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Cysteine-rich secretory protein 2

Tpx-1, CRISP2, Cysteine-rich secretory protein 2
testicular cell adhesion molecule; mediates interaction between spermatogenic and Sertoli cells [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, ARP, CAN, Thioredoxin, HAD
Papers on Tpx-1
Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: Implications for fertility disorders.
CuasnicĂș et al., Buenos Aires, Argentina. In Mol Hum Reprod, Feb 2016
STUDY HYPOTHESIS: We hypothesize that fertility disorders in patients with aberrant expression of Cysteine-RIch Secretory Protein 2 (CRISP2) could be linked to the proposed functional role of this protein in fertilization.
From the epididymis to the egg: participation of CRISP proteins in mammalian fertilization.
Cuasnicu et al., Buenos Aires, Argentina. In Asian J Androl, Sep 2015
Evidence supports that other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4) or during ejaculation (CRISP3) are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization.
Effect of thioredoxin peroxidase-1 gene disruption on the liver stages of the rodent malaria parasite Plasmodium berghei.
Kawazu et al., Obihiro, Japan. In Parasitol Int, Jun 2015
Phenotypic observation of thioredoxin peroxidase-1 (TPx-1) gene-disrupted Plasmodium berghei (TPx-1 KO) in the liver-stage was performed with an in vitro infection system in order to investigate defective liver-stage development in a mouse infection model.
Ectopic expression of Arabidopsis RCI2A gene contributes to cold tolerance in tomato.
Girija et al., Coimbatore, India. In Transgenic Res, Apr 2015
A motif search revealed that the motifs of photosystem II (PSII) phosphoproteins PsbJ and PsbH and reaction-center proteins PsbL and PsbK were common to cold-inducible RCI2A and peroxidase proteins RCI3A, tomato peroxidase (TPX1), TPX2, tomato ascorbate peroxidase (APX1), and horseradish peroxidase (HRP-c).
A Comprehensive Expression Analysis of Cancer Testis Antigens in Head and Neck Squamous Cell Carcinoma Revels MAGEA3/6 as a Marker for Recurrence.
Vettore et al., Diadema, Brazil. In Mol Cancer Ther, Mar 2015
The mRNA positivity of CXORF48, MAGEB6, and CRISP2 presented significant associations with recognized clinical features for poor outcome.
The expression of cysteine-rich secretory protein 2 (CRISP2) and its specific regulator miR-27b in the spermatozoa of patients with asthenozoospermia.
Liu et al., Guangzhou, China. In Biol Reprod, 2015
Cysteine-rich secretory protein 2 (CRISP2) is an important sperm protein and plays roles in spermatogenesis, modulation of flagellar motility, acrosome reaction, and gamete fusion.
Major protein alterations in spermatozoa from infertile men with unilateral varicocele.
Sabanegh et al., Cleveland, United States. In Reprod Biol Endocrinol, 2014
Proteins expressed uniquely in the unilateral varicocele group were cysteine-rich secretory protein 2 precursor (CRISP2) and arginase-2 (ARG2).
[Expression of cysteine-rich secretory protein 2 in patients with asthenozoospermia and its clinical significance].
Liu et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2014
OBJEVTIVE: To investigate the expression of cysteine-rich secretory protein 2 (CRISP2) in spermatozoa of patients with asthenozoospermia and explore its clinical significance.
Detecting coevolution in mammalian sperm-egg fusion proteins.
Swanson et al., Seattle, United States. In Mol Reprod Dev, 2014
With regression analysis, we found that CD9 and CRISP2 have correlated rates of evolution, and with likelihood analysis, that CD9 and CRISP1 have correlated rates.
Meta-analysis of human methylation data for evidence of sex-specific autosomal patterns.
Hewitt et al., Perth, Australia. In Bmc Genomics, 2013
Of note was differential CpG methylation in the promoters of genes thought to be involved in spermatogenesis and male fertility, such as SLC9A2, SPESP1, CRISP2, and NUPL1.
The CAP protein superfamily: function in sterol export and fungal virulence.
Di Pietro et al., In Biomol Concepts, 2013
Expression of the mammalian CAP protein CRISP2, which binds sterols in vitro, complements the sterol export defect of a yeast pry mutant, suggesting that sterol binding and export is conserved among different CAP family members.
Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival.
Veal et al., Newcastle upon Tyne, United Kingdom. In Mol Cell, 2012
our data establish that redox-coupling between Trx1 and the thioredoxin peroxidase activity of Tpx1 is central for initiation of appropriate responses to different levels of hydrogen peroxide in S. pombe
[Expressions of cysteine-rich secretory protein 2 in asthenospermia].
Mao et al., Guangzhou, China. In Zhonghua Nan Ke Xue, 2011
The down-regulation of CRISP2 mRNA and protein expressions in the sperm of asthenospermia patients may be closely related with decreased sperm motility.
Cysteine-rich secretory proteins (CRISP) and their role in mammalian fertilization.
Cuasnicu et al., Buenos Aires, Argentina. In Biol Res, 2010
Evidence obtained in our laboratory indicated that testicular CRISP2 would also be involved in sperm-egg fusion.
Distinct functional roles of peroxiredoxin isozymes and glutathione peroxidase from fission yeast, Schizosaccharomyces pombe.
Kim et al., Kwangju, South Korea. In Bmb Rep, 2010
Thioredoxin Peroxidase inhibited thermal aggregation of citrate synthase, but BCP failed to inhibit the aggregation.
A novel protein, sperm head and tail associated protein (SHTAP), interacts with cysteine-rich secretory protein 2 (CRISP2) during spermatogenesis in the mouse.
O'Bryan et al., Melbourne, Australia. In Biol Cell, 2010
expression and localization of SHTAP in testis and sperm raise the possibility that the SHTAP-CRISP2 complex has a potential role in sperm formation and/or function.
Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis.
Kita et al., Rochester, United States. In Plos One, 2009
Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included decreased CRISP2&3.
Sperm-egg adhesion and fusion in mammals.
Sutovsky, Columbia, United States. In Expert Rev Mol Med, 2008
Additional proteins that may have nonessential yet still facilitating roles in sperm-oolemma adhesion and fusion include oolemma-anchored integrins and oocyte-expressed retroviral envelope proteins, sperm disintegrins, and sperm-borne proteins of epididymal origin such as CRISP1 and CRISP2.
Participation of cysteine-rich secretory proteins (CRISP) in mammalian sperm-egg interaction.
Cuasnicu et al., Buenos Aires, Argentina. In Int J Dev Biol, 2007
The observation that sperm testicular CRISP2 is also able to bind to the egg surface suggests a role for this protein in gamete fusion.
Molecular mechanisms involved in gamete interaction: evidence for the participation of cysteine-rich secretory proteins (CRISP) in sperm-egg fusion.
Cuasnicu et al., Buenos Aires, Argentina. In Soc Reprod Fertil Suppl, 2006
Epididymal protein DE and testicular protein Tpx-1 are two cysteine-rich secretory proteins also known as CRISP-1 and CRISP-2, respectively.
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