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Telomeric repeat binding factor

TRF1, Telomeric Repeat Binding Protein 1, PIN2, hpr1
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TRF2, CAN, PIN, ACID, Thymopentin
Papers on TRF1
Effects of the ionic liquid 1-hexyl-3-methylimidazolium bromide on root gravitropism in Arabidopsis seedlings.
Li et al., Xinxiang, China. In Ecotoxicol Environ Saf, Mar 2016
The signal intensity and gene expression of auxin efflux carriers PIN2 and PIN3 were obviously decreased by IL stress.
Inversion induced Manihot esculenta stem tubers express key tuberization genes; Mec1, RZF, SuSy1 and PIN2.
Sutton et al., Trinidad and Tobago. In Plant Signal Behav, Feb 2016
RT-PCR revealed that several key genes (Mec1, RZF, SuSy1 and PIN2) involved in root tuberization were also expressed in these stem tubers.
Catalytic Borylative Opening of Propargyl Cyclopropane, Epoxide, Aziridine, and Oxetane Substrates: Ligand Controlled Synthesis of Allenyl Boronates and Alkenyl Diboronates.
Szabó et al., Stockholm, Sweden. In Angew Chem Int Ed Engl, Jan 2016
In this process propargyl derivatives of strained three/four-membered rings were employed as substrates and B2 pin2 was used as the boronate source.
E-type cyclins modulate telomere integrity in mammalian male meiosis.
Wolgemuth et al., New York City, United States. In Chromosoma, Jan 2016
Moreover, the insufficient level of these proteins correlated with an increase of γ-H2AX foci in the affected telomeres and resulted in telomere associations involving TRF1 and telomere detachment in later prophase-I stages.
Discovery of variant infectious salmon anaemia virus (ISAV) of European genotype in British Columbia, Canada.
Kibenge et al., Charlottetown, Canada. In Virol J, Dec 2015
To date, all of the ISAV isolates from the clinical disease, ISA, have had deletions in the highly polymorphic region (HPR) on ISAV segment 6 (ISAV-HPRΔ) relative to ISAV-HPR0, named numerically from ISAV-HPR1 to over ISAV-HPR30.
Cellular events of strigolactone signalling and their crosstalk with auxin in roots.
Koltai, Israel. In J Exp Bot, Aug 2015
Strigolactones are also involved with the response to phosphate conditions in roots, acting by both dampening auxin transport via depletion of PIN2 from the plasma membrane and inducing TIR1 transcription to increase auxin perception.
LPTS: A Novel Tumor Suppressor Gene and a Promising Drug Target for Cancer Intervention.
Liu et al., Chongqing, China. In Recent Pat Anticancer Drug Discov, 2014
This review successively describes the lpts genomic assembly, transcriptional regulation and structure-activity evaluation of different LPTS isoforms; then it represents the LPTS binding partners, for example Pin2/TRF1 and MCRS2, which play important roles in decreasing telomerase activity, which benefits to reveal the anticancer mechanism; subsequently, it surveys several patents of recombinant LPTS proteins such as TAT-LPTS-LC, PinX1/C-G4S-9R-G4S-mBAFF and PinX1/C-9R-mBAF that can inhibit the growth of tumor cells.
Shelterin proteins and cancer.
Trivedi et al., Vellore, India. In Asian Pac J Cancer Prev, 2014
It comprises six proteins, namely TRF1, TRF2, TIN2, POT1, TPP1 and RAP1.
The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis.
Watanabe et al., Tokyo, Japan. In Nat Cell Biol, 2014
TERB1 forms a heterocomplex with the canonical telomeric protein TRF1 and binds telomere repeat DNA.
Novel anticancer strategy aimed at targeting shelterin complexes by the induction of structural changes in telomeric DNA: hitting two birds with one stone.
Skladanowski et al., Gdańsk, Poland. In Curr Cancer Drug Targets, 2013
These changes would lead to a selective interference with the formation of telomeric DNA-shelterin complexes, especially involving TRF1 and TRF2 proteins, as these proteins bind double-stranded telomeric DNA in a sequence- and structure-dependent manner.
THOC5, a member of the mRNA export complex: a novel link between mRNA export machinery and signal transduction pathways in cell proliferation and differentiation.
Tamura et al., Hannover, Germany. In Cell Commun Signal, 2013
THO (Suppressors of the transcriptional defects of hpr1 delta by overexpression) complex 5 (THOC5) is a member of THO complex which is a subcomplex of the transcription/export complex (TREX).
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
Zhuang et al., New York City, United States. In Cell, 2013
Conditional deletion of individual components of shelterin showed that TRF2 was required for the formation and/or maintenance of t-loops, whereas deletion of TRF1, Rap1, or the POT1 proteins (POT1a and POT1b) had no effect on the frequency of t-loop occurrence.
COP1 mediates the coordination of root and shoot growth by light through modulation of PIN1- and PIN2-dependent auxin transport in Arabidopsis.
Xu et al., Lyon, France. In Development, 2012
COP1 mediates the coordination of root and shoot growth by light through modulation of PIN1- and PIN2-dependent auxin transport in Arabidopsis
Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1.
Tsai et al., Houston, United States. In J Cell Biol, 2012
The nucleostemin(NS)could promote the recruitment of PML-IV to SUMOylated TRF1 in TA(+) and ALT cells.
Lysine63-linked ubiquitylation of PIN2 auxin carrier protein governs hormonally controlled adaptation of Arabidopsis root growth.
Luschnig et al., Vienna, Austria. In Proc Natl Acad Sci U S A, 2012
PIN2 vacuolar sorting depends on modification specifically by lysine(63)-linked ubiquitin chains.
Removal of shelterin reveals the telomere end-protection problem.
de Lange et al., New York City, United States. In Science, 2012
To define the end-protection problem, we removed the whole shelterin complex from mouse telomeres through conditional deletion of TRF1 and TRF2 in nonhomologous end-joining (NHEJ) deficient cells.
PinX1 localizes to telomeres and stabilizes TRF1 at mitosis.
Counter et al., Durham, United States. In Mol Cell Biol, 2012
one function of PinX1 is to stabilize TRF1 during mitosis, perhaps to promote transition into M phase of the cell cycle.
The signal transducer NPH3 integrates the phototropin1 photosensor with PIN2-based polar auxin transport in Arabidopsis root phototropism.
Lin et al., Beijing, China. In Plant Cell, 2012
PIN2 is essential for robust root phototropism. Blue light-induced auxin flux in the root apex transition zone is dependent on PIN2, phot1, and NPH3
Telomeres avoid end detection by severing the checkpoint signal transduction pathway.
Ferreira et al., Portugal. In Nature, 2010
Here we show that fission yeast (Schizosaccharomyces pombe) cells lacking Taz1, an orthologue of human TRF1 and TRF2 (ref.
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
de Lange et al., New York City, United States. In Cell, 2009
Gene deletion experiments showed that efficient duplication of telomeres requires the shelterin component TRF1.
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