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Transient receptor potential cation channel, subfamily M, member 5

This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: TRPM4, melastatin, CAN, TRPM8, TRPV1
Papers using TRPM5 antibodies
Taste preference for fatty acids is mediated by GPR40 and GPR120.
Matsunami Hiroaki, In PLoS ONE, 2009
... and Trpm5-GFP transgenic mice ...
Physiological roles of TRPV2 expressed in the olfactory axon
Hirakawa Katsuhiro et al., In Acta Oto-Laryngologica, 2006
... polyclonal antibody to TRPV4 (Alomone Labs Ltd, Jerusalem, Israel) (diluted 1:200), a goat polyclonal antibody to TRPM5 (Santa Cruz Biotechnology) (diluted 1:200), a rabbit polyclonal ...
Acetylcholine increases intracellular Ca2+ in taste cells via activation of muscarinic receptors.
Koch Karl-Wilhelm, In PLoS ONE, 2001
... The original breeding pairs of TRPM5 GFP transgenic mice ...
Papers on TRPM5
Expression of calcium-activated chloride channels Ano1 and Ano2 in mouse taste cells.
Kolesnikov et al., Moscow, Russia. In Pflugers Arch, Feb 2016
Large Ca(2+)-gated currents mediated by TRPM5 were elicited in type II cells by Ca(2+) uncaging.
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.
Rorsman et al., In J Clin Invest, Jan 2016
The PKC-dependent effect of GLP-1 on membrane potential and electrical activity was mediated by activation of Na+-permeable TRPM4 and TRPM5 channels by mobilization of intracellular Ca2+ from thapsigargin-sensitive Ca2+ stores.
Association of TRPM Channel Gene Polymorphisms with Systemic Sclerosis.
Demiryurek et al., Gaziantep, Turkey. In In Vivo, Dec 2015
p<0.0001) in the TRPM3 rs1328142, and TT genotype (19.0% vs. 7.8%, p=0.0002) in TRPM5 rs34551253 (Ala456Thr) polymorphism in SSc patients when compared to controls.
A novel cholinergic epithelial cell with chemosensory traits in the murine conjunctiva.
Kummer et al., Gießen, Germany. In Int Immunopharmacol, Nov 2015
Cholinergic conjunctival epithelial cells were immunoreactive for components of the canonical taste transduction signaling cascade, i.e. α-gustducin, phospholipase Cβ2 and the monovalent cation channel TRPM5.
Cholinergic chemosensory cells of the thymic medulla express the bitter receptor Tas2r131.
Kummer et al., Gießen, Germany. In Int Immunopharmacol, Nov 2015
We recently described a distinct subset of medullary epithelial cells in the murine thymus which express the acetylcholine-synthesizing enzyme choline acetyltransferase (ChAT) and components of the canonical taste transduction cascade, i.e. transient receptor potential melastatin-like subtype 5 channel (TRPM5), phospholipase Cβ2, and Gα-gustducin.
Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways.
Wen et al., Suzhou, China. In Biochem Pharmacol, Oct 2015
We adopted inhibitors of PLC and TRPM5 known to be involved in bitter taste transduction to investigate the underlying pathways mediated in berberine-induced GLP-1 secretion.
Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception.
Bassoli et al., Milano, Italy. In Molecules, 2014
Rutamarin is an agonist of TRPM5 and TRPV1 and a strong antagonist of TRPM8 ion channels.
Ablation of TRPM5 in Mice Results in Reduced Body Weight Gain and Improved Glucose Tolerance and Protects from Excessive Consumption of Sweet Palatable Food when Fed High Caloric Diets.
Brodin et al., Mölndal, Sweden. In Plos One, 2014
The calcium activated cation channel transient receptor potential channel type M5 (TRPM5) is part of the downstream machinery of the taste receptors and have been shown to play a central role in taste signalling.
How ORAI and TRP channels interfere with each other: interaction models and examples from the immune system and the skin.
Hoth et al., Homburg, Germany. In Eur J Pharmacol, 2014
TRPM4, TRPM5) to divalent selectivity (i.e.
TRPs in taste and chemesthesis.
Roper, Miami, United States. In Handb Exp Pharmacol, 2013
Specifically, TRPM5 acts downstream of taste receptors in the taste transduction pathway.
Liman, Los Angeles, United States. In Handb Exp Pharmacol, 2013
TRPM5 is a Ca(2+)-activated cation channel that mediates signaling in taste and other chemosensory cells.
Vennekens et al., Leuven, Belgium. In Handb Exp Pharmacol, 2013
Unlike TRPM5, its closest relative in the transient receptor potential family, TRPM4 proteins are widely expressed in the body.
TRPs in olfaction.
Zufall, Homburg, Germany. In Handb Exp Pharmacol, 2013
There is mounting evidence that TRPC2 is not the only TRP channel expressed in cells of the olfactory system but that other TRP channel subtypes such as TRPC1, TRPC4, TRPC6, TRPM4, and TRPM5 could also play important functional roles in mammalian olfaction.
Second-order input to the medial amygdala from olfactory sensory neurons expressing the transduction channel TRPM5.
Finger et al., Aurora, United States. In J Comp Neurol, 2012
some amygdalopetal mitral cells extended dendrites to non-TRPM5-GFP glomeruli and vice versa, suggesting that, although significant overlapping glomerular innervation is observed between these two features, it is not absolute
A conditioned aversion study of sucrose and SC45647 taste in TRPM5 knockout mice.
Delay et al., Burlington, United States. In Chem Senses, 2012
There may be a TRPM5-independent transduction pathway for detecting the taste of sweetening substances.
TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1.
Gilbertson et al., Logan, United States. In Am J Physiol Cell Physiol, 2012
The prototypical long-chain free fatty acid stimulus, linoleic acid, depolarizes tumor cells in vitro via activation of TRPM5.
Transient receptor potential channel m4 and m5 in magnocellular cells in rat supraoptic and paraventricular nuclei.
Armstrong et al., United States. In J Neuroendocrinol, 2011
These channels may play an important role in determining the distinct firing properties of vasopressin neurones in the supraoptic nucleus.
FXYD6, a Na,K-ATPase regulator, is expressed in type II taste cells.
Kusakabe et al., Moriya, Japan. In Biosci Biotechnol Biochem, 2010
FXYD6, a Na,K-ATPase regulator, is expressed in type II taste cells. Fxyd6 is coexpressed with transient receptor potential cation channel, subfamily M, member 5 (Trpm5), a critical component of the taste signal transduction pathways.
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste.
Nilius et al., Leuven, Belgium. In Nature, 2006
TRPM5 is a highly temperature-sensitive, heat-activated channel: inward TRPM5 currents increase steeply at temperatures between 15 and 35 degrees C
Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.
Ryba et al., San Diego, United States. In Cell, 2003
Essential sensory transduction component from taste GPCRs for sweet, bitter, umami tastes
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