gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Fragile histidine triad gene

Tumor Suppressor Protein
This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: vascular endothelial growth factor, T is, E2F1, ACID, pRb
Papers on Tumor Suppressor Protein
The Retinoblastoma Tumor Suppressor Protein (pRb)/E2 Promoter Binding Factor 1 (E2F1) Pathway as a Novel Mediator of Transforming Growth Factor-β (TGFβ)-Induced Autophagy.
Lebrun et al., Canada. In J Biol Chem, Dec 2015
We found that autophagosome initiation and maturation by TGFβ is dependent on the retinoblastoma tumor suppressor protein/E2 promoter binding factor (pRb/E2F1) pathway, which we have previously established as a critical signaling axis leading to various TGFβ tumor suppressive effects.
The expression of FHIT in salivary carcinoma ex pleomorphic adenoma.
Sloan et al., Riyadh, Saudi Arabia. In Anticancer Res, 2012
we found that nuclear FHIT expression could be used as a good marker to distinguish PSA from Ca-ex-PA
Inactivation of both FHIT and p53 cooperate in deregulating proliferation-related pathways in lung cancer.
Roz et al., Milano, Italy. In J Thorac Oncol, 2012
transcriptional deregulation after FHIT modulation was higher in p53-negative cells
The promoter hypermethylation status of GATA6, MGMT, and FHIT in glioblastoma.
Tolunay et al., Bursa, Turkey. In Cell Mol Neurobiol, 2012
The methylation status at the promoter regions of GATA6, MGMT, and FHIT in glioblastoma, was examined.
The significance of fragile histidine triad protein as a molecular prognostic marker of bladder urothelial carcinoma.
Xu et al., Tianjin, China. In J Int Med Res, 2011
There was a significant association between negative FHIT expression in bladder urothelial carcinoma and advanced tumour stage, high pathological grade, large tumour size, tumour recurrence and reduced survival time.
Aberrant FHIT expression is linked to bladder carcinogenesis and apoptosis.
Kong et al., Shenyang, China. In Asian Pac J Cancer Prev, 2010
role of FHIT expression in bladder carcinogenesis and progression; FHIT was expressed in carcinoma and adjacent normal tissues at mRNA and protein levels, but 17 kDa FHIT was lower in tumors; negative correlation between FHIT expression and histological grade of bladder transitional cell carcinoma but no clear relationship with stage or relapse
The von Hippel-Lindau Tumor Suppressor Protein Is Destabilized by Src: Implications for Tumor Angiogenesis and Progression.
Fujita et al., Calgary, Canada. In Genes Cancer, 2010
The von Hippel-Lindau tumor suppressor protein (VHL), when mutated and inactivated, has been associated with renal and CNS cancer development.
Association of Tumor Suppressor Protein Pdcd4 With Ribosomes Is Mediated by Protein-Protein and Protein-RNA Interactions.
Klempnauer et al., Münster, Germany. In Genes Cancer, 2010
The Pdcd4 (programmed cell death gene 4) gene has been implicated as a novel tumor suppressor gene in the development of several types of human cancer.
share on facebooktweetadd +1mail to friends