2, BCR1, BUD2, RSR1, IRS4, CHS2, SCS7, UBI4, UME6, TEC1 and GAT2.
Live detection and purification of cells based on the expression of a histone chaperone, HIRA, using a binding peptide.
Maliekal et al., Thiruvananthapuram, India. In Sci Rep, 2014
The target molecule selected was a histone chaperone, HIRA, the expression of which can predict the fate of differentiating myoblast.
Gearing up chromatin: A role for chromatin remodeling during the transcriptional restart upon DNA damage.
Marteijn et al., Rotterdam, Netherlands. In Nucleus, 2014
Recently, three different chromatin remodeling factors, HIRA, FACT, and Dot1L, were identified to stimulate transcription restart after DNA damage.
Histone H3 dynamics in plant cell cycle and development.
Gutierrez et al., Madrid, Spain. In Cytogenet Genome Res, 2013
We also include a discussion on the histone H3 chaperones that actively participate in H3 deposition, in particular CAF-1, HIRA and ASF1, and on the putative plant homologs of human ATRX and DEK chaperones.
Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells.
Allis et al., New York City, United States. In Cell, 2013
Further, we show H3.3-dependent interaction of PRC2 with the histone chaperone, Hira, and that Hira localization to chromatin requires H3.3.
Transcription recovery after DNA damage requires chromatin priming by the H3.3 histone chaperone HIRA.
Almouzni et al., Paris, France. In Cell, 2013
Here, by investigating how chromatin dynamics regulate transcriptional activity in response to DNA damage in human cells, we identify a pathway involving the histone chaperone histone regulator A (HIRA) to promote transcription restart after UVC damage.
A global requirement for the HIR complex in the assembly of chromatin.
Prochasson et al., Kansas City, United States. In Biochim Biophys Acta, 2013
In this review, we discuss the roles of an evolutionarily conserved histone chaperone known as the HIR/HIRA complex.
Crystal structure of the N-terminal domain of the yeast general corepressor Tup1p and its functional implications.
Mukai et al., Suita, Japan. In J Biol Chem, 2012
data presented herein highlight the importance of the architecture of the Tup1p N-terminal domain for self-association
Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex.
Marmorstein et al., Philadelphia, United States. In Biochemistry, 2012
NHRD domain of UBN1 as being an essential region for HIRA interaction and chromatin organization by the HUCA complex
The Cyc8-Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein.
Struhl et al., Boston, United States. In Genes Dev, 2012
Cyc8-Tup1 regulates transcription primarily by masking and inhibiting the transcriptional activation domains of the recruiting proteins, not by acting as a corepressor
Tup1 stabilizes promoter nucleosome positioning and occupancy at transcriptionally plastic genes.
Buck et al., Buffalo, United States. In Nucleic Acids Res, 2011
Analysis of wild-type and tup1 Delta chromatin data sets revealed unique organizational themes relating to the function of Tup1.
Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.
Adams et al., Bearsden, United Kingdom. In Mol Cell Biol, 2011
Data show that, like HIRA, UBN1, and ASF1a, CABIN1 is involved in heterochromatinization of the genome of senescent human cells.
Distinct factors control histone variant H3.3 localization at specific genomic regions.
Allis et al., New York City, United States. In Cell, 2010
The H3.3 chaperone Hira is required for H3.3 enrichment at active and repressed genes.
CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo.
Fyodorov et al., United States. In Science, 2007
Furthermore, CHD1, but not ISWI, interacts with HIRA in cytoplasmic extracts.
Multiple rounds of speciation associated with reciprocal gene loss in polyploid yeasts.
Wolfe et al., Dublin, Ireland. In Nature, 2006
For example, several transcription factor genes, including STE12, TEC1, TUP1 and MCM1, are single-copy in S. cerevisiae but are retained in duplicate in S. castellii and C. glabrata.
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