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Transient receptor potential cation channel, subfamily C, member 4

TRPC4, Trp4
This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: TRPC1, TRPC3, TRPC5, Trp6, CAN
Papers on TRPC4
Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels.
Zhu et al., Homburg, Germany. In Proc Natl Acad Sci U S A, Feb 2016
Although TRPC3/C6/C7 can be directly activated by diacylglycerols produced by PLC breakdown of phosphatidylinositol 4,5-bisphosphate (PIP2), the mechanism by which the PLC pathway activates TRPC4/C5 remains unclear.
Data-driven Analysis of TRP Channels in Cancer: Linking Variation in Gene Expression to Clinical Significance.
Shin et al., Seoul, South Korea. In Cancer Genomics Proteomics, Feb 2016
TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer.
Intracellular postsynaptic cannabinoid receptors link thyrotropin-releasing hormone receptors to TRPC-like channels in thalamic paraventricular nucleus neurons.
Renaud et al., Ottawa, Canada. In Neuroscience, Jan 2016
Collectively, the data imply that activation of TRH receptors in these midline thalamic neurons engages novel signaling pathways that include postsynaptic intracellular CB1 and CB2 receptors in the activation of TRPC4/5-like channels.
Intracellular spermine blocks TRPC4 channel via electrostatic interaction with C-terminal negative amino acids.
So et al., Seoul, South Korea. In Pflugers Arch, Jan 2016
TRPC4 channels are known to be involved in neurogenic contraction of ileal smooth muscle cells via generating cationic current after muscarinic stimulation (muscarinic cationic current (mIcat)).
Natural and synthetic flavonoid modulation of TRPC5 channels.
Bon et al., Leeds, United Kingdom. In Br J Pharmacol, Dec 2015
It inhibited TRPC4 channels similarly but its inhibitory effect on TRPC1-TRPC5 heteromeric channels was weaker.
Role of the ER stress in prostaglandin E2/E-prostanoid 2 receptor involved TGF-β1-induced mice mesangial cell injury.
Yin et al., Nantong, China. In Mol Cell Biochem, Nov 2015
EP2 deficiency in these MCs augmented the coupling of TGF-β1 to ER stress-associated proteins [chaperone glucose-regulated protein 78 (GRP78), transient receptor potential channel 1 (TRPC1), and transient receptor potential channel 4 (TRPC4)], and upregulation of EP2 showed no significant change of GRP78, but augmented the expression of TRPC1, while TRPC4 expression was downregulated in comparison to normal MCs.
[Bone and Calcium Research Update 2015. Intracellular Ca2+ regulation in endothelial cells].
Isshiki, Tokyo, Japan. In Clin Calcium, 2015
Such store-operated Ca2+ entry comprises organization of a Ca2+ signal complex at the local subplasmalemmal domain involving TRPC4, caveolin1, and STIM1, a Ca2+ sensor protein for intracellular Ca2+ stores.
Canonical transient receptor potential 4 and its small molecule modulators.
Zhu et al., Hefei, China. In Sci China Life Sci, 2015
Canonical transient receptor potential 4 (TRPC4) forms non-selective cation channels that contribute to phospholipase C-dependent Ca(2+) entry into cells following stimulation of G protein coupled receptors and receptor tyrosine kinases.
The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels.
So et al., Seoul, South Korea. In Channels (austin), 2014
TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons.
Kisspeptin and Gonadotropin-Releasing Hormone Neuronal Excitability: Molecular Mechanisms Driven by 17β-Estradiol.
Kelly et al., Portland, United States. In Neuroendocrinology, 2014
These include not only TRPC4 channels but also low-voltage-activated T-type calcium channels and high-voltage-activated L-, N- and R-type calcium channel transcripts.
Psychiatric Disorders and TRP Channels: Focus on Psychotropic Drugs.
Demirdaş et al., Isparta, Turkey. In Curr Neuropharmacol, 2014
Activation of TRPC4, TRPC5, and TRPV1 cation channels in the etiology of psychiatric disorders such as anxiety, fear-associated responses, and depression modulate calcium ion influx.
Orai1 determines calcium selectivity of an endogenous TRPC heterotetramer channel.
Stevens et al., Mobile, United States. In Circ Res, 2012
Orai1 interacts with TRPC4 in the endogenous channel complex, where it controls TRPC1/4 activation and channel permeation characteristics, including calcium selectivity, important for control of endothelial cell barrier function.
Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels.
So et al., Seoul, South Korea. In J Biol Chem, 2012
an essential role of Galpha(i) proteins as novel activators for TRPC4/5 and reveal the molecular mechanism by which G-proteins activate the channels.
NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells.
Egger et al., Homburg, Germany. In J Neurosci, 2012
This study concluded that TRPC4 can be activated downstream of NMDA receptor activation and contribute to slow synaptic transmission in the olfactory bulb, including the calcium dynamics required for asynchronous release from the granule cell spine.
The Ca(2+) sensor stromal interaction molecule 1 (STIM1) is necessary and sufficient for the store-operated Ca(2+) entry function of transient receptor potential canonical (TRPC) 1 and 4 channels in endothelial cells.
Tiruppathi et al., Chicago, United States. In Mol Pharmacol, 2012
TRPC1 and TRPC4 can interact with STIM1 to form functional store-operated Ca(2+)-entry channels, which are essential for mediating Ca(2+) entry-dependent disruption of the endothelial barrier
Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration.
Zheng et al., Little Rock, United States. In Mol Pharmacol, 2012
report that the large depolarizing plateau potential that underlies the epileptiform burst firing induced by metabotropic glutamate receptor agonists in lateral septal neurons was completely abolished in TRPC1/4 double-knockout mice
Essential role for TRPC5 in amygdala function and fear-related behavior.
Clapham et al., Boston, United States. In Cell, 2009
The transient receptor potential channel 5 (TRPC5) is predominantly expressed in the brain where it can form heterotetrameric complexes with TRPC1 and TRPC4 channel subunits.
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels.
Muallem et al., Dallas, United States. In Nat Cell Biol, 2007
Here, we report that STIM1 binds TRPC1, TRPC4 and TRPC5 and determines their function as SOCs.
Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice.
Nilius et al., Homburg, Germany. In Nat Cell Biol, 2001
Here we describe a store-operated Ca2+ current in vascular endothelium and show that endothelial cells of mice deficient in TRP4 (also known as CCE1) lack this current.
L-asparaginase-deficient mutants of yeast.
Mortimer et al., In Science, 1970
The L-asparaginase gene (aspl) is located about 18 centimorgans from a gene governing tryptophan synthesis (trp4) on fragment 2 of the map.
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