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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

NK2 homeobox 1

TTF-1, thyroid transcription factor-1, Nkx2.1
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Apr 2011] (from NCBI)
Top mentioned proteins: TTF, cytokeratin, HAD, CAN, p63
Papers using TTF-1 antibodies
Differential diagnosis of primary versus metastatic pulmonary adenocarcinomas using gene mutation analyses: a case report
Allan Robert W. et al., In Case Reports in Pathology, 2007
These included thyroid transcription factor-1 (TTF-1, 8G7G3/1 clone, Cell Marque, Rocklin, CA, USA), cytokeratin ...
Features of benign granular cell tumor on fine needle aspiration
Jhala Darshana N et al., In CytoJournal, 1998
... detect the following antibodies: S-100 (Ventana; predilute), CD68 (Ventana; predilute), thyroglobulin (Cell marque; predilute), and TTF-1 (Dako; 1:50) ...
Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression.
Yang Chengfeng et al., In Environmental Health Perspectives, 1996
... Anti-thyroid transcription factor 1 (anti-TTF-1; sc-13040) primary antibody was obtained from Santa Cruz Biotechnology.
Architecture of the human lung. Use of quantitative methods establishes fundamental relations between size and number of lung structures
Snyder Brian D. et al., In Clinical Orthopaedics and Related Research, 1961
... TTF-1Type II pneumocytesDAKO, Carpinteria, CA (M3575) ...
Papers on TTF-1
Peritoneal malignant mesothelioma (PMM), and primary peritoneal serous carcinoma (PPSC) and reactive mesothelial hyperplasia (RMH) of the peritoneum. Immunohistochemical and fluorescence in situ hybridisation (FISH) analyses.
Hiroshima et al., Tokorozawa, Japan. In J Clin Pathol, Feb 2016
METHODS: To help differentiate PMM from PPSC and RMH, we used immunohistochemistry to examine mesothelial-associated markers (calretinin, AE1/AE3, CK5/6, CAM5.2, D2-40, WT-1, HBME1, thrombomodulin), adenocarcinoma-associated markers (CEA, BerEP4, MOC31, ER (estrogen receptor), PgR, TTF-1, Claudin-4, Pax8), and malignant-related and benign-related markers (epithelial membrane antigen (EMA), desmin, GLUT-1, CD146 and IMP3), and FISH to examine for homozygous deletion of 9p21.
Small Cell Carcinoma of the Urinary Bladder: KIT and PDGFRA Gene Mutations.
Kozacioğlu et al., İzmir, Turkey. In Rare Tumors, Jan 2016
The tumor cells were negative for CK7, CK20, CD3, CD20, LCA, CDX2, uroplakin, thyroid transcription factor 1, PSA and p63.
[Bilateral Pneumothorax due to Pulmonary Metastasis from Angiosarcoma of the Forehead;Report of a Case].
Yamamoto et al., Itami, Japan. In Kyobu Geka, Dec 2015
These cells were cluster differentiation(CD)31 and CD34 positive and negative for calretinin, cytokeratin, carcinoembryonic antigen (CEA), thyroid transcription factor(TTF-1)and epithelial membrane antigen(EMA).
Comparison of immunohistochemistry and mRNA in situ hybridization in detecting thyroid transcription factor-1 expression in non-small cell lung carcinomas tissue.
Zhang et al., Shenyang, China. In Oncol Lett, Dec 2015
UNASSIGNED: Thyroid transcription factor-1 (TTF-1) reportedly possesses oncogenic and suppressive roles within the same tumor type and may play a dual function in the progression of lung cancer.
Mucinous Variant of Follicular Carcinoma of the Thyroid Gland: Case Report and Review of the Literature.
Cosimi et al., Novi Ligure, Italy. In Int J Surg Pathol, Dec 2015
We report the fourth case of mucinous variant of follicular carcinoma displaying a minimally invasive tumor with diffuse expression of thyroglobulin, TTF-1, CD56, PAX-8, cytokeratins 7 and 19, in the absence of monoclonal carcinoembryonic antigen (CEA), cytokeratin 20, chromogranin, HBME-1, P63 expression, and BRAF gene mutation, in a 51-year-old woman who is alive without signs of disease 13 months after total thyroidectomy, bilateral neck dissection, and radioactive iodine.
Thyroid-like follicular carcinoma of the kidney: one case report and review of the literature.
