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Tubulin, alpha 3c

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% identical to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: alpha-tubulin, ACID, V1a
Papers on TUBA2
Microtubule and male sterility in a gene-cytoplasmic male sterile line of non-heading Chinese cabbage.
Hou et al., Nanjing, China. In J Sci Food Agric, 2012
RESULTS: α-Tubulin gene TUBA2 from non-heading Chinese cabbage (Brassica campestris ssp.
A radiation hybrid map of 48 loci including the clouston hidrotic ectodermal dysplasia locus in the pericentromeric region of chromosome 13q.
Rouleau et al., Montréal, Canada. In Genomics, 1999
This map spans 347 cR9000, has an average resolution of 17.3 cR9000, and includes 3 genes (TUBA2, GJbeta2, and FGF-9), 18 ESTs, 19 polymorphic loci, and 8 single-copy DNA segments.
Sequence characterization of a newly identified human alpha-tubulin gene (TUBA2).
Petit et al., Paris, France. In Genomics, 1998
We report on the isolation and initial characterization of a human alpha-tubulin gene named TUBA2.
A YAC contig and an EST map in the pericentromeric region of chromosome 13 surrounding the loci for neurosensory nonsyndromic deafness (DFNB1 and DFNA3) and limb-girdle muscular dystrophy type 2C (LGMD2C).
Cohen et al., Paris, France. In Genomics, 1995
Eight expressed sequence tags, previously assigned to 13q11-q12 (D13S182E, D13S183E, D13S502E, D13S504E, D13S505E, D13S837E, TUBA2, ATP1AL1), were localized on the YAC contig.
Characterization of a mutant Leishmania donovani deficient in adenosine kinase activity.
Ullman et al., In Mol Biochem Parasitol, 1984
From a mutagenized population of wildtype Leishmania donovani promastigotes, a clonal cell line, TUBA2, was isolated by virtue of its ability to survive and grow in 20 microM tubercidin (7-deazaadenosine).
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