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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Neurotrophic tyrosine kinase, receptor, type 1

trkA, Trk
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NGF, TrkB, Brain-derived neurotrophic factor, p75, CAN
Papers using trkA antibodies
The suppressive effect of an intra-prefrontal cortical infusion of BDNF on cocaine-seeking is Trk receptor and extracellular signal-regulated protein kinase mitogen-activated protein kinase dependent
Sun Wei-Lun et al., In Frontiers in Systems Neuroscience, 2010
... infused bilaterally with 1 μl of 35.7 mM K252a (a non-selective kinase inhibitor with high affinity for Trk receptors-Biomol) or 50% DMSO vehicle ...
The adenosine A2A receptor agonist, CGS-21680, blocks excessive rearing, acquisition of wheel running, and increases nucleus accumbens CREB phosphorylation in chronically food-restricted rats
Furukawa Shoei et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... The MEK inhibitor PD98059 came from Wako, and the Trk inhibitor K252a, from Santa Cruz Biotechnology (Santa Cruz, CA) ...
N-Cadherin is expressed by putative stem/progenitor cells and melanocytes in the human limbal epithelial stem cell niche.
Li De-Quan et al., In Molecular Vision, 2006
... monoclonal antibody (mAb) against CNTF receptor, CNTFRα (AN-B2), all corresponding blocking peptides for NGF, BDNF, TrkA, and GFRα-1 specific antibodies, were purchased from Santa Cruz Biotechnology ...
Molecular beacons
Kojima Masami et al., In Molecular Brain, 2003
... Santa Cruz Biotechnology (Santa Cruz, CA); the anti-GFP antibody was from MBL (Nagoya, Japan); the anti-phospho-Trk (Y490) was from Cell Signaling (Beverly, MA); anti-MAP2 (microtubule-associated ...
SISA online statistical analysis, Simple Interactive Statistical Analysis
Wordinger Robert J et al., In BMC Neuroscience, 2003
... Polyclonal antibodies to Trk A, Trk B, Trk C, truncated Trk B (Trk B.T) and phosphorylated Trk were purchased from Santa Cruz Biotechnology Inc, Santa Cruz, CA ...
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Papers on trkA
The expression of β3 -adrenoceptors and their function in the human prostate.
Ozono et al., Hamamatsu, Japan. In Prostate, Feb 2016
Strips of human normal prostate or BPH were suspended in organ baths and exposed to isoproterenol, dobutamine, procaterol, and TRK-380 to investigate their relaxant effects on KCl-induced contractions, and their inhibitory effects on electrical field stimulation (EFS)-induced contractions.
PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth.
Im et al., Chicago, United States. In Ann Rheum Dis, Feb 2016
In PKCδ null mice, increases in sensory neuron distribution in knee OA synovium and activation of the NGF-tropomyosin receptor kinase (TrkA) axis in innervating dorsal root ganglia were highly correlated with knee OA hyperalgesia.
Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats.
Xian et al., Adelaide, Australia. In J Bone Miner Res, Feb 2016
After a drill-hole injury was made in the tibial growth plate and bone, increased injury site mRNA expression was observed for neurotrophins NGF, BDNF, NT-3 and NT-4 and their Trk receptors.
Dissecting the Molecular Mechanism of Nucleotide-Dependent Activation of the KtrAB K+ Transporter.
Morais-Cabral et al., Porto, Portugal. In Plos Biol, Jan 2016
KtrAB belongs to the Trk/Ktr/HKT superfamily of monovalent cation (K+ and Na+) transport proteins that closely resemble K+ channels.
Chronic mild stress influences nerve growth factor through a matrix metalloproteinase-dependent mechanism.
Budziszewska et al., Kraków, Poland. In Psychoneuroendocrinology, Jan 2016
Additionally, the decreased level of m-NGF together with the increased level of pro-NGF can decrease TrkA-mediated neuronal survival signalling and enhance the action of pro-NGF on the p75(NTR) receptor, respectively, to evoke pro-apoptotic signalling.
Modulation of neurotrophic signaling pathways by polyphenols.
Firuzi et al., Shīrāz, Iran. In Drug Des Devel Ther, Dec 2015
Assessment of underlying mechanisms, especially in PC12 neuronal-like cells, reveals that direct agonistic effect on tropomyosin receptor kinase (Trk) receptors, the main receptors of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) explains the action of few polyphenols such as 7,8-dihydroxyflavone.
Entrectinib: a potent new TRK, ROS1, and ALK inhibitor.
Raez et al., Edegem, Belgium. In Expert Opin Investig Drugs, Nov 2015
AREAS COVERED: This review outlines the pharmacokinetics, pharmacodynamics, mechanism of action, safety, tolerability, pre-clinical studies and clinical trials of entrectinib, a promising novel agent for the treatment of advanced solid tumors with molecular alterations of Trk-A, B and C, ROS1 or ALK.
NGF/TrkA Signaling as a Therapeutic Target for Pain.
Murata et al., Japan. In Pain Pract, Sep 2015
It is now known that NGF is also associated with Alzheimer's disease and intractable pain, and hence, it, along with its high-affinity receptor, tropomyosin receptor kinase (Trk) A, is considered to be 1 of the new targets for therapies being developed to treat these diseases.
