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Two pore segment channel 1

TPC-1, Calcium Channel, voltage-gated Ca channel
Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, RET, HAD, V1a, ACID
Papers using TPC-1 antibodies
ANTI-ADHESION evolves to a promising therapeutic concept in oncology
Bongarzone Italia et al., In Molecular Cancer, 2007
... TPC-1 lysates before and after drug treatments were stained for the C-terminal domain of the PARP protein, a marker of cell apoptosis, using an anti-PARP antibody (Cell Signaling Technology, Inc., Boston, MA, ...
Papers on TPC-1
The function of the two-pore channel TPC1 depends on dimerization of its carboxy-terminal helix.
Dietrich et al., Erlangen, Germany. In Cell Mol Life Sci, Feb 2016
In the model plant Arabidopsis, the vacuolar cation channel TPC1 is involved in propagation of calcium waves and in cation homeostasis.
Angiotensin System Blockade Combined With Calcium Channel Blockers Is Superior to Other Combinations in Cardiovascular Protection With Similar Blood Pressure Reduction: A Meta-Analysis in 20,451 Hypertensive Patients.
Xu et al., Shanghai, China. In J Clin Hypertens (greenwich), Feb 2016
UNASSIGNED: The authors aimed to investigate the superiority of angiotensin system blockade (angiotensin-converting enzyme [ACE] inhibitor/angiotensin receptor blocker [ARB]) plus a calcium channel blocker (CCB) (A+C) over other combination therapies in antihypertensive treatment.
Risks of Adverse Events Following Coprescription of Statins and Calcium Channel Blockers: A Nationwide Population-Based Study.
Fang et al., Chicago, United States. In Medicine (baltimore), Jan 2016
Inhibitors of CYP3A4 including some calcium channel blockers (CCBs) might increase statin blood concentration, owing to drug-drug interactions.
Effects of Concurrent Calcium Channel Blocker on Antiplatelet Efficacy of Clopidogrel Therapy: A Systematic Review.
Arora et al., North Chicago, United States. In Am J Ther, Jan 2016
Recently, research interest has grown in the area concerning an interaction of clopidogrel with calcium channel blockers.
Mutations of the Calcium Channel Gene cacophony Suppress Seizures in Drosophila.
Tanouye et al., Berkeley, United States. In Plos Genet, Jan 2016
Bang sensitive (BS) Drosophila mutants display characteristic seizure-like phenotypes resembling, in some aspects, those of human seizure disorders such as epilepsy.
The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca(2+) dynamics and insulin secretion.
Rutter et al., London, United Kingdom. In Cell Calcium, Jan 2016
Nicotinic acid adenine dinucleotide phosphate (NAADP), generated in β-cells in response to high glucose, is a potent mobiliser of these stores, and has been proposed to act through two pore channels (TPC1 and TPC2, murine gene names Tpcn1 and Tpcn2).
Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana.
Jiang et al., Dallas, United States. In Nature, Jan 2016
Here we present the crystal structure of a vacuolar two-pore channel from Arabidopsis thaliana, AtTPC1, which functions as a homodimer.
Reduced Risk of Parkinson's Disease in Users of Calcium Channel Blockers: A Meta-Analysis.
Bansal et al., India. In Int J Chronic Dis, 2014
To pool the data currently available to determine the association between calcium channel blockers (CCBs) and risk of Parkinson's disease (PD).
Calcium Channel Mutations in Cardiac Arrhythmia Syndromes.
Antzelevitch et al., Lancaster, United States. In Curr Mol Pharmacol, 2014
Activation of the L-type voltagegated calcium channel provides the calcium entry required for excitation-contraction coupling and contributes to the plateau phase of the cardiac action potential.
Calcium Channel Signaling Complexes with Receptors and Channels.
Zamponi, Calgary, Canada. In Curr Mol Pharmacol, 2014
On the other hand, voltage-gated calcium channel activity affects other types of ion channels such as voltage-and calcium-activated potassium channels.
Heterogeneity of Calcium Channel/cAMP-Dependent Transcriptional Activation.
Kobrinsky, Baltimore, United States. In Curr Mol Pharmacol, 2014
The major function of the voltage-gated calcium channels is to provide the Ca(2+) flux into the cell.
mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state.
Ren et al., Philadelphia, United States. In Cell, 2013
The channel is a complex formed by two-pore channels (TPC1 and TPC2), ion channels previously thought to be gated by nicotinic acid adenine dinucleotide phosphate (NAADP), and the mammalian target of rapamycin (mTOR).
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.
Xu et al., Ann Arbor, United States. In Cell, 2012
Mammalian two-pore channel proteins (TPC1, TPC2; TPCN1, TPCN2) encode ion channels in intracellular endosomes and lysosomes and were proposed to mediate endolysosomal calcium release triggered by the second messenger, nicotinic acid adenine dinucleotide phosphate (NAADP).
An N-terminal dileucine motif directs two-pore channels to the tonoplast of plant cells.
Dietrich et al., Erlangen, Germany. In Traffic, 2012
TPC1 contains a N-terminal dileucine motif (EDPLI) critical for vacuolar targeting
Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1.
Muallem et al., Bethesda, United States. In J Biol Chem, 2012
The concerted regulation of TPC1 activity by luminal Ca(2+) and by membrane potential thus provides a potential mechanism to explain NAADP-induced Ca(2+) oscillations.
Regulation of a proteinaceous elicitor-induced Ca2+ influx and production of phytoalexins by a putative voltage-gated cation channel, OsTPC1, in cultured rice cells.
Kuchitsu et al., Noda, Japan. In J Biol Chem, 2012
OsTPC1 plays a crucial role in TvX-induced Ca(2+) influx as a plasma membrane Ca(2+)-permeable channel consequently required for the regulation of phytoalexin biosynthesis
Cell-specific compartmentation of mineral nutrients is an essential mechanism for optimal plant productivity--another role for TPC1?
Conn et al., Adelaide, Australia. In Plant Signal Behav, 2011
TPC1 has a role in maintaining differential K and Ca storage across the leaf; it releases Ca2+ from epidermal and bundle sheath cell vacuoles to maintain low [Ca]vac.
A novel calcium binding site in the slow vacuolar cation channel TPC1 senses luminal calcium levels.
Hedrich et al., Würzburg, Germany. In Plant Cell, 2011
Results indicate that Glu-450 and Asp-454 of the slow vacuolar channel TPC1 are directly involved in Ca2+ binding, whereas Glu-456 and Glu-457 are probably involved in connecting the luminal Ca2+ binding site to the channel gate.
NAADP mobilizes calcium from acidic organelles through two-pore channels.
Zhu et al., Edinburgh, United Kingdom. In Nature, 2009
Here we show that two-pore channels (TPCs) comprise a family of NAADP receptors, with human TPC1 (also known as TPCN1) and chicken TPC3 (TPCN3) being expressed on endosomal membranes, and human TPC2 (TPCN2) on lysosomal membranes when expressed in HEK293 cells.
The vacuolar Ca2+-activated channel TPC1 regulates germination and stomatal movement.
Sanders et al., York, United Kingdom. In Nature, 2005
a tpc1 knockout mutant lacks functional slow vacuolar channel activity and is defective in both abscisic acid-induced repression of germination and in the response of stomata to extracellular calcium
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