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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Translin, TB-RBP
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RBP, CAN, ACID, DISC1, POLYMERASE
Papers on Translin
Clozapine influences cytoskeleton structure and calcium homeostasis in rat cerebral cortex and has a different proteomic profile than risperidone.
Dziedzicka-Wasylewska et al., Kraków, Poland. In J Neurochem, Mar 2015
Moreover, risperidone increased the level of proteins involved in cell proliferation such as fatty acid-binding protein-7 and translin-associated factor X. CLO significantly up-regulated the expression of visinin-like protein 1, neurocalcin δ and mitochondrial, stomatin-like protein 2, the calcium-binding proteins regulating calcium homeostasis, and the functioning of ion channels and receptors.
A novel open-barrel structure of octameric translin reveals a potential RNA entryway.
Alian et al., Haifa, Israel. In J Mol Biol, Mar 2015
The single-stranded DNA (ssDNA)/RNA binding protein translin was suggested to be involved in chromosomal translocations, telomere metabolism, and mRNA transport and translation.
Globo-H ceramide shed from cancer cells triggers translin-associated factor X-dependent angiogenesis.
Yu et al., Taipei, Taiwan. In Cancer Res, 2015
Tumor angiogenesis is a critical element of cancer progression, and strategies for its selective blockade are still sought.
ABCE1 is a highly conserved RNA silencing suppressor.
Sarmiento et al., Tallinn, Estonia. In Plos One, 2014
In addition, one of the identified proteins is translin, which together with its binding partner TRAX supports RNA interference.
Identification of chimeric TSNAX-DISC1 resulting from intergenic splicing in endometrial carcinoma through high-throughput RNA sequencing.
Zhou et al., Stanford, United States. In Carcinogenesis, 2014
Here, by high-throughput RNA sequencing in nine paired human endometrial carcinoma (EC) and matched non-cancerous tissues, we obtained that chimeric translin-associated factor X-disrupted-in-schizophrenia 1 (TSNAX-DISC1) occurred significantly upregulated in multiple EC samples.
DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy.
Fañanás et al., Barcelona, Spain. In J Affect Disord, 2014
Among promising candidate genes, distrupted in schizophrenia 1 (DISC1), translin-associated factor X (TSNAX) and D-amino acid oxidase activator (DAOA) were suggested since their regulator role in neurodevelopment, neuroplasticity and neurotransmission, and previous evidence of cross-involvement in major psychiatric diseases.
Characterization of a plant (rice) translin and its comparative analysis with human translin.
Ballal et al., Mumbai, India. In Planta, 2014
MAIN CONCLUSION: For the first time, a plant (rice) translin was characterized.
Hydrolysis rates of different small interfering RNAs (siRNAs) by the RNA silencing promoter complex, C3PO, determines their regulation by phospholipase Cβ.
Scarlata et al., Stony Brook, United States. In J Biol Chem, 2014
C3PO consists of two subunits of the endonuclease translin-associated factor X (TRAX) and six subunits of the nucleotide-binding protein translin.
Conformational transitions in human translin enable nucleic acid binding.
Fernández-Recio et al., Montpellier, France. In Nucleic Acids Res, 2013
Translin is a highly conserved RNA- and DNA-binding protein that plays essential roles in eukaryotic cells.
Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells.
Kleene, Boston, United States. In Reproduction, 2013
As a result, the mechanisms involving well-studied mRNAs (Ddx4/Mvh, Prm1, Prm2, and Sycp3) and factors (DICER1, CPEB1, DAZL, DDX4/MVH, DDX25/GRTH, translin, and ELAV1/HuR) are incompletely understood.
Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review.
Blackwood et al., Edinburgh, United Kingdom. In Schizophr Res, 2013
DISC1 interactions with translin-associated factor X (TRAX) and neuregulin have been shown to influence several regional volumes.
The pathological phenotypes of human TDP-43 transgenic mouse models are independent of downregulation of mouse Tdp-43.
Zhang et al., Jacksonville, United States. In Plos One, 2012
In elucidating the role of mTdp-43 and hTDP-43 in hTDP-43 transgenic mice, we observed that reduction of mTdp-43 in non-transgenic mice by intraventricular brain injection of AAV1-shTardbp leads to a dramatic increase in the levels of splicing variants of mouse sortilin 1 and translin.
Identification of nucleic acid binding sites on translin-associated factor X (TRAX) protein.
Kumar et al., Mumbai, India. In Plos One, 2011
Translin B3 motif, corresponding to TRAX B3 residues, contributes towards its DNA binding activity.
Structure of C3PO and mechanism of human RISC activation.
Zhang et al., Dallas, United States. In Nat Struct Mol Biol, 2011
C3PO endonuclease is an asymmetric octamer barrel consisting of six translin and two TRAX subunits which activates RISC by degrading the Ago2-nicked passenger strand of siRNA.
Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex.
Patel et al., New York City, United States. In Nat Struct Mol Biol, 2011
These studies establish that Trax adopts the translin fold, possesses catalytic centers essential for C3PO's endoRNase activity and interacts extensively with translin to form an octameric assembly.
From cradle to twilight: the carboxyl terminus directs the fate of the A(2A)-adenosine receptor.
Freissmuth et al., Vienna, Austria. In Biochim Biophys Acta, 2011
The list includes the deubiquinating enzyme USP4, α-actinin, the guanine nucleotide exchange factor for ARF6 ARNO, translin-X-associated protein, calmodulin, the neuronal calcium binding protein NECAB2 and the synapse associated protein SAP102.
Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms.
Baraban et al., Baltimore, United States. In J Neurochem, 2011
These in vivo and in vitro findings of this study indicated that dendritic trafficking of BDNF mRNA can be mediated by both translin-dependent and -independent mechanisms.
Biological roles of translin and translin-associated factor-X: RNA metabolism comes to the fore.
McFarlane et al., Bangor, United Kingdom. In Biochem J, 2010
Translin, and its binding partner protein TRAX (translin-associated factor-X) are a paralogous pair of conserved proteins, which have been implicated in a broad spectrum of biological activities, including cell growth regulation, mRNA processing, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis, although their precise role in some of these processes remains unclear.
Analysis of nucleic acid binding by a recombinant translin-trax complex.
Robertus et al., Austin, United States. In Biochem Biophys Res Commun, 2010
trax acts to regulate translin's RNA and DNA binding affinities as part of a cellular RNA trafficking mechanism.
The A(2A)-adenosine receptor: a GPCR with unique features?
Freissmuth et al., Vienna, Austria. In Br J Pharmacol, 2008
Established interaction partners include alpha-actinin, ARNO, USP4 and translin-associated protein-X.
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