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Transcription factor Dp-1

Transcription Factor DP1, arylsulfatase, DP1, As I, AS1
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, CRTH2
Papers using Transcription Factor DP1 antibodies
Nielen M. W. F. et al., In Analytical and Bioanalytical Chemistry, 2003
... Ethyl acetate, formic acid, acetic acid and β-glucuronidase/arylsulfatase (from Helix pomatia) were purchased from Merck (Amsterdam, The Netherlands) ...
Papers on Transcription Factor DP1
Lacritin and other autophagy associated proteins in ocular surface health.
Laurie et al., Hyderābād, India. In Exp Eye Res, Mar 2016
Mutation of arylsulfatase A, arylsulfatase B, ceroid-lipofuscinosis neuronal 3, mucolipin, or Niemann-Pick disease type C1 respectively underlie several diseases of apparently insufficient autophagic flux that affect the eye, including: metachromatic leukodystrophy, mucopolysaccharidosis type VI, juvenile-onset Batten disease, mucolipidosis IV, and Niemann-Pick type C associated with myelin sheath destruction of corneal sensory and ciliary nerves and of the optic nerve; corneal clouding, ocular hypertension, glaucoma and optic nerve atrophy; accumulation of 'ceroid-lipofuscin' in surface conjunctival cells, and in ganglion and neuronal cells; decreased visual acuity and retinal dystrophy; and neurodegeneration.
Genome-wide methylation profiling identifies novel methylated genes in neuroblastoma tumors.
Carén et al., Göteborg, Sweden. In Epigenetics, Feb 2016
The genes with the highest number of hypermethylated CpG sites in INRG M tumors are TERT, PCDHGA4, DLX5, and DLX6-AS1.
The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication in C. elegans.
O'Connell et al., In G3 (bethesda), Feb 2016
UNASSIGNED: Centrioles play critical roles in the organization of microtubule-based structures from the mitotic spindle to cilia, and flagella.
Assessing the fatty acid, carotenoid, and tocopherol compositions of amaranth and quinoa seeds grown in Ontario and their overall contribution to nutritional quality.
Tsao et al., In J Agric Food Chem, Feb 2016
All of the amaranth seeds demonstrated lower overall lipophilic quality than quinoa, with the AS1 and QS10 cultivars providing the highest scores for amaranth and quinoa seeds respectively.
High expression of long non-coding RNA AFAP1-AS1 predicts chemoradioresistance and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy.
Tong et al., Nanjing, China. In Mol Carcinog, Feb 2016
Three lncRNAs (AFAP1-AS1, UCA1, HOTAIR) were found to be deregulated in cisplatin-resistant cells compared with their parent cells.
Mutation Update of ARSA and PSAP Genes Causing Metachromatic Leukodystrophy.
Biffi et al., Milano, Italy. In Hum Mutat, Jan 2016
The disease is caused by variants in the ARSA gene, which codes for the lysosomal enzyme arylsulfatase A, or, more rarely, in the PSAP gene, which codes for the activator protein saposin B. In this Mutation Update, an extensive review of all the ARSA- and PSAP-causative variants published in the literature to date, accounting for a total of 200 ARSA and 10 PSAP allele types, is presented.
IFT-Cargo Interactions and Protein Transport in Cilia.
Lechtreck, Athens, United States. In Trends Biochem Sci, Dec 2015
Smaller, freely diffusing proteins, such as tubulin, depend on IFT to be concentrated or removed from cilia.
Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System.
Yamamoto et al., Himeji, Japan. In Mol Neurobiol, Oct 2015
PGD2, PGE2, and PGI2 exhibit neuroprotective effects via Gs-coupled DP1, EP2/EP4, and IP receptors, respectively.
From the concept of totipotency to biofortified cereals.
Potrykus, Zürich, Switzerland. In Annu Rev Plant Biol, 2014
From my cell culture experience, I had reasons not to trust Agrobacterium for that purpose, and I developed direct gene transfer instead.
An Updated Review on the Genetics of Primary Open Angle Glaucoma.
Chalam et al., Riyadh, Saudi Arabia. In Int J Mol Sci, 2014
Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) at different loci including CAV1/CAV2, TMCO1, CDKN2B-AS1, CDC7-TGFBR3, SIX1/SIX6, GAS7 and ATOH7 to be associated with POAG and its related quantitative traits (endophenotypes).
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy.
Naldini et al., Milano, Italy. In Science, 2013
Metachromatic leukodystrophy (MLD) is an inherited lysosomal storage disease caused by arylsulfatase A (ARSA) deficiency.
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
Slager et al., Bethesda, United States. In Nat Genet, 2013
In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P=1.22×10(-14)), 18q21.33 (BCL2, P=7.76×10(-11)), 11p15.5 (C11orf21, P=2.15×10(-10)), 4q25 (LEF1, P=4.24×10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P=2.50×10(-9)), 9p21.3 (CDKN2B-AS1, P=1.27×10(-8)), 18q21.32 (PMAIP1, P=2.51×10(-8)), 15q15.1 (BMF, P=2.71×10(-10)) and 2p22.2 (QPCT, P=1.68×10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P=2.08×10(-18)).
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Murakami et al., Tokyo, Japan. In Nat Immunol, 2013
PLA2G3 secreted from mast cells is coupled with fibroblastic lipocalin-type PGD2 synthase (L-PGDS) to provide PGD2, which facilitates mast-cell maturation via PGD2 receptor DP1.
Identification of multiple independent susceptibility loci in the HLA region in Behçet's disease.
Sawalha et al., Ann Arbor, United States. In Nat Genet, 2013
Three additional independent genetic associations within PSORS1C1 (rs12525170: OR = 3.01, P = 3.01 × 10(-26)), upstream of HLA-F-AS1 (rs114854070: OR = 1.95,
D-type prostanoid receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on T(H)2 cells.
Waldhoer et al., Graz, Austria. In J Allergy Clin Immunol, 2012
DP receptors amplify the biological response to CRTH2 activation and the CRTH2/DP heteromer might represent both a functional signaling unit for PGD(2) and a potential target for development of heteromer-directed therapy for allergic diseases
Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis.
Ferrándiz et al., Valencia, Spain. In Arthritis Rheum, 2012
PGD2 is produced in articular tissue during the development of collagen-induced arthritis and plays an antiinflammatory role, acting through the DP1 receptor.
PTGDR gene in asthma: a functional, genetic, and epigenetic study.
Dávila et al., Salamanca, Spain. In Allergy, 2011
Genetic combinations described have functional implications in the PTGDR promoter activity by changing the transcription factors affinity that will help characterize different risk groups.
The extracellular signal-regulated kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP response element-binding protein to induce MUC5B gene expression via D-prostanoid receptor signaling.
Yoon et al., Seoul, South Korea. In J Biol Chem, 2011
PGD(2) can induce MUC5B overproduction via ERK MAPK/RSK1/CREB signaling and that DP1 receptor may have suppressive effects in controlling MUC5B overproduction in the airway.
No association of PTGDR -441C/T polymorphism with asthma in a North Indian population.
Batra et al., Chandīgarh, India. In Dis Markers, 2010
The PTGDR -441C/T polymorphism is not associated with asthma or its phenotypes in the North Indian population.
Isolation, Characterization and Identification of a Potential Probiont from South Indian Fermented Foods (Kallappam, Koozh and Mor Kuzhambu) and Its Use as Biopreservative.
Arul et al., Pondicherry, India. In Probiotics Antimicrob Proteins, 2010
Lactobacillus plantarum AS1 showed maximum antimicrobial activity among 6 strains and this strain was chosen for biopreservation.
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