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Tryptophan hydroxylase 2

TPH2, tryptophan hydroxylase-2
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: tryptophan hydroxylase, HAD, ACID, CAN, AGE
Papers using TPH2 antibodies
SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression
Bartsch Dusan et al., In Frontiers in Molecular Neuroscience, 2003
... Generation of TPH2-CreERT2 transgenic mice ...
Co-regulation of two gene activities by tetracycline via a bidirectional promoter.
Bader Michael, In PLoS ONE, 1994
... For functional analysis of Ptet-controlled gene expression, TPH2-tTA mice were mated to homozygous Ptet-nLacZ (NZL2) mice [15] to generate double transgenic TPH2-tTA/Ptet-nLacZ mice ...
Papers on TPH2
The MAOA, COMT, MTHFR and ESR1 gene polymorphisms are associated with the risk of depression in menopausal women.
Jagodziński et al., Poznań, Poland. In Maturitas, Feb 2016
The following candidate genes were selected for the study: 5HTR2A, 5HTR1B, 5HTR2C, TPH1, TPH2, MAOA, COMT, NET, GABRB1, ESR1, MTHFR, MTR and MTHFD1.
Lipidomic profiling of tryptophan hydroxylase 2 knockout mice reveals novel lipid biomarkers associated with serotonin deficiency.
Liu et al., Beijing, China. In Anal Bioanal Chem, Feb 2016
This study therefore aimed to identify novel lipid biomarkers associated with serotonin deficiency by lipidomic profiling of tryptophan hydroxylase 2 knockout (Tph2-/-) mice.
Genetic variation in the tryptophan hydroxylase 2 gene moderates depressive symptom trajectories and remission over 8 weeks of escitalopram treatment.
Si et al., Beijing, China. In Int Clin Psychopharmacol, Feb 2016
The aim of this study was to investigate the relationship between genotypic variation in six candidate serotonergic genes (ADCY9, HTR1B, GNB3, HTR2A, TPH2, SLC6A4) and depressive and anxiety symptom severity trajectories as well as remission following escitalopram treatment.
Imaging genetics studies on monoaminergic genes in major depressive disorder.
Ham et al., Seoul, South Korea. In Prog Neuropsychopharmacol Biol Psychiatry, Feb 2016
This paper attempts to provide a comprehensive review of available imaging genetics studies, including reports on genetic variants that have most frequently been linked to MDD, such as the monoaminergic genes (serotonin transporter gene, monoamine oxidase A gene, tryptophan hydroxylase-2 gene, serotonin receptor 1A gene and catechol-O-methyl transferase gene), with regard to key structures involved in emotion processing, such as the hippocampus, amygdala, anterior cingulate cortex and orbitofrontal cortex.
Generation of serotonin neurons from human pluripotent stem cells.
Zhang et al., Madison, United States. In Nat Biotechnol, Jan 2016
The serotonin neurons express a series of molecules essential for serotonergic development, including tryptophan hydroxylase 2, exhibit typical electrophysiological properties and release serotonin in an activity-dependent manner.
Sex differences in the ontogeny of CRF receptors during adolescent development in the dorsal raphe nucleus and ventral tegmental area.
Andersen et al., In Synapse, Jan 2016
The serotonin and catecholamine enzymes in the DR and VTA, tryptophan hydroxylase 2 (TPH2) and tyrosine hydroxylase, respectively, were also analyzed for maturational differences.
Adaptive Plasticity in the Hippocampus of Young Mice Intermittently Exposed to MDMA Could Be the Origin of Memory Deficits.
Escubedo et al., Barcelona, Spain. In Mol Neurobiol, Jan 2016
The treatment did not modify hippocampal tryptophan hydroxylase 2, a serotonergic indicator, but induced an initial reduction in dopaminergic markers in substantia nigra, which remained stable for at least 3 months.
Tryptophan hydroxylase 2 in seasonal affective disorder: underestimated perspectives?
