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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Ceramide synthase 4

trh1, LASS4, CerS4
Functions as a potassium transporter and is required for the establishment of root tip growth. (from NCBI)
Top mentioned proteins: Thyrotropin-Releasing Hormone, T1L, LAG1, ACID, LASS5
Papers on trh1
Genomic Features in Clinical Vibrio parahaemolyticus Isolates Lacking Recognized Virulence Factors and Environmental Isolates are Dissimilar.
Banerjee et al., Ottawa, Canada. In Appl Environ Microbiol, Jan 2016
The trhPAI was not present in any environmental isolates; however, in tdh-trh- clinical isolate 10-4238 the majority of the trhPAI was present including a partial trh1 gene, which resulted in reclassification of this isolate as tdh-trh+.
Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner.
Krupenko et al., Chapel Hill, United States. In Plos One, Dec 2015
Furthermore, the siRNA silencing of CerS6 robustly protected A549 lung adenocarcinoma cells from MTX toxicity, while the silencing of another ceramide synthase, CerS4, which was also responsive to folate stress in our previous study, did not interfere with the MTX effect.
SIRT3 Deacetylates Ceramide Synthases: Implications for Mitochondrial Dysfunction and Brain Injury.
Gudz et al., United States. In J Biol Chem, Dec 2015
Reciprocal immunoprecipitation experiments revealed that CerS1, CerS2 and CerS6, but not CerS4, are associated with SIRT3 in cerebral mitochondria.
New insights into the organ-specific adverse effects of fumonisin B1: comparison between lung and liver.
Oswald et al., Toulouse, France. In Arch Toxicol, Sep 2015
Our data also indicated that FB1 is more prone to bind to CerS4 and CerS2 to deplete lung and to enrich liver in d18:1/C20:0 and d18:1/C22:0 ceramides.
Integrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolide.
Zhang et al., Beijing, China. In J Ethnopharmacol, Aug 2015
Several enzymes, including kdsr, CerS2, CerS4, CerS5 and CerS6 in the liver and Cerk in the kidney were probably responsible for the TP-induced toxic effect, identifying them as possible novel therapeutic targets.
[Molecular Detection Methods for Vibrio parahaemolyticus in Seafood].
Hara-Kudo et al., In Kansenshogaku Zasshi, Jul 2015
The species-specific genes were detected in all combinations of two strains (a tdh * trh1-positive strain and a trh2-positive strain), two kinds of shellfish (oyster and bloody clams) and molecular methods with tlh-real time PCR or rpoD-LAMP assays with DNA of alkaline heat extraction at 85-145cfu/test level.
Prospect, isolation, and characterization of microorganisms for potential use in cases of oil bioremediation along the coast of Trindade Island, Brazil.
Tótola et al., Viçosa, Brazil. In J Environ Manage, Jul 2015
The isolates Rhodococcus rhodochrous TRN7 and Nocardia farcinica TRH1 were able to use all the hydrocarbons added to the culture medium (toluene, octane, xylene, naphthalene, phenanthrene, pyrene, hexadecane, anthracene, eicosane, tetracosane, triacontane, and pentacontane).
Linking the ceramide synthases (CerSs) 4 and 5 with apoptosis, endometrial and colon cancers.
Dlamini et al., Johannesburg, South Africa. In Exp Mol Pathol, Jun 2015
Although knowledge of the role that CerSs play in cancer biology is advancing, the precise roles of distinct CerSs in different cancers are not yet fully understood, especially the roles of CerS4 and CerS5 in endometrial and colon cancers.
Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling.
Krönke et al., Köln, Germany. In J Invest Dermatol, Jun 2015
Here we demonstrate that ceramide synthase 4 (CerS4) is highly expressed in the epidermis of adult mice where it is localized in the interfollicular epidermis and defined populations within the pilosebaceous unit.
Potassium transporter TRH1 subunits assemble regulating root-hair elongation autonomously from the cell fate determination pathway.
Hatzopoulos et al., Athens, Greece. In Plant Sci, Feb 2015
Trichoblasts of trh1 plants form root-hair initiation sites that fail to undergo tip growth resulting in a tiny root-hair phenotype.
Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells.
Grösch et al., Frankfurt am Main, Germany. In Biochem Pharmacol, 2015
In human breast cancer tissue, we detected a significant increase in CerS4 and CerS6 mRNA in estrogen receptor positive (ER+) cancer tissue.
Characterization of trh2 harbouring Vibrio parahaemolyticus strains isolated in Germany.
Strauch et al., Berlin, Germany. In Plos One, 2014
The complete trh sequences revealed clustering into three different types: trh1 and trh2 genes and a pseudogene Ψtrh.
Development of a colony hybridization method for the enumeration of total and potentially enteropathogenic Vibrio parahaemolyticus in shellfish.
Croci et al., Roma, Italy. In Int J Food Microbiol, 2014
Four digoxigenin-labeled probes were designed for pathogenic strains enumeration (tdh1, tdh2, trh1 and trh2 probes) and one for total V. parahaemolyticus count (toxR probe).
Familial combined hyperlipidemia: from molecular insights to tailored therapy.
Brouwers et al., Nijmegen, Netherlands. In Curr Opin Lipidol, 2014
plasma proprotein convertase subtilisin/kexin type 9 [PCSK9] and phospholipid transfer protein activity), have revealed new genes of interest, among which SLC25A40 and LASS4.
Ammonium-induced loss of root gravitropism is related to auxin distribution and TRH1 function, and is uncoupled from the inhibition of root elongation in Arabidopsis.
Shi et al., Nanjing, China. In J Exp Bot, 2012
Ammonium-induced loss of root gravitropism is related to auxin distribution and TRH1 pathway.
Brainstem neuropeptides and vagal protection of the gastric mucosal against injury: role of prostaglandins, nitric oxide and calcitonin-gene related peptide in capsaicin afferents.
Tache, Los Angeles, United States. In Curr Med Chem, 2011
Activation of endogenous TRH-TRH1 receptor signaling located in the brainstem plays a role in adaptive gastric protection against damaging agents.
Linkage and association of phospholipid transfer protein activity to LASS4.
Jarvik et al., Seattle, United States. In J Lipid Res, 2011
The linkage and association of phospholipid transfer protein activity to LASS4 were studied.
Potassium carrier TRH1 is required for auxin transport in Arabidopsis roots.
Grabov et al., Ashford, United Kingdom. In Plant J, 2004
Disruption of the TRH1 potassium transporter impairs root hair development in Arabidopsis, and also affects root gravitropic behaviour.
Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.
Futerman et al., Israel. In J Biol Chem, 2003
Lag1p family members trh1 and trh4 regulate (dihydro)ceramide synthases responsible for production of sphingolipids containing different fatty acids
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