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Mediator complex subunit 13

TRAP240, Med13, spTrap240
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MED12, POLYMERASE, PCNA, CAN, V1a
Papers on TRAP240
Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.
Vahteristo et al., Helsinki, Finland. In Prostate, Jan 2016
Instead, the L1224F mutation was shown to affect interactions between MED12 and other Mediator components (MED1, MED13, MED13L, MED14, MED15, MED17, and MED24).
Regulation of cardiac miR-208a, an inducer of obesity, by rapamycin and nebivolol.
Pulakat et al., Columbia, United States. In Obesity (silver Spring), Nov 2015
In ZO rats, Rap treatment (750 μg kg(-1)  day(-1) ; 12 weeks) reduced obesity despite similar food intake, suppressed cardiac miR-208a, and increased cardiac MED13, a suppresser of obesity.
Deletion of the MED13 and CDK8 subunits of the Mediator improves the phenotype of a long-lived respiratory deficient mutant of Podospora anserina.
Sainsard-Chanet et al., Gif-sur-Yvette, France. In Fungal Genet Biol, Sep 2015
It is a loss-of-function mutation in the gene encoding the MED13 subunit of the kinase module of the Mediator complex.
Mediator kinase module and human tumorigenesis.
Boyer et al., San Antonio, United States. In Crit Rev Biochem Mol Biol, 2014
In humans, MED13, MED12, CDK8 and Cyclin C (CycC) comprise a four-subunit "kinase" module that exists in variable association with a 26-subunit Mediator core.
Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer.
Roninson et al., Columbia, United States. In Curr Cancer Drug Targets, 2014
CDK8 and its paralog CDK19, in complex with CCNC, MED12 and MED13, are transcriptional regulators that mediate several carcinogenic pathways and the chemotherapy-induced tumor-supporting paracrine network.
MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver.
Olson et al., Dallas, United States. In Embo Mol Med, 2014
We previously showed that cardiac MED13 modulates systemic energy homeostasis in mice.
The Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions.
Poethig et al., Irapuato, Mexico. In Development, 2014
We have previously shown that two components of the Mediator CDK8 module encoded by CENTER CITY (CCT; Arabidopsis MED12) and GRAND CENTRAL (GCT; Arabidopsis MED13) are required for timing of pattern formation during embryogenesis.
Heart over mind: metabolic control of white adipose tissue and liver.
Sadoshima et al., Newark, United States. In Embo Mol Med, 2014
Olson and colleagues previously demonstrated that miR‐208a controls systemic energy homeostasis through the regulation of MED13 in cardiomyocytes (Grueter et al, 2012).
Mediator can regulate mitotic entry and direct periodic transcription in fission yeast.
Gustafsson et al., Göteborg, Sweden. In Mol Cell Biol, 2014
Deletion of Mediator components Med12 and Med13 leads to higher cellular Cdk8 protein levels, premature phosphorylation of the Cdk8 target Fkh2, and earlier entry into mitosis.
CYCLIN-DEPENDENT KINASE8 differentially regulates plant immunity to fungal pathogens through kinase-dependent and -independent functions in Arabidopsis.
Mengiste et al., Chinju, South Korea. In Plant Cell, 2014
In addition, overlapping functions of CDK8 with MED12 and MED13 and interactions between CDK8 and C-type cyclins suggest the conserved configuration of the plant Mediator kinase module.
Med13p prevents mitochondrial fission and programmed cell death in yeast through nuclear retention of cyclin C.
Strich et al., Stratford, Canada. In Mol Biol Cell, 2014
Deleting MED13 allows aberrant cytoplasmic cyclin C localization and extensive mitochondrial fragmentation.
Heart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila.
Olson et al., Dallas, United States. In Proc Natl Acad Sci U S A, 2014
We reported previously that MED13, a subunit of the Mediator complex, acts in the heart to control obesity in mice.
The roles of mediator complex in cardiovascular diseases.
Napoli et al., Napoli, Italy. In Biochim Biophys Acta, 2014
Nowadays, also MED13 and MED15 have been associated with human congenital heart diseases and others could be added, like MED12 that is involved in early mouse development and heart formation.
New perspectives on the diversification of the RNA interference system: insights from comparative genomics and small RNA sequencing.
Aravind et al., Bethesda, United States. In Wiley Interdiscip Rev Rna, 2014
Structural dissection of PIWI proteins along with recent discovery of novel families (including Med13 of the Mediator complex) suggest that emergence of a distinct architecture with the N-terminal domains (also occurring separately fused to endoDNases in prokaryotes) formed via duplication of an ancestral unit was key to their recruitment as primary RNAi effectors and use of small RNAs of certain preferred lengths.
A cardiac microRNA governs systemic energy homeostasis by regulation of MED13.
Olson et al., Dallas, United States. In Cell, 2012
We show that the heart regulates systemic energy homeostasis via MED13, a subunit of the Mediator complex, which controls transcription by thyroid hormone and other nuclear hormone receptors.
The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.
Taatjes et al., Boulder, United States. In Genes Dev, 2009
Med12 and Med13 are critical for human CDK8 subcomplex -dependent repression, whereas CDK8 kinase activity is not
Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13.
Treisman et al., New York City, United States. In Proc Natl Acad Sci U S A, 2008
Pygopus promotes Wnt target gene transcription by recruiting the mediator complex through interactions with Med12 and Med13.
Drosophila TRAP230/240 are essential coactivators for Atonal in retinal neurogenesis.
Choi et al., Houston, United States. In Dev Biol, 2007
Kto/Skd act as essential coactivators for Ato expression during early retinal neurogenesis.
Two subunits of the Drosophila mediator complex act together to control cell affinity.
Treisman et al., New York City, United States. In Development, 2003
Data show that both sklud and kohtalo are required to establish normal cell affinity differences at the anterior-posterior and dorsal-ventral compartment boundaries of the wing disc.
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