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Tetraspanin 5

Tspan-5, Tetraspanin-5, Tm4sf9, tetraspanin Tspan-5, tetraspan NET-4, mTspan-5
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: Tetraspanin, CD53, CD63, NET, CD151
Papers on Tspan-5
Downregulation of Notch modulators, tetraspanin 5 and 10, inhibits osteoclastogenesis in vitro.
Zhao et al., Shanghai, China. In Calcif Tissue Int, 2014
In this in vitro study, we have provided evidence that two of the TspanC8 subfamily members of tetraspanins, Tspan-5 and Tspan-10, are up-regulated during osteoclast differentiation and knockdown of their expression by shRNAs dramatically inhibits osteoclastogenesis.
Expression of the tetraspanin family members Tspan3, Tspan4, Tspan5 and Tspan7 during Xenopus laevis embryonic development.
Nazarenko et al., Karlsruhe, Germany. In Gene Expr Patterns, 2013
Here, we examined the spatial and temporal gene expression of four related tetraspanins during the embryonic development of Xenopus laevis by quantitative real-time PCR and in situ hybridization: Tspan3 (encoded by the gene Tm4sf8 gene) Tspan4 (encoded by the gene Tm4sf7), Tspan5 (encoded by the gene Tm4sf9) and Tspan7 (encoded by the gene Tm4sf2).
Expression and function of transmembrane-4 superfamily (tetraspanin) proteins in osteoclasts: reciprocal roles of Tspan-5 and NET-6 during osteoclastogenesis.
Saeki et al., Ōsaka, Japan. In Allergol Int, 2007
Up-regulated in pre-osteoclasts during cell differentiation.
Identification of eight genes that are potentially involved in tamoxifen sensitivity in breast cancer cells.
Han et al., Los Angeles, United States. In Cell Res, 2005
Retinol binding protein 7, DNA polymerase-transactivated protein 3, g-glutamyltransferase-like activity 1, slit-robo RhoGTPase-activating protein, tetraspan NET-4, HSPC194, amiloride-sensitive epithelial sodium channel gene, and Notch2, were the eight mutated genes identified in different tamoxifen resistant clones, suggesting their requirement for tamoxifen sensitivity in ZR-75-1 cells.
Tetraspanin-5 (Tm4sf9) mRNA expression parallels neuronal maturation in the cerebellum of normal and L7En-2 transgenic mice.
Baader et al., Bonn, Germany. In J Comp Neurol, 2005
The level of Tspan-5 expression might be important for distinct phases of neuronal maturation.
Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential.
Strominger et al., Cambridge, United States. In J Exp Med, 2003
The largest number of these encoded surface proteins, including the unusual lectinlike receptors NKG2E and Ly-49L, several killer cell Ig-like receptors, the integrin subunits alpha(D), alpha(X), beta1, and beta5, and multiple tetraspanins (CD9, CD151, CD53, CD63, and TSPAN-5).
Pattern of expression of the tetraspanin Tspan-5 during brain development in the mouse.
Soriano et al., Barcelona, Spain. In Mech Dev, 2001
This protein is expressed during brain development from embryonic stages to adulthood.
Molecular anatomy of an intracranial aneurysm: coordinated expression of genes involved in wound healing and tissue remodeling.
Brufsky et al., Pittsburgh, United States. In Stroke, 2001
Specifically, we observed significant overexpression of genes encoding extracellular matrix components (eg, COL3A1, COL1A1, COL1A2, COL6A1, COL6A2, elastin) and genes involved in extracellular matrix turnover (TIMP-3, OSF-2), cell adhesion and antiadhesion (SPARC, hevin), cytokinesis (PNUTL2), and cell migration (tetraspanin-5).
Mouse Tspan-5, a member of the tetraspanin superfamily, is highly expressed in brain cortical structures.
Soriano et al., Barcelona, Spain. In Neuroreport, 2000
Using a subtractive hybridization method for the identification of genes related to the development of the murine cerebral cortex, we cloned a mouse homologue of a human tetraspanin family member, Tspan-5.
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