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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Transient receptor potential cation channel, subfamily M, member 3

TRPM3, melastatin 2
The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: melastatin, Trp7, CAN, TRPV4, V1a
Papers on TRPM3
Data-driven Analysis of TRP Channels in Cancer: Linking Variation in Gene Expression to Clinical Significance.
Shin et al., Seoul, South Korea. In Cancer Genomics Proteomics, Feb 2016
RESULTS: TRPM2 was found overexpressed in most tumors, whereas TRPM3 was broadly down-regulated.
TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation.
Shimizu et al., Tokyo, Japan. In Free Radic Biol Med, Jan 2016
Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable channel that is activated by oxidative stress through the production of ADP-ribose.
Francisella tularensis catalase restricts immune function by impairing TRPM2 channel activity.
Melendez et al., New York City, United States. In J Biol Chem, Jan 2016
2APB but not SKF abrogated ΔkatG-dependent increases in macrophage actin remodeling and IL-6 secretion, suggesting a role for H2O2-mediated Ca2+ entry through the transient receptor potential melastatin 2 (TRPM2) channel in macrophages.
Stimulation-dependent gating of TRPM3 channel in planar lipid bilayers.
Zakharian et al., Peoria, United States. In Faseb J, Jan 2016
In somatosensory neurons, TRPM3 has been implicated in temperature perception and inflammatory hyperalgesia, whereas in pancreatic β-cells the channel has been linked to glucose-induced insulin release.
The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to β-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment.
Jackson et al., Kyoto, Japan. In J Neurosci, Dec 2015
The transient receptor potential melastatin 2 (TRPM2) channel, a Ca(2+)-permeable nonselective cation channel activated by oxidative stress, has been implicated in neurodegenerative diseases, and more recently in amyloid-induced toxicity.
The molecular and cellular basis of thermosensation in mammals.
McKemy et al., United States. In Curr Opin Neurobiol, Oct 2015
TRPV homologues and TRPA1 are also implicated, but recent genetic evidence has diminished their significance in thermosensation and suggests that a number of newly identified thermosensitive channels, including TRPM3, two-pore potassium channels, and the chloride channel Ano1, require further consideration.
Designer small molecules to target calcium signalling.
Potter et al., Bath, United Kingdom. In Biochem Soc Trans, Jun 2015
Adenosine 5'-diphosphoribose (ADPR) activates the Ca2+-, Na+- and K+-permeable transient receptor potential melastatin 2 (TRPM2) cation channel.
TRPM2 Channel-Mediated ROS-Sensitive Ca(2+) Signaling Mechanisms in Immune Cells.
Jiang et al., Xinxiang, China. In Front Immunol, 2014
Transient receptor potential melastatin 2 (TRPM2) proteins form Ca(2+)-permeable cationic channels that are potently activated by reactive oxygen species (ROS).
A dual role of transient receptor potential melastatin 2 channel in cytotoxicity induced by silica nanoparticles.
Yang et al., Hangzhou, China. In Sci Rep, 2014
Transient receptor potential melastatin 2 (TRPM2) channel is known to be a cellular redox potential sensor that provides an important pathway for increasing the [Ca(2+)]i under oxidative stress.
TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.
Czyzyk-Krzeska et al., Cincinnati, United States. In Cancer Cell, 2014
Here we establish, using shRNAs, a dominant-negative mutant, and a pharmacologic inhibitor, mefenamic acid (MFA), that the Transient Receptor Potential Melastatin 3 (TRPM3) channel promotes the growth of clear cell renal cell carcinoma (ccRCC) and stimulates MAP1LC3A (LC3A) and MAP1LC3B (LC3B) autophagy.
Targeting ions-induced autophagy in cancer.
Jäättelä et al., Roma, Italy. In Cancer Cell, 2014
In this issue of Cancer Cell, Hall and colleagues describe a TRPM3-dependent autophagy pathway that is selectively important for clear cell renal cell carcinoma and can be effectively inhibited.
Trafficking of ThermoTRP Channels.
Ferrer-Montiel et al., Alacant, Spain. In Membranes (basel), 2013
This review will focus on the recent advances trafficking of the thermoTRP channels, TRPV1, TRPV2, TRPV4, TRPM3, TRPM8 and TRPA1, into/from the plasma membrane.
Philipp et al., Marburg an der Lahn, Germany. In Handb Exp Pharmacol, 2013
Like most other members of the TRP family, the Trpm3 gene encodes proteins that form cation-permeable ion channels on the plasma membrane.
Calmodulin and S100A1 protein interact with N terminus of TRPM3 channel.
Teisinger et al., Praha, Czech Republic. In J Biol Chem, 2012
Calmodulin and S100A1 protein interact with N terminus of TRPM3 channel.
Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone.
Beech et al., Leeds, United Kingdom. In Cell Calcium, 2012
Progesterone (0.01-10muM) suppressed TRPM3 activity evoked by pregnenolone sulphate.
Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception.
Peirson et al., Oxford, United Kingdom. In Eur J Neurosci, 2012
data support an indirect role for TRPM3 in pupillary light responses
Pregnenolone sulfate activates basic region leucine zipper transcription factors in insulinoma cells: role of voltage-gated Ca2+ channels and transient receptor potential melastatin 3 channels.
Thiel et al., Homburg, Germany. In Mol Pharmacol, 2011
Expression of TRPM3 or depolarization of insulinoma cells is required to connect pregnenolone sulfate stimulation with enhanced gene transcription.
Activation of steroid-sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats.
Valenzuela et al., Albuquerque, United States. In J Neurochem, 2011
TRPM3 channels are novel modulators of glutamatergic transmission in the neonatal cerebellar cortex.
A TRP channel-steroid marriage.
Voets et al., Leuven, Belgium. In Nat Cell Biol, 2008
A surprising functional association between TRPM3, a mysterious member of the family of transient receptor potential (TRP) cation channels, and the sulphated version of pregnenolone, 'mother' of all steroid hormones, has been identified.
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells.
Oberwinkler et al., Homburg, Germany. In Nat Cell Biol, 2008
TRPM3 is an essential component of an ionotropic steroid receptor enabling unanticipated crosstalk between steroidal and insulin-signalling endocrine systems.
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