gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Transient receptor potential cation channel, subfamily M, member 6

This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: TRPM7, melastatin, V1a, TRPV5, CAN
Papers on TRPM6
Clinical presentation of a patient with a novel homozygous mutation in the TRPM6 gene.
Tosun et al., In J Clin Res Pediatr Endocrinol, Jan 2016
UNASSIGNED: Hereditary hypomagnesemia with secondary hypocalcemia (HSH) is a rare autosomal recessive disease caused by mutations in the Transient Receptor Potential Melastatin 6 (TRPM6) gene.
Mesendogen, a novel inhibitor of TRPM6, promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells through alteration of magnesium homeostasis.
Feng et al., Urbana, United States. In Heliyon, Jan 2016
UNASSIGNED: The homo- and hetero-tetrameric channel complexes formed by transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) (collectively referred to as TRPM6/TRPM7 channels in this study) are the major regulators of cellular magnesium uptake, yet the exact roles of TRPM6/TRPM7 channels and cellular magnesium homeostasis during development are poorly understood.
The role of calbindin-D28k on renal calcium and magnesium handling during treatment with loop or thiazide diuretics.
Lien et al., Dschang, Cameroon. In Am J Physiol Renal Physiol, Dec 2015
Urine Mg excretion was increased and TRPM6 was upregulated by both CTZ and FSM in WT and KO mice.
Pathophysiology of Calcium, Phosphorus, and Magnesium Dysregulation in Chronic Kidney Disease.
Rodriguez et al., Córdoba, Spain. In Semin Dial, Nov 2015
Modification of the TRPM6 channel in the distal tubule may also have a role.
TRPM7 and its role in neurodegenerative diseases.
Singh et al., Grand Forks, United States. In Channels (austin), Oct 2015
Among the known 8 TRPM channels only TRPM6 and TRPM7 channels are highly permeable to both Ca(2+) and Mg(2+); however here we will only focus on TRPM7 as unlike TRPM6, TRPM7 channels are abundantly expressed in neuronal cells.
The art of magnesium transport.
de Baaij, Nijmegen, Netherlands. In Magnes Res, Sep 2015
TRPM6 mediates apical Mg(2+) entry into the DCT cell and is highly regulated by EGF, insulin and pH.
Magnesium in man: implications for health and disease.
Bindels et al., Nijmegen, Netherlands. In Physiol Rev, 2015
Over the last decade, several hereditary forms of hypomagnesemia have been deciphered, including mutations in transient receptor potential melastatin type 6 (TRPM6), claudin 16, and cyclin M2 (CNNM2).
Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin.
Maier et al., Roma, Italy. In Sci Rep, 2014
Accordingly, resistant cells express lower amounts of the TRPM6 and 7, both involved in magnesium transport.
Dietary Inulin Fibers Prevent Proton-Pump Inhibitor (PPI)-Induced Hypocalcemia in Mice.
Bindels et al., Nijmegen, Netherlands. In Plos One, 2014
Additionally, intestinal and renal mRNA levels of the Trpm6 gene were reduced after inulin intake.
Mg, Zn and Cu Transport Proteins: A Brief Overview from Physiological and Molecular Perspectives.
Kambe et al., Kyoto, Japan. In J Nutr Sci Vitaminol (tokyo), 2014
Specifically, TRPM6 channels in Mg absorption, ZIP4 and ZnT1 transporters for Zn absorption, and CTR1 and ATP7A for Cu absorption are overviewed.
TRPM channels and magnesium in early embryonic development.
Runnels et al., United States. In Int J Dev Biol, 2014
Mutations in TRPM6, including amino acid substitutions that prevent its heterooligomerization with TRPM7, occur in the rare autosomal-recessive disease hypomagnesemia with secondary hypocalcemia (HSH).
Analysis of Factors Influencing the Development of Hypomagnesemia in Patients Receiving Cetuximab Therapy for Head and Neck Cancer.
Nagayama et al., Ōsaka, Japan. In Yakugaku Zasshi, 2014
Magnesium is reabsorbed by transient receptor potential subfamily melastatin 6 (TRPM6) in the distal convoluted tubule.
Novel Alleles of gon-2, a C. elegans Ortholog of Mammalian TRPM6 and TRPM7, Obtained by Genetic Reversion Screens.
Yuen et al., München, Germany. In Plos One, 2014
The C. elegans genes, gon-2, gtl-1 and gtl-2, encode paralogous TRP cation channel proteins that are similar in sequence and function to human TRPM6 and TRPM7.
Magnesium and its transporters in cancer: a novel paradigm in tumour development.
Trapani et al., Roma, Italy. In Clin Sci (lond), 2012
Alteration in the expression and/or activity of magnesium channels is a frequent finding in cancer cells.
Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy.
Hoenderop et al., Nijmegen, Netherlands. In Proc Natl Acad Sci U S A, 2012
Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy
Clinical and molecular characterization of Turkish patients with familial hypomagnesaemia: novel mutations in TRPM6 and CLDN16 genes.
Schlingmann et al., İstanbul, Turkey. In Nephrol Dial Transplant, 2012
A novel mutation of TRPM6 gene is responsible for the development of familial hypommagnesaemia in Turkish children.
Dietary Mg2+ regulates the epithelial Mg2+ channel TRPM6 in rat mammary tissue.
Wolf et al., Roma, Italy. In Magnes Res, 2011
This work confirms and extends our previous results on TRPM6 modulation by Mg(2+) availability in mammary tissues.
Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia.
Touyz et al., Ottawa, Canada. In J Hypertens, 2011
in a model of inherited hypomagnesemia, TRPM6 and TRPM7, but not paracellin-1, are downregulated
Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family.
Konrad et al., Marburg an der Lahn, Germany. In Nat Genet, 2002
Deficiency /mutations of TRPM6 causes hypomagnesemia with secondary hypocalcemia
Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia.
Sheffield et al., Iowa City, United States. In Nat Genet, 2002
Individuals with TRPM6 mutations have abnormal renal magnesium excretion. Deficiency causes hypomagnesemia with secondary hypocalcemia.
share on facebooktweetadd +1mail to friends