gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Thyroid hormone receptor interactor 6

TRIP6, ZRP-1, OIP-1, thyroid receptor-interacting protein 6
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Zyxin, LIM, ACID, Actin, LPP
Papers on TRIP6
Gene Expression Profiling of Desmoid Tumors by cDNA Microarrays and Correlation with Progression-Free Survival.
Chibon et al., Marseille, France. In Clin Cancer Res, Oct 2015
Finally, the top two genes downregulated in no-recurrence were FECH and STOML2 and the top gene upregulated in no-recurrence was TRIP6.
Overexpression of TRIP6 promotes tumor proliferation and reverses cell adhesion-mediated drug resistance (CAM-DR) via regulating nuclear p27(Kip1) expression in non-Hodgkin's lymphoma.
He et al., Nantong, China. In Tumour Biol, Sep 2015
UNASSIGNED: Recent studies have identified that thyroid hormone receptor-interacting protein 6 (TRIP6) is implicated in tumorigenesis.
Differentially expressed proteins in human MCF-7 breast cancer cells sensitive and resistant to paclitaxel.
Kovář et al., Praha, Czech Republic. In Exp Cell Res, May 2015
With these techniques, we found three proteins expressed differently in resistant MCF-7 cells, i.e., thyroid hormone-interacting protein 6 (TRIP6; upregulated to 650%), heat shock protein 27 (HSP27; downregulated to 50%) and cathepsin D (downregulated to 28%).
TRIP6 regulates neural stem cell maintenance in the postnatal mammalian subventricular zone.
Wang et al., Taipei, Taiwan. In Dev Dyn, 2014
Thyroid hormone receptor interacting protein 6 (TRIP6) belongs to zyxin family of LIM proteins, which have been shown to interact with various proteins to mediate cellular functions.
Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-κB-dependent gene expression.
Kracht et al., Gießen, Germany. In Mol Cell, 2014
CDK6 recruitment to distinct chromatin regions of inflammatory genes was essential for proper loading of p65 to its cognate binding sites and for the function of p65 coactivators, such as TRIP6.
The LIM domain protein nTRIP6 recruits the mediator complex to AP-1-regulated promoters.
Kassel et al., Karlsruhe, Germany. In Plos One, 2013
An intriguing example is nTRIP6, the nuclear isoform of the focal adhesion protein TRIP6.
The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth.
Butt et al., München, Germany. In Biol Cell, 2013
Here, we explored the role of the Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) in ES.
Characterization of TRIP6-dependent nasopharyngeal cancer cell migration.
Zhou et al., Wuxi, China. In Tumour Biol, 2013
The current study sought to identify a new regulator for NPC cell motility in light of previous data showing a similar role of thyroid receptor interactor protein 6 (TRIP6) in other cancer cell types.
TRIP6 regulates p27 KIP1 to promote tumorigenesis.
Lin et al., Houston, United States. In Mol Cell Biol, 2013
TRIP6 is an adaptor protein that regulates cell motility and antiapoptotic signaling.
ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degeneration.
Gieseler et al., Villeurbanne, France. In Mol Biol Cell, 2013
We show that the nematode Caenorhabditis elegans has a unique zyxin-like protein, ZYX-1, which is the orthologue of the vertebrate zyxin subfamily composed of zyxin, migfilin, TRIP6, and LPP.
Gene expression profile of aquaporin 1 and associated interactors in malignant pleural mesothelioma.
Zarogiannis et al., Hyderābād, India. In Gene, 2013
Here we report that AQP1 is overexpressed in epithelioid mesothelioma and identify TRIP6 and EFEMP2 as candidate genes for further investigation in mesothelioma.
LIM Protein Ajuba Participates in the Repression of the ATR-Mediated DNA Damage Response.
Loayza et al., New York City, United States. In Front Genet, 2012
Our previous work has implicated members of the Zyxin family of LIM proteins, namely TRIP6 and LPP, in the repression of the DNA damage response (DDR) at telomeres.
Defining the role of TRIP6 in cell physiology and cancer.
Grunewald et al., Würzburg, Germany. In Biol Cell, 2012
TRIP6 is engaged in cell proliferation, differentiation, transcription regulation and contributes to genome stability. [Review]
TRIP6: an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity.
Lin et al., Birmingham, United States. In Cell Signal, 2011
TRIP6 is an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity. (Review)
The adaptor protein TRIP6 antagonizes Fas-induced apoptosis but promotes its effect on cell migration.
Lin et al., Birmingham, United States. In Mol Cell Biol, 2010
TRIP6 promotes Fas-mediated cell migration in apoptosis-resistant glioma cells. This effect is regulated via the Src-dependent phosphorylation of TRIP6 at Tyr-55.
Osteoclast inhibitory peptide-1 binding to the Fc gammaRIIB inhibits osteoclast differentiation.
Reddy et al., Charleston, United States. In Endocrinology, 2010
Data show that OIP-1 (Trip6) is an important physiologic regulator of osteoclast development and may have therapeutic utility for bone diseases with high bone turnover.
c-Src-mediated phosphorylation of thyroid hormone receptor-interacting protein 6 (TRIP6) promotes osteoclast sealing zone formation.
Lee et al., Columbus, United States. In J Biol Chem, 2010
TRIP6 is a critical downstream regulator of c-Src signaling and its phosphorylation is permissive for its presence in the sealing zone where it plays a positive role in osteoclast bone resorptive capacity
Regulatory mechanisms operative in osteoclasts.
Reddy, Charleston, United States. In Crit Rev Eukaryot Gene Expr, 2003
The osteoclast is an autocrine/paracrine, intracrine regulatory cell that produces factors such as IL-6, Annexin II, TGF-beta, OIP-1/hSca, which influence its own formation and activity.
share on facebooktweetadd +1mail to friends