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Tripartite motif containing 45

This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: Trim, AP-1, MAPK, NET, Ubiquitin
Papers on TRIM45
The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway.
Ariga et al., Sapporo, Japan. In Oncogene, Apr 2015
Here, we show that one of the tripartite motif-containing (TRIM) family ubiquitin ligases, TRIM45, is a novel RACK1-interacting protein and downregulates MAPK signal transduction.
Concurrent gene signatures for han chinese breast cancers.
Chuang et al., Taipei, Taiwan. In Plos One, 2012
A breast cancer risk predictive model was built based on the first supervised principal component from 16 genes (RCAN3, MCOLN2, DENND2D, RWDD3, ZMYM6, CAPZA1, GPR18, WARS2, TRIM45, SCRN1, CSNK1E, HBXIP, CSDE1, MRPL20, IKZF1, and COL20A1), and distinct survival patterns were observed between the high- and low-risk groups from the combined dataset of 408 microarrays.
TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation.
Hatakeyama et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2012
These findings suggest that TRIM45 acts as a repressor for the NF-kappaB signal and regulates cell growth.
TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1.
Liu et al., Changsha, China. In Biochem Biophys Res Commun, 2004
TRIM45 may act as a new transcriptional repressor in mitogen-activated protein kinase signaling pathway
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