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TRM82 Trm82p

Trm82, WDR4, Trm82p
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Trm8, CAN, U2AF35, GST, Ubiquitin
Papers on Trm82
Mutation in WDR4 impairs tRNA m(7)G46 methylation and causes a distinct form of microcephalic primordial dwarfism.
Alkuraya et al., Riyadh, Saudi Arabia. In Genome Biol, 2014
WDR4 is the human ortholog of the yeast Trm82, an essential component of the Trm8/Trm82 holoenzyme that effects a highly conserved and specific (m(7)G46) methylation of tRNA.
A novel cause for primordial dwarfism revealed: defective tRNA modification.
Ribas de Pouplana et al., Barcelona, Spain. In Genome Biol, 2014
A mutation in the WDR4 gene, coding for a tRNA-modifying enzyme, leads to reduced levels of guanosine methylation in tRNA in patients with primordial dwarfism.
Cognition and hippocampal plasticity in the mouse is altered by monosomy of a genomic region implicated in Down syndrome.
Herault et al., Barcelona, Spain. In Genetics, 2014
Whole-genome expression studies carried out on hippocampus showed that the transcription of only a small number of genes is affected, mainly from the genetic interval (Cbs, Rsph1, Wdr4), with a few additional ones, including the postsynaptic Gabrr2, Gabbr1, Grid2p, Park2, and Dlg1 and the components of the Ubiquitin-mediated proteolysis (Anapc1, Rnf7, Huwe1, Park2).
A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome.
Herault et al., Orléans, France. In Hum Mol Genet, 2010
Expression analysis pinpoints several genes, such as Ndufv3, Wdr4, Pknox1 and Cbs, as candidates whose overexpression in the hippocampus might facilitate learning and memory in Ts1Yah mice.
Rapid tRNA decay can result from lack of nonessential modifications.
Phizicky et al., Rochester, United States. In Mol Cell, 2006
We show here that m7G46 methyltransferase Trm8p/Trm82p acts as a hub of synthetic interactions with several tRNA modification enzymes, resulting in temperature-sensitive growth.
tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p.
Phizicky et al., Rochester, United States. In Rna, 2005
a second role of Trm82p is to stabilize Trm8p in an active conformation
Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.
Phizicky et al., Rochester, United States. In Rna, 2002
ORF YDR165w encodes Trm82, a less highly conserved protein containing putative WD40 repeats, which are often implicated in macromolecular interactions.
Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein.
Scott et al., Genève, Switzerland. In Genomics, 2000
We isolated a full-length cDNA (WDR4) encoding a novel WD-repeat protein and its mouse homologue.
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