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Toll-like receptor 1

Toll-like receptor, TLR1
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TLR4, TLR2, V1a, CAN, Interleukin-6
Papers using Toll-like receptor antibodies
NF-κB-mediated induction of mdr1b expression by insulin in rat hepatoma cells
Masereeuw Rosalinde et al., In Journal of Biomedicine and Biotechnology, 1996
... (Eugene, OR), bisindolylmaleimide (BIM, Bruschwig chemie, Amsterdam, the Netherlands), H398 from Alexis (Lausen, Switzerland), antihuman Toll-like receptor (TLR)4 CD284/MD complex from Biolegend (San Diego, USA), and ...
Papers on Toll-like receptor
Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography.
Lizasoain et al., Madrid, Spain. In J Cereb Blood Flow Metab, Feb 2016
UNASSIGNED: The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques.
Differential activation of innate immune pathways by distinct islet amyloid polypeptide (IAPP) aggregates.
Verchere et al., Canada. In J Biol Chem, Feb 2016
Soluble IAPP species produced early during IAPP aggregation provided a Toll-like-receptor-2- (TLR2-) dependent stimulus for NF-κB activation in HEK 293 cells and bone marrow-derived macrophages (BMDMs).
Potential biomarker for checkpoint blockade immunotherapy and treatment strategy.
Wu et al., Guangzhou, China. In Tumour Biol, Feb 2016
PD-L1 can be induced by interferon-gamma (IFN-γ), hypoxia, or toll-like receptor (TLR)-mediated pathways that confer adaptive immune resistance, or upregulated by oncogenic signals leading to constitutive expression and resulting in intrinsic immune resistance.
Inflammation and immune regulation as potential drug targets in antidepressant treatment.
Lichtblau et al., Leipzig, Germany. In Curr Neuropharmacol, Feb 2016
A perspective is also provided on possible future immune targets for antidepressant therapy, such as toll-like receptor-inhibitors, glycogen synthase kinase-3 inhibitors, oleanolic acid analogs and minocycline.
Metabolic derivatives of alcohol and the molecular culprits of fibro-hepatocarcinogenesis: Allies or enemies?
Yang et al., Hefei, China. In World J Gastroenterol, Feb 2016
We also brought to sharp focus, the complex and integrative role of transforming growth factor beta/small mothers against decapentaplegic/plasminogen activator inhibitor-1 and the mitogen activated protein kinase signaling nexus as well as their cross-signaling with toll-like receptor-mediated gut-dependent signaling pathways implicated in ALD and fibro-hepatocarcinogenesis.
Human Milk Components Modulate Toll-Like Receptor-Mediated Inflammation.
Newburg et al., Boston, United States. In Adv Nutr, Jan 2016
Toll-like receptor (TLR) signaling is central to innate immunity.
Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens.
Amigorena et al., Paris, France. In Immunity, Jan 2016
The initiation of cytotoxic immune responses by dendritic cells (DCs) requires the presentation of antigenic peptides derived from phagocytosed microbes and infected or dead cells to CD8(+) T cells, a process called cross-presentation.
Serum Amyloid A Induces Toll-Like Receptor 2-Dependent Inflammatory Cytokine Expression and Atrophy in C2C12 Skeletal Muscle Myotubes.
Hansen et al., Melbourne, Australia. In Plos One, Dec 2015
BACKGROUND: Skeletal muscle wasting is an important comorbidity of Chronic Obstructive Pulmonary Disease (COPD) and is strongly correlated with morbidity and mortality.
A Human Anti-Toll Like Receptor 4 Fab Fragment Inhibits Lipopolysaccharide-Induced Pro-Inflammatory Cytokines Production in Macrophages.
Zhu et al., Nanjing, China. In Plos One, Dec 2015
The results of clinical and experimental studies suggest that endotoxin/toll-like receptor 4 (TLR4)-mediated proinflammatory and profibrotic signaling activation is critical in the development of hepatic fibrosis.
Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria.
Kagan et al., Boston, United States. In Immunity, Dec 2015
Upon detection of bacterial lipopolysaccharides (LPS), CD14 induces an inflammatory endocytosis pathway that delivers Toll-like receptor 4 (TLR4) to endosomes.
Polymorphisms of Toll-Like Receptor 4 as a Risk Factor for Periodontitis: Meta-Analysis.
Ziętek et al., Wrocław, Poland. In Adv Clin Exp Med, Nov 2015
BACKGROUND: Toll-like receptors play an important role in the recognition of periopathogens.
Current Treatment Options for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
Cohen et al., San Diego, United States. In J Clin Oncol, Nov 2015
Immunotherapy represents an attractive treatment strategy for R/M HNSCC, with promising preliminary data from studies involving immune checkpoint blockade and toll-like receptor agonists.
dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration.
Garza et al., Baltimore, United States. In Cell Stem Cell, Sep 2015
Here, we show that dsRNA, which is released from damaged skin, activates Toll-Like Receptor 3 (TLR3) and its downstream effectors IL-6 and STAT3 to promote hair follicle regeneration.
Role of interleukin 33/ST2 axis in the immune-mediated pathogenesis of age-related macular degeneration.
Dick et al., Bristol, United Kingdom. In Lancet, Mar 2015
We tested the hypothesis that toll-like receptor activation of retinal pigment epithelium and cellular metabolic switch upregulate interleukin 33, which acts through its receptor ST2 to activate both choroidal stromal fibroblasts and mast cells.
Effect of sinomenine on the expression of rheumatoid arthritis fibroblast-like synoviocytes MyD88 and TRAF6.
Chen et al., Changchun, China. In Genet Mol Res, 2014
The effect of sinomenine (SIN) on the toll-like receptor (TLR) signal transduction pathway as well as the expression of myeloid differentiation factor 88 (MyD88) and tumor necrosis factor (TNF) receptor-associated factor-6 (TRAF6) was investigated.
The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-κB-related signaling pathways.
Wei et al., Beijing, China. In Biomaterials, 2012
Graphene significantly stimulates the secretion of cytokines/chemokines via TLR- and NF-kappaB-related signaling pathways
Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation.
Turpeinen et al., Helsinki, Finland. In Scand J Immunol, 2012
The results showed that the genetic markers in TLR1, TLR4, TLR5 TLR6, and TLR10 were associated with the occurrence of acute Graft-versus-host disease following hematopoietic stem cell transplantation
Polymorphisms in toll-like receptor 1 and 9 genes and their association with tuberculosis susceptibility in Chinese Holstein cattle.
Yang et al., Wuhan, China. In Vet Immunol Immunopathol, 2012
variants in the TLR1 gene are associated with susceptibility to bovine tuberculosis, whereas no significant association can be inferred from the polymorphisms in the TLR9 gene
Cell surface trafficking of TLR1 is differentially regulated by the chaperones PRAT4A and PRAT4B.
Tapping et al., Urbana, United States. In J Biol Chem, 2012
a mechanism for the differential trafficking of TLR1 I602S variants, and highlight the distinct roles for PRAT4A and PRAT4B in the regulation of TLR1 surface expression.
Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.
Bochud et al., Lausanne, Switzerland. In J Infect Dis, 2012
Innate immune detection of Aspergillus fumigatus is mediated by TLR4 and TLR2 together with TLR1 or TLR6 in mice.
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