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Tripartite motif containing 32

TRIM32, 3F3, HT2A, LGMD2H, BBS11
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: 5-HT1A, CAN, HAD, V1a, ACID
Papers on TRIM32
5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists.
Schnellmann et al., United States. In J Pharmacol Exp Ther, Feb 2016
In contrast, the ability of these compounds to increase PGC-1α mRNA and respiration was blocked in RPTC treated with 5-HT2A receptor siRNA or the 5-HT2A receptor antagonist eplivanserin.
Behavioral and pharmacokinetic interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-N,N-dimethyltryptamine.
Halberstadt, San Diego, United States. In Pharmacol Biochem Behav, Feb 2016
We have shown previously that monoamine oxidase-A (MAO-A) inhibitors alter the locomotor profile of the hallucinogen 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in rats, and enhance its interaction with 5-HT2A receptors.
Serotonin 2A Receptor Inverse Agonist as a Treatment for Parkinson's Disease Psychosis: A Systematic Review and Meta-analysis of Serotonin 2A Receptor Negative Modulators.
Iwata et al., Japan. In J Alzheimers Dis, Feb 2016
BACKGROUND: There is uncertainty about the efficacy and tolerability of serotonin 2A (5-HT2A) receptor negative modulators for Parkinson's disease psychosis (PDP).
Brexpiprazole for the Treatment of Schizophrenia: A Review of this Novel Serotonin-Dopamine Activity Modulator.
Citrome et al., In Clin Schizophr Relat Psychoses, Dec 2015
Brexpiprazole acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A and at adrenergic alpha1B and alpha2C receptors.
Average Information Content Maximization-A New Approach for Fingerprint Hybridization and Reduction.
Warszycki et al., Kraków, Poland. In Plos One, Dec 2015
This methodology, applied to the ligands of five cognate serotonin receptors (5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6), proved that 100 bits selected from four non-hashed fingerprints reflect almost all structural information required for a successful in silico discrimination test.
5-HT2A receptors control body temperature in mice during LPS-induced inflammation via regulation of NO production.
Kulikov et al., Novosibirsk, Russia. In Pharmacol Res, Dec 2015
UNASSIGNED: G protein-coupled 5-HT2A receptors are involved in the regulation of numerous normal and pathological physiological functions.
Phencyclidine-induced disruption of oscillatory activity in prefrontal cortex: Effects of antipsychotic drugs and receptor ligands.
Celada et al., Barcelona, Spain. In Eur Neuropsychopharmacol, Dec 2015
Atypical antipsychotic reversal may additionally involve 5-HT1A-R activation (but not 5-HT2A-R blockade) since 8-OH-DPAT and BAYx3702 (but not M100907) fully countered PCP effects.
Cox et al., Louisville, United States. In Drugs Today (barc), Nov 2015
Pimavanserin (ACP-103) is a selective inverse agonist of the 5-hydroxytryptamine 2A (5-HT2A) receptor intended to treat patients with Parkinson's disease psychosis (PDP).
Treatment for Hypoactive Sexual Desire.
Pfaus, Montréal, Canada. In Cell, Nov 2015
Flibanserin acts at cortical, limbic, hypothalamic, and brainstem nuclei to inhibit serotonin release by binding to 5-HT1A autoreceptors and block postsynaptic action of serotonin at 5-HT2A receptors.
Serotonin 2a Receptor and Serotonin 1a Receptor Interact Within the Medial Prefrontal Cortex During Recognition Memory in Mice.
Weisstaub et al., Buenos Aires, Argentina. In Front Pharmacol, 2014
As human data suggest that a constitutively decrease of 5-HT2A signaling might affect episodic memory performance we decided to compare the performance of mice with disrupted 5-HT2aR signaling (htr2a (-/-)) with wild type (htr2a (+/+)) littermates in different recognition memory and working memory tasks that differed in the level of proactive interference.
Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder.
Cunningham et al., Galveston, United States. In Pharmacol Rev, 2014
However, the 5-HT2A and 5-HT2C receptors in particular have been implicated as likely candidates for mediating the influence of 5-HT in cocaine abuse as well as to traits (e.g., impulsivity) that contribute to the development of cocaine use disorder and relapse in humans.
The role of serotonin 5-HT2A receptors in memory and cognition.
Stackman et al., Hefei, China. In Front Pharmacol, 2014
Serotonin 5-HT2A receptors (5-HT2ARs) are widely distributed in the central nervous system, especially in brain region essential for learning and cognition.
Pimavanserin for patients with Parkinson's disease psychosis: a randomised, placebo-controlled phase 3 trial.
Ballard et al., Las Vegas, United States. In Lancet, 2014
We aimed to assess safety and efficacy of pimavanserin, a selective serotonin 5-HT2A inverse agonist, in this population.
Asymmetric segregation of the double-stranded RNA binding protein Staufen2 during mammalian neural stem cell divisions promotes lineage progression.
Temple et al., United States. In Cell Stem Cell, 2012
We immunoprecipitated Stau2 to examine its cargo mRNAs, and found enrichment for known asymmetric and basal cell determinants, such as Trim32, and identified candidates, including a subset involved in primary cilium function.
Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy.
Goldberg et al., Boston, United States. In J Cell Biol, 2012
During fasting, desmin phosphorylation increases and enhances Trim32-mediated degradation of the desmin cytoskeleton, which appears to facilitate the breakdown of Z-bands and thin filaments.
TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination.
Shu et al., Wuhan, China. In J Biol Chem, 2012
TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination
TRIM32 promotes retinoic acid receptor α-mediated differentiation in human promyelogenous leukemic cell line HL60.
Hatakeyama et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2012
These findings suggest that TRIM32 functions as one of the coactivators for RARalpha-mediated transcription in acute promyelogenous leukemia cells.
TRIM32 regulates skeletal muscle stem cell differentiation and is necessary for normal adult muscle regeneration.
Schwamborn et al., Münster, Germany. In Plos One, 2011
Loss of TRIM32 function induces a LGMD2H-like phenotype and strongly affects muscle regeneration in vivo.
TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription.
Hatakeyama et al., Sapporo, Japan. In J Cell Sci, 2011
promotes neural differentiation through retinoic acid receptor-mediated transcription
The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors.
Knoblich et al., Vienna, Austria. In Cell, 2009
TRIM32 overexpression induces neuronal differentiation while inhibition of TRIM32 causes both daughter cells to retain progenitor cell fate; also it binds Argonaute-1 and thereby increases the activity of specific microRNAs.
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