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Testis-specific serine kinase 2

Tsk2, TSSK2, tight skin 2
TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Tsk1, clone 4, SSTK, CAN, AGE
Papers on Tsk2
Recombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2.
Herr et al., Charlottesville, United States. In Protein Expr Purif, Feb 2016
UNASSIGNED: The testis-specific serine/threonine kinase 2 (TSSK2) has been proposed as a candidate male contraceptive target.
Cloning, sequence characterization, and expression patterns of members of the porcine TSSK family.
Xiao et al., Kunming, China. In Genet Mol Res, 2014
Following comparison with TSSK4 genes in other species, BMI TSSK4 was found to contain three alternatively spliced variants, inform1, inform 3, and inform 4. BMI TSSK1 and TSSK2 are co-localized on the Sus scrofa chromosome (SSC) 14, and consist of a single exon; TSSK3, TSSK4, and TSSK6 are on SSC6, SSC7, and SSC2, and consist of two, four, and one exon, respectively.
Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis.
Blankenhorn et al., Philadelphia, United States. In Matrix Biol, 2014
The tight skin 2 (Tsk2) mouse model of systemic sclerosis (SSc) has many features of the human disease including tight skin, fibrosis, extracellular matrix abnormalities, and reported antinuclear antibodies (ANA).
Heat shock protein 90 functions to stabilize and activate the testis-specific serine/threonine kinases, a family of kinases essential for male fertility.
Johnson et al., Bethesda, United States. In J Biol Chem, 2013
Using specific antibodies against murine TSSK2 and -6, it was demonstrated that HSP90 inhibition resulted in a marked decrease of the endogenous kinases in spermatids.
Testis specific serine/threonine kinase 4 (Tssk4) maintains its kinase activity by phosphorylating itself at Thr-197.
Yu et al., Shanghai, China. In Mol Biol Rep, 2013
In present work, we generate a polyclonal antibody which specifically recognizes Tssk4 but not the other three Tssk family members (Tssk1, Tssk2 and Tssk3).
Evolution of testis-specific kinases TSSK1B and TSSK2 in primates.
Grootegoed et al., Rotterdam, Netherlands. In Andrology, 2013
The testis-specific serine/threonine protein kinases TSSK1 and TSSK2 are known to be essential for male fertility, in mice.
[Cloning and expression of Tssk1 & Tssk2 in mice and the presence & localization of them in mature sperm].
Li et al., Kunming, China. In Dongwuxue Yanjiu, 2012
Purified Tssk proteins were obtained based on cloning and expression of mouse Tssk1 and Tssk2.
Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis.
Salicioni et al., Amherst Center, United States. In Mol Hum Reprod, 2011
Immunolocalization in mouse testis, and in mouse and human sperm, showed that Tssk1, Tssk2, Tssk4 and Tssk6, but not Tssk3, were present in mouse sperm and in germ cells from mouse testis.
Some single-nucleotide polymorphisms of the TSSK2 gene may be associated with human spermatogenesis impairment.
Zhang et al., Chengdu, China. In J Androl, 2010
associated with male idiopathic infertility
Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases.
Grootegoed et al., Rotterdam, Netherlands. In J Cell Sci, 2010
Results reveal TSSK1- and TSSK2-dependent functions of a transformed chromatoid body in post-meiotic cytodifferentiation of spermatids.
Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells.
Grueneberg et al., Boston, United States. In Proc Natl Acad Sci U S A, 2008
These kinases include CDK6, ERBB3, FYN, AAK1, and TSSK2.
Animal models in systemic sclerosis.
Matucci Cerinic et al., Florence, Italy. In Clin Exp Rheumatol, 2008
In one group the pathologic phenotype is the result of a genetic mutation ( tight skin 1 and tight skin 2,UCD 200).
TSKS concentrates in spermatid centrioles during flagellogenesis.
Herr et al., Charlottesville, United States. In Dev Biol, 2008
Deletion of Tssk2 kinase/substrate pair is predicted to play an indispensable role during spermiogenesis.
Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency.
Herr et al., Charlottesville, United States. In Dev Biol, 2008
TSSK1 and TSKS persist in sperm, define a critical role of TSKS' N-terminus in enzyme interaction, identify Ser 281 as a TSKS phosphorylation site and indicate an indispensable role for TSSK 1 and 2 in spermiogenesis.
Phosphorylation of mouse sperm axoneme central apparatus protein SPAG16L by a testis-specific kinase, TSSK2.
Strauss et al., Richmond, United States. In Biol Reprod, 2008
SPAG16L can be phosphorylated by TSSK2 in vitro.
Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets.
Herr et al., Charlottesville, United States. In Soc Reprod Fertil Suppl, 2006
In situ hybridization further confirmed that mouse TSSK2, SSTK and TSKS are post-meiotic in their expression patterns, a finding that makes them possible targets of reversible contraceptive intervention by preserving spermatogonia and spermatocytes.
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