Rho kinase activity governs arteriolar myogenic depolarization.
Burlington, United States. In J Cereb Blood Flow Metab, Jan 2016
Because of the well-established role of TRPM4 in pressure-induced depolarization, possible modulatory effects of Rho-associated protein kinase on TRPM4 currents were explored using patch clamp electrophysiology.
Inherited progressive cardiac conduction disorders.
Bern, Switzerland. In Curr Opin Cardiol, 2015
RECENT FINDINGS: Inherited PCCD in structurally normal hearts has been found to be linked to genetic variants in the ion channel genes SCN5A, SCN1B, SCN10A, TRPM4, and KCNK17, as well as in genes coding for cardiac connexin proteins.
Glibenclamide for the treatment of ischemic and hemorrhagic stroke.
Baltimore, United States. In Int J Mol Sci, 2014
Inhibiting endothelial, neuronal, astrocytic and oligodendroglial sulfonylurea receptor 1-transient receptor potential melastatin 4 (Sur1-Trpm4) channels and, in some cases, microglial KATP (Sur1-Kir6.2) channels, with glibenclamide is protective in a variety of contexts.
Vascular TRP channels: performing under pressure and going with the flow.
Burlington, United States. In Physiology (bethesda), 2014
In this review, we explore the role of TRP channels, particularly endothelial TRPV4 and smooth muscle TRPC6 and TRPM4 channels, in vascular mechanosensing circuits, placing their putative mechanosensitivity in context with other proposed upstream and downstream signaling pathways.