Nodit et al., Pittsburgh, United States. In Am J Clin Pathol, Nov 2015
Our goal is to expand the knowledge of this rare renal cell carcinoma subtype, which is morphologically similar to follicular carcinoma of the thyroid but lacks expression of characteristic thyroid immunohistochemical markers such as TTF-1 and thyroglobulin.
Thyroid Paraganglioma.
Policarpio-Nicolas et al., San Antonio, United States. In Arch Pathol Lab Med, Aug 2015
Immunohistochemical stains (cytokeratin, parathyroid hormone, thyroid transcription factor 1, tyrosine hydroxylase, chromogranin A, synaptophysin, S100, calcitonin, carcinoembryonic antigen) are essential in establishing the diagnosis.
Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy.
Sang et al., Nanjing, China. In An Bras Dermatol, May 2015
They were stained positive for villin, CDX-2, CKpan (AE1/ AE3), CEA, CK8/18, CK19, CK7, EMA, Ki-67 (50%), and negative for S-100, CK20, CD34, GCDFP-15 and TTF-1.
A rare case of pulmonary sclerosing hemagioma with lymph node metastasis and review of the literature.
Zhang et al., Hangzhou, China. In Int J Clin Exp Pathol, 2014
Immunohistochemistry (IHC) revealed that both surface-lining cuboidal and polygonal cells expressed EMA and thyroid transcription factor 1 (TTF-1), but were negative for CD34, VIII factor, CD68 and Claratinin.
Numerous osteoclast-like giant cells in metastases from lung adenocarcinoma, but absent from primary tumor.
Sato et al., Tokyo, Japan. In Thorac Cancer, 2014
Primary lung carcinoma cells were positive for cytokeratin 7 (CK7), epithelial membrane antigen (EMA), thyroid transcription factor 1 (TTF-1), and Napsin A, but were negative for vimentin and CD68.
Maintenance therapy for advanced lung cancer: who, what, and when?
Gerber, Dallas, United States. In J Clin Oncol, 2013
Immunohistochemical stains were positive for napsin A and thyroid transcription factor 1, suggestive of adenocarcinoma (Fig 1).
NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression.
Takahashi et al., Nagoya, Japan. In Cancer Cell, 2013
Emerging evidence indicates that NKX2-1, a homeobox-containing transcription factor also known as TTF-1, plays a role as a "lineage-survival" oncogene in lung adenocarcinomas.
Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.
Studer et al., New York City, United States. In Cell Stem Cell, 2013
Here, we demonstrate the highly efficient derivation of human cortical interneurons in an NKX2.1::GFP human embryonic stem cell reporter line.
Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits.
Zhang et al., Madison, United States. In Nat Biotechnol, 2013
Here we present a method for differentiating human embryonic stem cells (hESCs) to a nearly uniform population of NKX2.1(+)
Occludin is a direct target of thyroid transcription factor-1 (TTF-1/NKX2-1).
Mu et al., United States. In J Biol Chem, 2012
TTF-1 transcriptionally regulates occludin, which represents another avenue of TTF-1-mediated metastasis suppression
Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression.
Ojeda et al., Beaverton, United States. In J Neuroendocrinol, 2012
TTF1 contributes to regulating periodic oscillations in expression of the gonadotrophin-releasing hormone (GnRH) gene expression; TTF1 transactivates GnRH transcription by binding to two sites in the GnRH promoter.
Opposite roles of FOXA1 and NKX2-1 in lung cancer progression.
Wikman et al., Hamburg, Germany. In Genes Chromosomes Cancer, 2012
Assessed gene amplifications and protein expression of NKX2-1 and FOXA1 in primary lung tumors (n = 554) and brain metastases (n = 68).
Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs.
Rajagopal et al., Boston, United States. In Cell Stem Cell, 2012
Definitive endoderm derived from mouse embryonic stem cells (ESCs) was converted into foregut endoderm, then into replicating Nkx2.1+ lung endoderm, and finally into multipotent embryonic lung progenitor and airway progenitor cells.
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.
Takahashi et al., Nagoya, Japan. In Cancer Cell, 2012
NKX2-1 induces the expression of the receptor tyrosine kinase-like orphan receptor 1 (ROR1), which in turn sustains a favorable balance between prosurvival PI3K-AKT and pro-apoptotic p38 signaling.
Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors.
Ramirez et al., Boston, United States. In Plos One, 2011
Expression levels of Nkx2-1 direct target genes identified in mouse development significantly correlate or anti-correlate to the levels of endogenous NKX2-1 in a dosage-dependent manner in multiple human lung tumor expression data sets.
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