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Transformer 2 beta homolog

Tra2beta, htra2-beta, RA301, SFRS10
This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: CAN, Omi, V1a, ACID, iMpact
Papers on Tra2beta
Knocking down the expression of TRA2β inhibits the proliferation and migration of human glioma cells.
Cui et al., Suzhou, China. In Pathol Res Pract, Oct 2015
TRA2β protein is encoded by the TRA2B gene (also called SFRS10) on human chromosome 3.
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
Zhou et al., Shijiazhuang, China. In Alcohol Alcohol, Mar 2015
RESULT: Ethanol could increase the expression of lipin-1 through the AMPK-SREBP-1 signaling and dramatically increase the ratio of Lpin1β to Lpin1α by SIRT1-SFRS10-Lpin1β/α axis in the liver.
Transformer 2β (Tra2β/SFRS10) positively regulates the progression of NSCLC via promoting cell proliferation.
Wang et al., Nantong, China. In J Mol Histol, 2014
Transformer 2β (Tra2β), a member of the serine/arginine-rich-like protein family, is an important RNA-binding protein involved in alternative splice.
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
You et al., Barcelona, Spain. In Gastroenterology, 2014
We also measured messenger RNA levels of SIRT1, SFRS10, and lipin-1β and lipin-1α in liver samples from patients with alcoholic hepatitis and individuals without alcoholic hepatitis (controls).
Splicing factor TRA2B is required for neural progenitor survival.
Chen et al., Santa Cruz, United States. In J Comp Neurol, 2014
The RNA binding protein TRA2B (SFRS10) plays well-established roles in developmentally regulated alternative splicing during Drosophila sexual differentiation.
Expression analysis of an evolutionarily conserved alternative splicing factor, Sfrs10, in age-related macular degeneration.
Kanadia et al., United States. In Plos One, 2012
Here, we investigated the expression of a known stress response gene and an alternative splicing factor called Serine-Arginine rich splicing factor 10 (Sfrs10).
Tra2β protein is required for tissue-specific splicing of a smooth muscle myosin phosphatase targeting subunit alternative exon.
Fisher et al., Cleveland, United States. In J Biol Chem, 2012
Tra2beta, by regulating the splicing of Mypt1 E23, sets the sensitivity of smooth muscle to cGMP-mediated relaxation.
The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B.
Black et al., Los Angeles, United States. In Rna, 2012
Within and adjacent to these regulated exons, we identified enrichment of potential binding sites for the splicing factors SRp20 (SRSF3/SFRS3) and Tra2-β (SFRS10/TRA2B).
Response to Brosch et al.
Patti et al., Boston, United States. In Cell Metab, 2012
UNASSIGNED: We would like to respond to Brosch et al. regarding our manuscript "Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis" (Pihlajamäki et al., 2011b).
Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development.
Elliott et al., Newcastle upon Tyne, United Kingdom. In Plos Genet, 2011
Normal activation of these regulated exons depends on multiple Tra2b binding sites, and significant mis-regulation of these exons is observed during mouse development when Tra2b is removed.
Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.
Patti et al., Boston, United States. In Cell Metab, 2011
reduced expression of SFRS10, as observed in tissues from obese humans, alters LPIN1 splicing, induces lipogenesis, and therefore contributes to metabolic phenotypes associated with obesity.
Expression levels of hnRNP G and hTra2-beta1 correlate with opposite outcomes in endometrial cancer biology.
Stickeler et al., Freiburg, Germany. In Int J Cancer, 2011
nuclear hnRNP G level as well as hTra2-beta1 level were independent prognostic factors for endometrial cancer progression-free survival
Structural basis for the dual RNA-recognition modes of human Tra2-β RRM.
Muto et al., Yokohama, Japan. In Nucleic Acids Res, 2011
Results indicates that the Human Transformer2-beta RNA recognition motif recognizes two types of RNA sequences in different RNA binding modes.
Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing.
Wirth et al., Köln, Germany. In Hum Mol Genet, 2010
The SR-like splicing factor SFRS10 (Htra2-beta1) is well known to influence various alternatively spliced exons without being an essential splicing factor.
Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population.
Lam et al., Hong Kong, Hong Kong. In J Clin Endocrinol Metab, 2010
These included GNPDA2 rs10938397 (P = 7.3 x 10(-4)); FTO rs8050136 (P = 8 x 10(-4)); MC4R rs17782313 (P = 1.2 x 10(-3)); KCTD15 rs29941 (P = 8 x 10(-3)); SFRS10-ETV5-DGKG rs7647305 (P = 0.023); SEC16B-RASAL2 rs10913469 (P = 0.041); and NEGR1 rs3101336 (P = 0.046).
Oxidative stress-induced alternative splicing of transformer 2beta (SFRS10) and CD44 pre-mRNAs in gastric epithelial cells.
Rokutan et al., Tokushima, Japan. In Am J Physiol Cell Physiol, 2009
Results suggest that Tra2beta may regulate cellular oxidative response by changing alternative splicing of distinct genes including CD44.
Single molecule profiling of tau gene expression in Alzheimer's disease.
Hyman et al., United States. In J Neurochem, 2007
Additional investigations of cis and trans mechanisms of this observation revealed a decreased protein expression of a known tau splicing factor, htra2-beta-1 in AD, thereby implicating a trans mechanism.
Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2.
Elliott et al., Newcastle upon Tyne, United Kingdom. In J Cell Sci, 2007
We found that SAFB2 protein, like SAFB1, acts as a negative regulator of a tra2beta variable exon.
A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways.
Schultz et al., Los Angeles, United States. In Biochemistry, 2007
Selective depletion of some of these proteins, including RNA binding proteins SRRM2, SFRS1, SFRS9, and SFRS10, by siRNAs reduced the rate of migration of ErbB2-overexpressing ovarian cancer cells.
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