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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Tetratricopeptide repeat domain 3

Top mentioned proteins: CAN, Ubiquitin, ACID, DYRK1A, OUT
Papers on TTC3
Expression and purification of the natively disordered and redox sensitive metal binding regions of Mycobacterium tuberculosis protein kinase G.
Dames et al., Garching bei München, Germany. In Protein Expr Purif, Jul 2015
The catalytic domain (∼147-405) is C-terminally flanked by a tetratricopeptide repeat domain (TPRD).
Prevalence of chromosomal rearrangements involving non-ETS genes in prostate cancer.
Minner et al., Hamburg, Germany. In Int J Oncol, Apr 2015
Recurrent breakage, often accompanied by partial deletion of the genes, was found for NCKAP5, SH3BGR and TTC3 in 3 (0.8%) tumors each, as well as for ARNTL2 and ENOX1 in 2 (0.5%) cancers each.
A mechanism for asymmetric cell division resulting in proliferative asynchronicity.
Ramaswamy et al., Boston, United States. In Mol Cancer Res, Feb 2015
In addition, evidence indicates that the proliferative output of this signaling cascade involves a proteasome-dependent degradation process mediated by the E3 ubiquitin ligase TTC3.
Screening of human chromosome 21 genes in the dorsolateral prefrontal cortex of individuals with Down syndrome.
Jiang et al., Zhengzhou, China. In Mol Med Report, Feb 2015
Furthermore, 17 overexpressed genes were identified on the 21q21‑22 area, including COL6A2, TTC3 and ABCG1.
Rapid detection of Down's syndrome using quantitative real-time PCR (qPCR) targeting segmental duplications on chromosomes 21 and 11.
Lao et al., Qinzhou, China. In Gene, 2015
METHODS: Segmental duplications in the TTC3 gene on chromosome 21 and the KDM2A gene on chromosome 11 were selected as molecular markers for the diagnostic qPCR assay.
Bioinformatics analysis of biomarkers and transcriptional factor motifs in Down syndrome.
Xu et al., Zhengzhou, China. In Braz J Med Biol Res, 2014
CBR1, DYRK1A, HMGN1, ITSN1, RCAN1, SON, TMEM50B, and TTC3 were each up-regulated two-fold in Down syndrome samples compared to normal samples; of these, SON and TTC3 were newly reported.
The DCR protein TTC3 affects differentiation and Golgi compactness in neurons through specific actin-regulating pathways.
Di Cunto et al., Torino, Italy. In Plos One, 2013
In this report we show that high levels of the TTC3 protein, encoded by one of the genes of the Down Syndrome Critical Region (DCR), prevent neurite extension and disrupt Golgi compactness in differentiating primary neurons.
Commonality in Down and fetal alcohol syndromes.
Roper et al., Indianapolis, United States. In Birth Defects Res A Clin Mol Teratol, 2013
Further mechanistic studies suggested overexpression of trisomic Ttc3 in DS embyros may influence nuclear pAkt localization and cell survival.
Analysis of altered gene expression specific to embryotoxic chemical treatment during embryonic stem cell differentiation into myocardiac and neural cells.
Saito et al., Ōsaka, Japan. In J Toxicol Sci, 2011
Of the 107 genes up-regulated under differentiation into neurons, 22 genes (Map2, Cpe, Marcks, Ptbp2, Sox11, Tubb2b, Vim, Arx, Emx2, Pax6, Basp1, Ddr1, Ndn, Sfrp, Ttc3, Ubqln2, Six3, Dcx, L1cam, Reln, Wnt1 and Nnat) showed reduced expression specifically by embryotoxic chemicals.
Cigarette smoke induces Akt protein degradation by the ubiquitin-proteasome system.
Lee et al., Suwŏn, South Korea. In J Biol Chem, 2011
Of note, CSE induced expression of the tetratrico-peptide repeat domain 3 (TTC3), known as a ubiquitin ligase for active Akt.
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.
Noguchi et al., Sapporo, Japan. In Dev Cell, 2009
Interaction between TTC3 and Akt may contribute to the clinical symptoms of Down syndrome.
TTC3 ubiquitination terminates Akt-ivation.
Toker, Boston, United States. In Dev Cell, 2009
They show that the E3 ubiquitin ligase TTC3 modifies phosphorylated and activated Akt and thereby promotes its degradation by the proteasome in the nucleus.
Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays.
Prehn et al., Dublin, Ireland. In Biochim Biophys Acta, 2009
Novel polyubiquitin binders AWP1, CALCOCO2, N4BP1, RIO3, TEX27, TTC3, UBFD1 and ZNF313 were identified using this approach, while known NF-kappaB regulators including NEMO, A20, ABIN-1, ABIN-2, optineurin and p62 were also identified.
Gene expression patterns of hippocampus and cerebral cortex of senescence-accelerated mouse treated with Huang-Lian-Jie-Du decoction.
Zhang et al., Beijing, China. In Neurosci Lett, 2008
The results showed that HL has the significant modulating effects on age-related changes of the gene expressions in the hippocampus and cerebral cortex in SAMP8, which include genes that involved in signal transduction (Dusp12, Rps6ka1, Rab26, Penk1, Nope, Leng8, Syde1, Phb, Def8, Ihpk1, Tac2, Pik3c2a), protein metabolism (Ttc3, Amfr, Prr6, Ube2d2), cell growth and development (Ngrn, Anln, Dip3b, Acrbp), nucleic acid metabolism (Fhit, Itm2c, Cstf2t, Ddx3x, Ercc5, Pcgfr6), energy metabolism (Stub1, Uqcr, Nsf), immune response (C1qb), regulation of transcription (D1ertd161e, Gcn5l2, Ssu72), transporter (Slc17a7, mt-Co1), nervous system development (Trim3), neurogila cell differentiation (Tspan2) and 24 genes whose biological function and process were still unknown.
The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.
Di Cunto et al., Torino, Italy. In J Cell Sci, 2007
These results suggest that the TTC3-RhoA-CIT-K pathway could be a crucial determinant of in vivo neuronal development, whose hyperactivity may result in detrimental effects on the normal differentiation program.
Dysregulation of growth factor receptor-bound protein 2 and fascin in hippocampus of mice polytransgenic for chromosome 21 structures.
Lubec et al., Vienna, Austria. In Hippocampus, 2006
Nonchimeric polytransgenic 152F7 mice encompassing four human chromosome 21 genes (DSCR3, DSCR5, TTC3, and DYRK1A) within the Down syndrome critical region present with learning and memory impairment.
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