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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Toll interacting protein

Tollip, Toll-interacting protein
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: TLR4, IRAK, TLR2, MyD88, IL-1beta
Papers on Tollip
Salmonella Virulence Factor SsrAB Regulated Factor Modulates Inflammatory Responses by Enhancing the Activation of NF-κB Signaling Pathway.
Liu et al., Wuhan, China. In J Immunol, Feb 2016
SrfA was secreted into the cytoplasm during S. Typhimurium infection and disassociated IL-1R-associated kinase-1 (IRAK-1) from the IRAK-1-Toll interacting protein (Tollip) complex by interacting with Tollip.
TOLLIP, MUC5B, and the Response to N-Acetylcysteine among Individuals with Idiopathic Pulmonary Fibrosis.
IPFnet Investigators et al., Denver, United States. In Am J Respir Crit Care Med, Jan 2016
The genes TOLLIP and MUC5B play important roles in lung host defense, which is an immune process influenced by oxidative signaling.
Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk.
Lung Transplant Outcomes Group et al., Nashville, United States. In Am J Transplant, Jan 2016
rs3168046 (Toll interacting protein [TOLLIP]) was significantly associated with PGD (p = 0.006).
Function analysis of fish Tollip gene in response to virus infection.
Qin et al., Guangzhou, China. In Fish Shellfish Immunol, Dec 2015
Toll-interacting protein (Tollip) is one of the important regulatory proteins of Toll-like receptor (TLR) signaling pathways.
Genetic Variation in Toll-Interacting Protein Is Associated With Leprosy Susceptibility and Cutaneous Expression of Interleukin 1 Receptor Antagonist.
Hawn et al., Kathmandu, Nepal. In J Infect Dis, Dec 2015
Toll-interacting protein (TOLLIP) regulates Toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) signaling against mycobacteria.
Differential expression of key regulators of Toll-like Receptors in Ulcerative Colitis and Crohn's disease: A role for Tollip and PPARγ?
Brint et al., Cork, Ireland. In Clin Exp Immunol, Nov 2015
In contrast, expression of both PPARγ and TOLLIP was decreased in both active and inactive UC and CD and at both mRNA and protein levels.
Time to Fold: Tom1 Uses New Tricks to Regulate Lipid Binding of Tollip.
Stahelin, South Bend, United States. In Structure, Nov 2015
Structural and functional studies demonstrate that Tom1 interactions with the cargo sorting protein Tollip induce the partially unfolded Tom1-binding domain of Tollip to fold.
Identification, characterization and expression profiling of the Tollip gene in Yesso scallop (Patinopecten yessoensis).
Bao et al., Taiwan. In Genes Genet Syst, 2014
Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated innate immune responses.
Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family.
Jentsch et al., Martinsried, Germany. In Cell, 2014
Here, we identify by a screen in yeast a new class of ubiquitin-Atg8 adaptors termed CUET proteins, comprising the ubiquitin-binding CUE-domain protein Cue5 from yeast and its human homolog Tollip.
Role of innate immunity in primary graft dysfunction after lung transplantation.
Wigfield et al., Chicago, United States. In Curr Opin Organ Transplant, 2013
Long pentraxin-3 and Toll-like receptors, as well as inflammasomes and Toll-interacting protein, are associated with the development of PGD after lung transplantation.
Beyond the diagnosis of idiopathic pulmonary fibrosis; the growing role of systems biology and stratified medicine.
Maher, London, United Kingdom. In Curr Opin Pulm Med, 2013
RECENT FINDINGS: Large-scale genome-wide association studies have highlighted polymorphisms in genes involved in epithelial integrity and host defense including MUC5B and TOLLIP.
[Negative regulation of Toll-like receptor signalling].
Choroszyńska et al., Lublin, Poland. In Postepy Hig Med Dosw (online), 2012
They include soluble receptors (sTLR), transmembrane proteins (ST2, SIGIRR, RP105, TRAIL-R) and intracellular inhibitors (SOCS-1, SOCS-3, sMyD88, TOLLIP, IRAK-M, SARM, A20, β-arrestin, CYLD, SHP).
Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis.
Hawn et al., Seattle, United States. In J Immunol, 2012
These data demonstrate that TOLLIP has an anti-inflammatory effect on TLR2 and TLR4 signaling in humans
Molecular mechanisms responsible for the selective and low-grade induction of proinflammatory mediators in murine macrophages by lipopolysaccharide.
Li et al., Blacksburg, United States. In J Immunol, 2012
Low-dose lipopolysaccharide utilizes Tollip and interleukin (IL)-1 receptor-associated kinase (IRAK)-1 to induce mitochondrial reactive oxygen species to subsequently induce activating transcription factor (ATF)2 in chronic low-grade inflammatory disease.
β-Thalassemia trait association with autoimmune diseases: β-globin locus proximity to the immunity genes or role of hemorphins?
Deniz et al., İstanbul, Turkey. In Immunopharmacol Immunotoxicol, 2012
These associations make sense when considering that the hemoglobin β-chain locus at 11p15.5 resides in close proximity to eight genes with profound roles in immune regulation: STIM1, CD151, TC21/RRAS2, SIGIRR/TOLL/IL1R8, pp52/LSP1 (lymphocyte specific protein), TRIM21, toll interacting protein (TOLLIP) and SLEN3.
Tollip: a multitasking protein in innate immunity and protein trafficking.
Capelluto, Blacksburg, United States. In Microbes Infect, 2012
The Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated innate immune responses.
Expression and localization of TLR4 and its negative regulator Tollip in the placenta of early-onset and late-onset preeclampsia.
Yang et al., Beijing, China. In Hypertens Pregnancy, 2011
located in the cytoplasm of cytotrophoblasts in the first-trimester placental tissues
Transcription of the Tollip gene is elevated in intestinal epithelial cells through impaired O-GlcNAcylation-dependent nuclear translocation of the negative regulator Elf-1.
Kaminogawa et al., Fujisawa, Japan. In Biochem Biophys Res Commun, 2011
the results indicate that insufficient O-GlcNAc modification prevents Elf-1-mediated transcriptional repression and thereby upregulates Tollip gene expression in intestinal epithelial cells.
The C2 domain of Tollip, a Toll-like receptor signalling regulator, exhibits broad preference for phosphoinositides.
Capelluto et al., Blacksburg, United States. In Biochem J, 2011
These findings suggest that basic residues of the C2 domain mediate membrane targeting of Tollip by interaction with phosphoinositides, which contribute to the observed partition of the protein in different subcellular compartments.
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
Volpe et al., Biel, Switzerland. In Nat Cell Biol, 2000
Binding of IL-1 to its receptor results in rapid assembly of a membrane-proximal signalling complex that consists of two different receptor chains (IL-1Rs), IL-1RI and IL-1RAcP, the adaptor protein MyD88, the serine/threonine kinase IRAK and a new protein, which we have named Tollip.
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