Membrane-Binding Mechanism of Clostridium perfringens Alpha-Toxin.
Nagahama et al., Niigata, Japan. In Toxins (basel), 2014
The toxin binds to lipid rafts in the presence of a GM1a/TrkA complex, and metabolites from phosphatidylcholine to diacylglycerol through the enzymatic activity of alpha-toxin itself.
Neurologic Regulation and Orthodontic Tooth Movement.
Faber et al., In Front Oral Biol, 2014
The periodontium is a highly innervated structure that also provides the necessary trophic factors, such as nerve growth factor, which promote neuronal survival, maintenance and axonal growth, via interaction with specific nerve surface receptors, such as TrkA.
Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus.
Floto et al., Bethesda, United States. In Science, 2014
Deleterious mutations of either human NGFβ or its high-affinity receptor tropomyosin-related kinase receptor A (TRKA) were associated with severe S. aureus infections.
Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.
Doebele et al., Aurora, United States. In Nat Med, 2013
We identified new gene fusions in patients with lung cancer harboring the kinase domain of the NTRK1 gene that encodes the high-affinity nerve growth factor receptor (TRKA protein).
Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.
Massa et al., Stanford, United States. In Nat Rev Drug Discov, 2013
One strategy to overcome these limitations is to target individual neurotrophin receptors — such as tropomyosin receptor kinase A (TRKA), TRKB, TRKC, the p75 neurotrophin receptor or sortilin — with small-molecule ligands.
Gating of the TrkH ion channel by its associated RCK protein TrkA.
Zhou et al., New York City, United States. In Nature, 2013
TrkH assembles with TrkA, a cytosolic protein comprising two RCK (regulate the conductance of K(+)) domains, which are found in certain K(+) channels and control their gating.
The structure of the KtrAB potassium transporter.
Morais-Cabral et al., Porto, Portugal. In Nature, 2013
In bacteria, archaea, fungi and plants the Trk, Ktr and HKT ion transporters are key components of osmotic regulation, pH homeostasis and resistance to drought and high salinity.
STK25 protein mediates TrkA and CCM2 protein-dependent death in pediatric tumor cells of neural origin.
Fainzilber et al., Israel. In J Biol Chem, 2012
Down-modulation of STK25, but not STK24, rescued medulloblastoma cells from NGF-induced TrkA-dependent cell death, suggesting that STK25 is part of the death-signaling pathway initiated by TrkA and CCM2.
Kinomic profiling approach identifies Trk as a novel radiation modulator.
Willey et al., Birmingham, United States. In Radiother Oncol, 2012
TrkA inhibition resulted in radioprotection that correlated with enhanced repair of radiation-induced damage while TrkA stimulation by gambogic amide produced radiation sensitization
Relationship of a variant in the NTRK1 gene to white matter microstructure in young adults.
Thompson et al., Los Angeles, United States. In J Neurosci, 2012
This study demonistrated that NTRK1-T is important for developing white matter microstructure.
TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry.
Parada et al., Dallas, United States. In J Neurosci, 2012
This study demonistrated that demonstrated that TrkA loss results in cholinergic BF dysfunction and cognitive decline.
NGF causes TrkA to specifically attract microtubules to lipid rafts.
Grimes et al., Palmerston North, New Zealand. In Plos One, 2011
The data indicated that TrkA and p75NTR partition into membrane rafts by different mechanisms, and that the fraction of TrkA that associates with detergent resistant membranes is internalized but does not directly form signaling endosomes.
More papers using trkA antibodies
Low-affinity nerve growth factor receptor p75NTR immunoreactivity in the myocardium with sympathetic hyperinnervation
Twigg Stephen M. et al., In Journal of Cell Communication and Signaling, 2003
... A chemical inhibitor of TrkA activity, k252a, purchased from Merck-Calbiochem, Melbourne, Australia was prepared ...
The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42
Birchmeier Walter et al., In The Journal of Cell Biology, 2002
... anti-phospho-ERK1/2 (from Sigma-Aldrich); anti-HA tag (Roche); anti-NeuN antibody (Chemicon International); anti-Myc (A14), anti-SHP2 (C18), and anti-Trk (C14) antibodies from Santa Cruz Biotechnology, Inc.; Fast-Track anti-NOMA-GAP antibody ...
A population of PC12 cells that is initiating apoptosis can be rescued by nerve growth factor.
Faivre-Sarrailh Catherine, In PLoS ONE, 2000
... Anti-flotillin was purchased from Transduction Laboratories (Lexington, KY), sc11 anti-TrkA from Santa Cruz Biotechnology (Santa Cruz, CA), and ...
Sunday Driver links axonal transport to damage signaling
Goldstein Lawrence S.B. et al., In The Journal of Cell Biology, 1998
... and anti-p50 (BD Biosciences), anti-JNK1 and anti-JNK2 (BD Biosciences), anti-JNK3 (Upstate Biotechnology), anti–P-JNK and anti–P-TrkA (Cell Signaling), anti-S100 and antitubulin DM1A ...
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