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Triosephosphate isomerase 1

Triose-Phosphate Isomerase, TPI
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, fibrillin-1, HAD, Barrel
Papers using Triose-Phosphate Isomerase antibodies
KEGG: Kyoto Encyclopedia of Genes and Genomes.
Plaistow Stewart, In PLoS ONE, 1998
... RNAi and antisense constructs to silence nicotine (N) production, N production together with trypsin protease inhibitor (TPI) and jasmonate (JA) biosynthesis.
Papers on Triose-Phosphate Isomerase
Human mass balance study of TAS-102 using (14)C analyzed by accelerator mass spectrometry.
Beumer et al., Pittsburgh, United States. In Cancer Chemother Pharmacol, Feb 2016
BACKGROUND: TAS-102 is an oral fluoropyrimidine prodrug composed of trifluridine (FTD) and tipiracil hydrochloride (TPI) in a 1:0.5 ratio.
Connecting active site loop conformations and catalysis in triosephosphate isomerase: insights from a rare variation at residue 96 in the plasmodial enzyme.
Balaram et al., Bengaluru, India. In Chembiochem, Feb 2016
UNASSIGNED: Despite extensive research on triosephosphate isomerase (TIM), there exists a gap in understanding the remarkable conjunction between catalytic loop-6 (residue 166-176) movement and conformational flip of Glu165 (catalytic base) upon substrate binding, thus priming the active site for efficient catalysis.
Characterisation of two conopressin precursor isoforms in the land snail, Theba pisana.
Cummins et al., Gold Coast, Australia. In Peptides, Feb 2016
Our transcriptomic analysis of T. pisana CNS sheath tissue has revealed two conopressin gene transcripts (Tpi-conopressin-1 and Tpi-conopressin-2), each encoding for precursors containing an identical conopressin nonapeptide and a variable neurophysin.
The TIM Barrel Architecture Facilitated the Early Evolution of Protein-Mediated Metabolism.
Landweber et al., United States. In J Mol Evol, Jan 2016
The triosephosphate isomerase (TIM) barrel protein fold is a structurally repetitive architecture that is present in approximately 10 % of all enzymes.
TAS-102 an Emerging Oral Fluoropyrimidine.
Saif et al., Australia. In Anticancer Res, Jan 2016
TAS-102 is a newly-developed anti-folate drug containing the 5-FU analogue trifluridine (TFD) and tipiracil hydrochloride (TPI).
A novel antimetabolite: TAS-102 for metastatic colorectal cancer.
Baba et al., Kumamoto, Japan. In Expert Rev Clin Pharmacol, Jan 2016
UNASSIGNED: TAS-102 is a new oral anti-tumor drug, composed of a thymidine-based nucleoside analog (trifluridine: FTD) and a thymidine phosphorylase inhibitor (tipiracil hydrochloride: TPI).
Therapeutic potential of TAS-102 in the treatment of gastrointestinal malignancies.
Peters, Amsterdam, Netherlands. In Ther Adv Med Oncol, Nov 2015
TAS-102, a combination of trifluorothymidine and the thymidine phosphorylase inhibitor TPI in a 1:0.5 ratio, is a novel oral formulation, which is active in 5FU-resistant models, both in vitro and in xenograft models.
TAS-102, a novel antitumor agent: A review of the mechanism of action.
Loupakis et al., Los Angeles, United States. In Cancer Treat Rev, Nov 2015
TAS-102 is an oral combination therapy consisting of trifluridine (FTD), a thymidine-based nucleoside analog, plus tipiracil hydrochloride (TPI), a novel thymidine phosphorylase inhibitor that improves the bioavailability of FTD.
Krasavchenko et al., In Med Parazitol (mosk), Jul 2015
Genotyping was Carried out using the specific primers TPIA and TPIB to the gene encoding for the enzyme triosephosphate isomerase from the parasite.
Enzyme dynamics from NMR spectroscopy.
Palmer, New York City, United States. In Acc Chem Res, Mar 2015
This Account reviews NMR spin relaxation studies of the enzymes ribonuclease HI from mesophilic (Escherichia coli) and thermophilic (Thermus thermophilus) bacteria, E. coli AlkB, and Saccharomyces cerevisiae triosephosphate isomerase to illustrate the contributions of conformational flexibility and dynamics to diverse steps in enzyme mechanism.
A Practical Quantum Mechanics Molecular Mechanics Method for the Dynamical Study of Reactions in Biomolecules.
Mendieta et al., Madrid, Spain. In Adv Protein Chem Struct Biol, 2014
The potential of this approach is shown by the analysis of a reaction catalyzed by the enzyme triose-phosphate isomerase (TIM).
Precision is essential for efficient catalysis in an evolved Kemp eliminase.
Hilvert et al., Zürich, Switzerland. In Nature, 2013
Starting from a computationally designed catalyst for the Kemp elimination--a well-studied model system for proton transfer from carbon--we show that an artificial enzyme can be evolved that accelerates an elementary chemical reaction 6 × 10(8)-fold, approaching the exceptional efficiency of highly optimized natural enzymes such as triosephosphate isomerase.
Perspectives in enzymology of membrane proteins by solid-state NMR.
Glaubitz et al., Frankfurt am Main, Germany. In Acc Chem Res, 2013
Solid-state NMR has also provided a mechanistic understanding of soluble enzymes including triosephosphate isomerase (TIM) and different metal-binding proteins, which demonstrates a promising perspective also for membrane proteins.
Cryptic peroxisomal targeting via alternative splicing and stop codon read-through in fungi.
Bölker et al., Marburg an der Lahn, Germany. In Nature, 2012
We also detected PTS1 motifs in the glycolytic enzymes triose-phosphate isomerase and fructose-bisphosphate aldolase.
Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells.
Ralser et al., Berlin, Germany. In Cell Metab, 2011
PEP acted as feedback inhibitor of the glycolytic enzyme triosephosphate isomerase (TPI).
Energy metabolism and ageing regulation: metabolically driven deamidation of triosephosphate isomerase may contribute to proteostatic dysfunction.
Hipkiss, Birmingham, United Kingdom. In Ageing Res Rev, 2011
[Review] The activity of glycolytic enzyme TPI reveals a mechanistic link between energy metabolism and age-related proteostatic dysfunction which can suppress generation of altered proteins that characterize the aged phenotype in cells and tissues.
A proteomic approach for identification and localization of the pericellular components of chondrocytes.
Moed et al., Saint Louis, United States. In Histochem Cell Biol, 2011
A proteomic approach for identification and localization of the pericellular components of chondrocytes.
Reappraisal of triosephosphate isomerase deficiency.
Ovádi et al., In Eur J Haematol, 2011
structural changes rather than abnormal catalysis may play an important role in the clinical manifestations of TPI deficiency; the postulated high aggregation ability of the unstable Glu104Asp mutant would lead to more serious symptoms
Triosephosphate isomerase deficiency: a patient with Val231Met mutation.
Ozer et al., İzmir, Turkey. In Pediatr Neurol, 2011
A patient with triosephosphate isomerase-deficiency was found to be homozygous for a Val231Met mutation.
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
Turck et al., München, Germany. In J Psychiatr Res, 2010
This protein has been found differentially expressed in thalami from patients with schizophrenia.
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