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TNF receptor-associated factor 2

TRAF2, TNF Receptor-Associated Factor 2, GRP94, gp96, TRA-1
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, GRP78, V1a, PrP, Nanog
Papers using TRAF2 antibodies
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
Leverkus Martin et al., In The Journal of Cell Biology, 2008
... Polyclonal antibodies to HMGB-1 were purchased from Abcam, and TRAF2 (C-20) and CD95 antibodies (C-20) were purchased from Santa Cruz Biotechnology, Inc ...
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα
Silke John et al., In The Journal of Cell Biology, 2006
... used for Western blots were Goat anti–human IgG HRP (Jackson ImmunoResearch Laboratories), anti-cIAP1 (in house), anti-TRAF2 (Santa Cruz Biotechnology, Inc.), anti-FN14 (Cell Signaling ...
A proteomic screen identified stress-induced chaperone proteins as targets of Akt phosphorylation in mesangial cells.
Cheriyath Venugopalan, In PLoS ONE, 2005
... Anti-GRP94 and Anti-HSP40 antibodies were from Abcam (Cambridge, UK) ...
Human embryonic stem cell lines with genetic disorders
Lavon Neta et al., In In Vitro Cellular & Developmental Biology. Animal, 2004
... As primary antibodies, we used mouse IgG anti-human OCT-3/4, mouse IgM anti-human TRA-1-60 (Santa Cruz Biotechnology Inc, Santa Cruz, CA) ...
Membrane HSP70: the molecule triggering γδ T cells in the early stage of tumorigenesis
Lin Huanping et al., In Clinical and Developmental Immunology, 2004
... HSP72 monoclonal antibody was obtained from StressGen Biotechnologies (Victoria, British Columbia, Canada) and mouse antihuman gp96 monoclonal antibody was purchased from Santa Cruz Biotechnology, Inc (Santa Cruz, CA, ...
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Papers on TRAF2
Comparison of the peptide binding preferences of three closely related TRAF paralogs: TRAF2, TRAF3, and TRAF5.
Keating et al., Cambridge, United States. In Protein Sci, Feb 2016
We displayed single- and double-mutant peptide libraries based on the TRAF binding sites of CD40 or TANK on the surface of Escherichia coli and screened them for binding to TRAF2, TRAF3, and TRAF5.
Involvement of Endoplasmic Reticulum Stress in Uremic Cardiomyopathy: Protective Effects of Tauroursodeoxycholic Acid.
Gu et al., Shanghai, China. In Cell Physiol Biochem, Feb 2016
ERS markers (GRP78, GRP94, P-PERK, P-eIF2a) and ERS-induced apoptosis pathways (activation of CHOP and caspase-12) were increased significantly in 5/6 nephrectomy mice, and TUDCA treatment blunted these changes.
The Immunohistochemical Evaluation of Solid Pseudopapillary Tumors of the Pancreas and Pancreatic Neuroendocrine Tumors Reveals ERO1Lβ as a New Biomarker.
Peng et al., Shanghai, China. In Medicine (baltimore), Jan 2016
We performed immunohistochemistry (IHC) for 6 representative proteins (ERO1Lβ, TRAM1, GRP94, BIP, P4HB, and PDIA4) involved in the ER pathway in both SPTP and PNET specimens.
Proinflammatory gene expression in patients undergoing mitral valve surgery and maze ablation for atrial fibrillation.
Yeh et al., Taiwan. In J Thorac Cardiovasc Surg, Jan 2016
Concordant with the gene expression difference between AF and SR patients, rapid pacing increased the expressions of SHC1, RHOA, PDGFA, and TRAF2 in HL-1 myocytes, implicating a causative effect of tachyarrhythmia on these genes.
Identification of Top-ranked Proteins within a Directional Protein Interaction Network using the PageRank Algorithm: Applications in Humans and Plants.
Du et al., Fredericton, Canada. In Curr Issues Mol Biol, Jan 2016
Eight proteins (ACVR1, CDC42, RAC1, RAF1, RHOA, TGFBR1, TRAF2, and TRAF6) are ranked in the top 50 key players in both signal emission and signal reception and in interaction with many other proteins.
ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors.
Miaczynska et al., Warsaw, Poland. In Sci Signal, Dec 2015
Endosomal accumulation of LTβR induced its ligand-independent oligomerization and signaling through the adaptors TNFR-associated factor 2 (TRAF2) and TRAF3.
Targeting the Wnt signaling pathway in colorectal cancer.
Yamada et al., Kōbe, Japan. In Expert Opin Ther Targets, Nov 2015
TRAF2 and NCK-interacting protein kinase (TNIK) was identified as the most downstream regulator of Wnt signaling by two independent research groups, and several classes of small-molecule inhibitors targeting this protein kinase have been developed.
