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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Tetraspanin 2

TSPAN-2, tetraspanin-2
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Tetraspanin, TSP2, Insulin, Phosphogluconate Dehydrogenase, OUT
Papers on TSPAN-2
Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis.
Chanalaris et al., Oxford, United Kingdom. In Osteoarthritis Cartilage, Apr 2015
Common genes include Jagged 1 (Jag1), Tetraspanin 2 (Tspan2), neuroblastoma, suppression of tumourigenicity 1 (Nbl1) and N-myc downstream regulated gene 2 (Ndrg2).
DNA Vaccine Encoding the Chimeric Form of Schistosoma mansoni Sm-TSP2 and Sm29 Confers Partial Protection against Challenge Infection.
Oliveira et al., Belo Horizonte, Brazil. In Plos One, 2014
Sm29 and tetraspanin-2 (Sm-TSP2) are two proteins that are located in the S. mansoni tegument of adult worms and schistosomula and induce high levels of protection through recombinant protein immunization.
Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2.
Werner et al., Göttingen, Germany. In Glia, 2013
Here, we demonstrate that the abundance of the structurally related tetraspanin-2 (TSPAN2) is highly increased in CNS myelin of Plp1(null) -mice.
Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine.
Olesen et al., Copenhagen, Denmark. In Eur J Neurol, 2013
In addition, the C-allele of rs2078371 (near TSPAN-2) also reached genome-wide significance for association with migraine [OR = 1.14;
Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene.
Cunningham et al., Albuquerque, United States. In Int J Parasitol, 2011
Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice.
Inconsistent protective efficacy and marked polymorphism limits the value of Schistosoma japonicum tetraspanin-2 as a vaccine target.
McManus et al., Brisbane, Australia. In Plos Negl Trop Dis, 2010
BACKGROUND: Schistosoma mansoni tetraspanin 2 (Sm-TSP-2) has been shown to be strongly recognized by IgG1 and IgG3 antibodies from individuals putatively resistant to schistosome infection, but not chronically infected people, and to induce high levels of protection against challenge infection in the murine model of schistosomiasis.
The secreted and surface proteomes of the adult stage of the carcinogenic human liver fluke Opisthorchis viverrini.
Loukas et al., Australia. In Proteomics, 2010
These included annexins, which are potential immuno-modulators, and orthologues of the schistosomiasis vaccine antigens Sm29 and tetraspanin-2.
Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism.
Lisanti et al., Philadelphia, United States. In Cell Cycle, 2008
We observed a 4-fold increase in tetraspanin-2 gene expression, a transmembrane protein implicated in regulating intracellular trafficking.
Molecular characterization of Schistosoma japonicum tegument protein tetraspanin-2: sequence variation and possible implications for immune evasion.
Wang et al., Beijing, China. In Biochem Biophys Res Commun, 2008
In this work, we were surprised to identify seven tetraspanin-2 (TSP-2) homologs of the protective antigen Sm-TSP-2 in Schistosoma japonicum and found that the transcription profiles of Sj-tsp-2 subclasses were highly variable in individual adult worms.
[Cloning, expression and identification of membrane protein Tetraspanin 2-A of Schistosoma japonicum].
Shen et al., Hefei, China. In Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi, 2008
OBJECTIVE: To clone and express a membrane protein (Tetraspanin 2) gene of Schistosoma japonicum (SjTsp2).
Identification of differentially expressed genes induced by angiotensin II in rat cardiac fibroblasts.
Bai et al., Xi'an, China. In Clin Exp Pharmacol Physiol, 2006
Sequencing of the partially enriched cDNAs identified 36 genes differentially expressed, including ECM proteins (pro-alpha(1) collagen type III, fibronectin), structural protein (spectrin), enzyme (GTP-specific succinyl-CoA synthetase), transcriptional regulators (glucocorticoid-induced leucine zipper, inhibitor of DNA binding 3) and proteins involved in cell division control (cdc2) or cell signalling (insulin-like growth factor binding protein-3, mutant p53-binding protein, grp75, CGI-121, protein phosphatase type 2A, tspan-2 and Sam68).
Identification of 20 genes aberrantly methylated in human breast cancers.
Ushijima et al., Tokyo, Japan. In Int J Cancer, 2005
CGI in 5' upstream regions of 20 genes, TSPAN-2, AK5, LOC284999, HOXD11, FLJ25161, XT3, PCDH10, PCDHGB6, SIM1, LOC346978, COE2, TDH (FLJ25033), LOC346419, FLJ33790, GJB2, AMN, LOC201164, DLX4, DCC and FOXA2, were found to be methylated in at least one of 8 breast cancer cell lines.
Potential markers of tongue tumor progression selected by cDNA microarray.
Pezzetti et al., Ferrara, Italy. In Int J Immunopathol Pharmacol, 2005
Among potential markers of metastases are some genes related to cell mobility (TSPAN-2 and SNTA1), intercellular adhesion (integrin alpha 7) or extracellular matrix components (ADAMTS2 and cathepsin O).
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