Popova et al., In Rev Neurosci, Jan 2016
Tryptophan hydroxylase 2 (TPH2) is the key and rate-limiting enzyme in 5-HT synthesis in the brain.
Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression.
Craske et al., Los Angeles, United States. In J Abnorm Psychol, Nov 2015
In a first demonstration of this approach in a G×E predicting depression, we created an additive multilocus profile score from 5 serotonin system polymorphisms (1 each in the genes HTR1A, HTR2A, HTR2C, and 2 in TPH2).
Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior.
Ames et al., Oakland, United States. In Faseb J, Jun 2015
Brain serotonin is synthesized from tryptophan by tryptophan hydroxylase 2, which is transcriptionally activated by vitamin D hormone.
Serotonergic gene variation in substance use pharmacotherapy: a systematic review.
Nielsen et al., Houston, United States. In Pharmacogenomics, 2014
Current evidence suggests that genetic variability of the serotonergic biosynthesis enzyme tryptophan hydroxylase 2 (TPH2) and the serotonin transporter (SLC6A4) genes mediates the efficacy of several addiction treatments, such as ondansetron and disulfiram, and the antidepressants bupropion, nortriptyline and sertraline.
Anti-Apoptotic Protein Bcl-xL Expression in the Midbrain Raphe Region Is Sensitive to Stress and Glucocorticoids.
Dygalo et al., Novosibirsk, Russia. In Plos One, 2014
Both short-term stress and acute DEX administration, in parallel with Bcl-xL, caused a significant increase in tph2 mRNA levels and slightly enhanced tryptophan hydroxylase immunoreactivity in the midbrain.
[Brain-derived neurotrophic factor: the influence on the genetically and epigenetically determined behavioral disorders].
Morozova et al., In Ross Fiziol Zh Im I M Sechenova, 2013
The review provides evidence that: 1) genes encoding key elements of the brain serotonergic system (tryptophan hydroxylase-2, 5-HT1A and 5-HT2A receptors) are implicated in the effect ofBDNF; 2) acute central administration of BDNF produced long-term ameliorative effects on some animal models of genetically defined behavior disorders; 3) BDNF decreased behavioral disorders induced by prenatal stress and ethanol exposure and may play an important role in the treatment of epigenetically defined pathological behavior.
Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients.
Elovaara et al., Tampere, Finland. In J Neuroimmunol, 2012
These data showing the association of polymorphisms in the TPH2 and MTNR1B genes with the progressive subtypes of multiple sclerosis and disability suggest dysregulation in melatonin pathway
Association with tryptophan hydroxylase 2 gene polymorphisms and autism spectrum disorders in Korean families.
Kim et al., Taejŏn, South Korea. In Neurosci Res, 2012
These results suggest that TPH2 polymorphisms enhance autism spectrum disorder susceptibility.
Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Commons et al., Boston, United States. In Brain Res, 2012
This study demonistrated that tph2 gene expression in mouse dorsal raphe nucleus.
Impact of tryptophan hydroxylase 2 G-703T polymorphism on anger-related personality traits and orbitofrontal cortex.
Ham et al., Seoul, South Korea. In Behav Brain Res, 2012
Genetic variation in TPH2 was associated with both anger and gray matter concentration in the inferior orbitofrontal cortex and hippocampus.
TPH2 gene polymorphisms and major depression--a meta-analysis.
Evangelou et al., Jinan, China. In Plos One, 2011
relationship between TPH2 SNPs and major depression
Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice.
Rao et al., Beijing, China. In Nature, 2011
A role for 5-HT was demonstrated by the phenotype of mice lacking tryptophan hydroxylase 2 (Tph2), which is required for the first step of 5-HT synthesis in the brain.
Brainstem serotonergic deficiency in sudden infant death syndrome.
Kinney et al., Boston, United States. In Jama, 2010
Compared with controls, SIDS was associated with lower 5-HT and TPH2 levels, consistent with a disorder of medullary 5-HT deficiency.
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