Targeting signaling factors for degradation, an emerging mechanism for TRAF functions.
Sun et al., Shanghai, China. In Immunol Rev, Jul 2015
However, emerging evidence suggests that TRAF proteins, particularly TRAF2 and TRAF3, also regulate signal transduction by controlling the fate of intracellular signaling factors.
Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis.
Lee et al., Los Angeles, United States. In J Cell Physiol, Jul 2015
This review highlights recent progress towards the understanding of the role of the UPR and two major GRPs (GRP78 and GRP94) in regulating homeostasis of organs arising from the endoderm, mesoderm and ectoderm.
The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-κB signaling.
Lin et al., Taipei, Taiwan. In Apoptosis, Feb 2015
The CARD subfamily contains 33 human CARD-containing proteins, regulating the assembly of many signaling complexes, including apoptosome, inflammsome, nodosome, the CBM complex, PIDDosome, the TRAF2 complex, and the MAVS signalosome, by homotypic CARD-CARD interactions.
Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.
Stegmeier et al., Cambridge, United States. In Nat Med, 2014
Transcriptome sequencing revealed genetic lesions in alternative NF-κB pathway signaling components in ibrutinib-insensitive cell lines, and sequencing of 165 samples from patients with MCL identified recurrent mutations in TRAF2 or BIRC3 in 15% of these individuals.
Human phospholipid scramblase 1 interacts with and regulates transactivation of HTLV-1 Tax.
Eizuru et al., Kagoshima, Japan. In Virology, 2012
PLSCR1 may play an important role in the IFN-mediated repression of Tax-dependent transactivation during HTLV-1 infection.
TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.
Takeuchi et al., Suita, Japan. In J Biol Chem, 2012
TANK is critical for osteoclastogenesis by regulating NF-kappaB, and is also important for proper bone remodeling.
TNFR-associated factor 2 deficiency in B lymphocytes predisposes to chronic lymphocytic leukemia/small lymphocytic lymphoma in mice.
Zapata et al., Madrid, Spain. In J Immunol, 2012
Expression of endogenous TRAF2 is negligible in Traf2DN-transgenic B cells compared with wild-type mice.
Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome.
Saleh et al., Montréal, Canada. In Immunity, 2012
cIAP1, cIAP2, and the adaptor protein TRAF2 interacted with caspase-1-containing complexes and mediated the activating nondegradative K63-linked polyubiquitination of caspase-1.
Upregulation of Gp96 correlates with the radiosensitivity and five-year survival rate of nasopharyngeal carcinoma.
Zhang et al., Beijing, China. In Orl J Otorhinolaryngol Relat Spec, 2011
Patients with high Gp96 expression levels were significantly more resistant to radiotherapy in nasopharyngeal carcinoma.
Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF).
Hamilton et al., Cleveland, United States. In Nat Immunol, 2011
We show here that IL-17 enhanced the stability of chemokine CXCL1 mRNA and other mRNAs through a pathway that involved the adaptor Act1, the adaptors TRAF2 or TRAF5 and the splicing factor SF2 (also known as alternative splicing factor (ASF)).
The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation.
Li et al., Cleveland, United States. In Nat Immunol, 2011
IKKi deficiency abolished IL-17-induced formation of the complex of Act1 and the adaptors TRAF2 and TRAF5, activation of mitogen-activated protein kinases (MAPKs) and mRNA stability, whereas the Act1-TRAF6-transcription factor NF-κB axis was retained.
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.
Spiegel et al., Richmond, United States. In Nature, 2010
data show that TRAF2 is a novel intracellular target of S1P, and that S1P is the missing cofactor for TRAF2 E3 ubiquitin ligase activity, indicating a new paradigm for the regulation of lysine-63-linked polyubiquitination
More papers using TRAF2 antibodies
AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation
Molinari Maurizio et al., In The Journal of Cell Biology, 2003
... Antibodies to BiP, EDEM1, and GRP94 were obtained from Santa Cruz Biotechnology, Inc., Sigma-Aldrich, and Thermo ...
Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis
Grimm Stefan et al., In Cell Death and Differentiation, 2002
... Monoclonal antibodies against RIP1, TRAF2 and FADD were purchased from BD Biosciences (UK) ...
Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription
Glimcher Laurie H. et al., In The Journal of Experimental Medicine, 2000
... TRAF2.DN transgenic mice (which overexpress a lymphocyte-specific ...
Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
Vandenberghe Wim et al., In The European Journal of Neuroscience, 1999
... Transduction Laboratories; rabbit anti-Hsp70 was from Stressgen; polyclonal goat anti-DJ-1, rabbit anti-IKKγ (FL-419) and rabbit anti-TRAF2 (C-20) were from Santa Cruz Biotechnology; rabbit anti-BAG5 was from ...
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