GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
CREB regulated transcription coactivator 3
TORC3, CRTC3
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Top mentioned proteins:
CREB, mTORC1, mTORC2, MAML2, HAD
Papers on
TORC3
A nutrigenomics approach for the study of anti-aging interventions: olive oil phenols and the modulation of gene and microRNA expression profiles in mouse brain.
New
Florence, Italy. In Eur J Nutr, Jan 2016
Among those, we found genes previously associated with synaptic plasticity and with motor and cognitive behavior, such as Notch1, BMPs, NGFR, GLP1R and CRTC3.
Warthin-like Mucoepidermoid Carcinoma: A Combined Study of Fluorescence In Situ Hybridization and Whole-slide Imaging.
New
Nagoya, Japan. In Am J Surg Pathol, Nov 2015
The CRTC1-MAML2, but not CRTC3-MAML2 was detected in 5/15 mWT-like tumors.
Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2.
New
Odense, Denmark. In J Biol Chem, Nov 2015
Triggering of the cAMP pathway in hepatocytes stimulates the gluconeogenic program via the PKA-mediated phosphorylation of CREB and dephosphorylation of the cAMP-regulated CREB coactivators CRTC2 and CRTC3.
Molecular Basis for the Mechanism of Constitutive CBP/p300 Coactivator Recruitment by CRTC1-MAML2 and Its Implications in cAMP Signaling.
New
Evanston, United States. In Biochemistry, Oct 2015
Here we describe how both mechanisms could concurrently drive transcription of CREB targets in a subset of head and neck cancers featuring chromosomal translocations that fuse portions of CRTC1 and CRTC3 genes with that of the Mastermind-like transcriptional coactivator MAML2.
Oxytocin Regulates Stress-Induced Crf Gene Transcription through CREB-Regulated Transcription Coactivator 3.
New
Regensburg, Germany. In J Neurosci, Oct 2015
OT (1 nmol, i.c.v.) delayed the stress-induced increase of nuclear CRTC3 and Crf hnRNA levels in the paraventricular nucleus of male rats and mice, but did not affect either parameter in the absence of the stressor.
Thymic Mucoepidermoid Carcinoma: Report of a Case With CTRC1/3-MALM2 Molecular Studies.
New
Tampa, United States. In Int J Surg Pathol, Jun 2015
The recently described fusions, t(11;19)(q21;p13) CREB (cAMP response element-binding protein)-regulated transcription coactivator 1 and MAML2, mastermind-like gene 2 (CRTC1-MAML2) and t(11:15)(q21;q26) CRTC3-MAML2 characterize a considerable proportion of MEC examples arising from a variety of anatomical sites.
SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes.
New
In J Cell Sci, Mar 2015
Modulation of SIK2 in adipocytes resulted in altered phosphorylation of CREB-regulated transcription co-activator 2 (CRTC2), CRTC3 and class IIa histone deacetylase 4 (HDAC4).
The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases.
New
Dundee, United Kingdom. In Biochem J, Feb 2015
Consistent with the present finding, bosutinib and dasatinib induce the dephosphorylation of CREB-regulated transcription co-activator 3 (CRTC3) and its nuclear translocation where it induces a cAMP-response-element-binding protein (CREB)-dependent gene transcription programme including that of IL-10.
Neuroimmunological communication via CGRP promotes the development of a regulatory phenotype in TLR4-stimulated macrophages.
München, Germany. In Eur J Immunol, 2014
The stimulatory effect of CGRP on IL-10 production required activation of protein kinase A and was linked to prolonged phosphorylation of CREB and sustained nuclear accumulation of CRTC2 and CRTC3 (where CRTC is CREB-regulated transcriptional cofactor).
Requirement of CRTC1 coactivator for hepatitis B virus transcription.
Hong Kong, Hong Kong. In Nucleic Acids Res, 2014
Ectopic expression of CRTC1 or its homolog CRTC2 or CRTC3 in hepatoma cells stimulated the activity of the preS2/S promoter of HBV, whereas overexpression of a dominant inactive form of CRTC1 inhibited HBV transcription.
CRTC3 polymorphisms were associated with the plasma level of total cholesterol and the risks of overweight and hypertriglyceridemia in a Chinese Han population.
Guangzhou, China. In Mol Biol Rep, 2014
CREB-regulated transcription coactivator 3 (CRTC3) was a recently identified protein which played an important role in glucose and lipid metabolism.
Analysis of structural diversity in wolf-like canids reveals post-domestication variants.
Barcelona, Spain. In Bmc Genomics, 2013
Among the CNV regions that showed the largest differentiation between dogs and wild canids we found 12 genes, nine of which are related to two known functions associated with dog domestication; growth (PDE4D, CRTC3 and NEB) and neurological function (PDE4D, EML5, ZNF500, SLC6A11, ELAVL2, RGS7 and CTSB).
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands.
Gdańsk, Poland. In Am J Surg Pathol, 2013
The recurrent translocations t(11;19) and t(11;15) resulting in CRTC1-MAML2 or CRTC3-MAML2 fusion oncogenes, respectively, are identified in a large proportion of mucoepidermoid carcinomas (MECs) of the salivary gland and have impact on prognosis.
CREB-regulated transcription co-activator family stimulates promoter II-driven aromatase expression in preadipocytes.
Melbourne, Australia. In Horm Cancer, 2013
Under basal conditions, CRTC1 expression was the lowest, whereas CRTC3 transcripts were present at higher levels.
Impact of CRTC1/3-MAML2 fusions on histological classification and prognosis of mucoepidermoid carcinoma.
GeneRIF
Nagoya, Japan. In Histopathology, 2011
mucoepidermoid carcinoma of the salivary glands positive for CRTC1-MAML2 or CRTC3-MAML2 fusion formed a favourable tumour subset that was distinct from fusion-negative cases
Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells.
GeneRIF
Los Angeles, United States. In J Biol Chem, 2011
CRTC3 plays a selective role in mitochondrial biogenesis in response to rotenone
CRTC3 links catecholamine signalling to energy balance.
Impact
GeneRIF
Los Angeles, United States. In Nature, 2011
As a common human CRTC3 variant with increased transcriptional activity is associated with adiposity in two distinct Mexican-American cohorts, results suggest that adipocyte CRTC3 may play a role in the development of obesity in humans
Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma.
GeneRIF
Nagoya, Japan. In Mod Pathol, 2009
Mucoepidermoid carcinomas possessing CRTC3-MAML2 fusion may be associated with favorable clinicopathological features and patients may be younger than those with CRTC1-MAML2 fusion or those with no detectable gene fusion.
A new type of MAML2 fusion in mucoepidermoid carcinoma.
GeneRIF
Bremen, Germany. In Genes Chromosomes Cancer, 2008
study reports for the first time a CRTC3-MAML2 fusion gene in a mucoepidermoid carcinoma, as determined by RT-PCR and sequencing.
