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Ecto-NOX disulfide-thiol exchanger 2

The protein encoded by this gene is a growth-related cell surface protein. It was identifed because it reacts with the monoclonal antibody KI in cells, such as the ovarian carcinoma line OVCAR-3, also expressing the CAKI surface glycoprotein. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The two activities alternate with a period length of about 24 minutes. The encoded protein also displays prion-like properties. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Phosphogluconate Dehydrogenase, ACID, HAD, Serum albumin, CLOCK
Papers on tNOX
Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.
Chueh et al., Moscow, Russia. In J Med Chem, Jan 2016
Compounds 11-14 utilized multiple mechanisms of cytotoxicity including inhibition of Top1/Top2-mediated DNA relaxation, reduced NAD(+)/NADH ratio through tNOX inhibition, suppression of a NAD(+)-dependent sirtuin 1 (SIRT1) deacetylase activity, and activation of caspase-mediated apoptosis.
Sirtuin 1 (SIRT1) Deacetylase Activity and NAD⁺/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death.
Chueh et al., T'ai-chung-shih, Taiwan. In J Agric Food Chem, Sep 2015
In contrast, capsaicin decreased the intracellular NAD(+)/NADH ratio, possibly through inhibition of tumor-associated NADH oxidase (tNOX), and diminished SIRT1 expression leading to enhanced p53 acetylation and apoptosis.
TGF-β1 suppression of microRNA-450b-5p expression: a novel mechanism for blocking myogenic differentiation of rhabdomyosarcoma.
Wang et al., Suzhou, China. In Oncogene, 2014
Among these candidates, only the expression of ecto-NOX disulfide-thiol exchanger 2 (ENOX2) and paired box 9 (PAX9) was augmented by miR-450b-5p knockdown examined by western blot; the engineered inhibition antagonized TGF-β1-mediated differentiation inhibition.
ENOX2 target for the anticancer isoflavone ME-143.
Morré et al., West Lafayette, United States. In Oncol Res, 2013
ME-143 (NV-143), a synthetic isoflavone under clinical evaluation for efficacy in the management of ovarian and other forms of human cancer, blocked the activity of a cancer-specific and growth-related cell surface ECTO-NOX protein with both oxidative (hydroquinone) and protein disulfide-thiol interchange activity designated ENOX2 (tNOX) and inhibited the growth of cultured cancer cells with EC50s in the range of 20-50 nM.
Cancer prevention trial of a synergistic mixture of green tea concentrate plus Capsicum (CAPSOL-T) in a random population of subjects ages 40-84.
Morré et al., West Lafayette, United States. In Clin Proteomics, 2013
In this study, we evaluated an early cancer detection strategy of cancer presence based on serum levels of the cancer-specific transcript variants of ENOX2 in serum coupled with an ENOX2-targeted nutraceutical preparation of green tea concentrate plus Capsicum (Capsol-T®) as a strategy of Curative Prevention® involving early detection coupled with early intervention in early stage cancer when in its most susceptible and manageable stages.
Chemotherapeutic agents enhance cell migration and epithelial-to-mesenchymal transition through transient up-regulation of tNOX (ENOX2) protein.
Chueh et al., Zhongxing, China. In Biochim Biophys Acta, 2012
BACKGROUND: Tumor-associated NADH oxidase (tNOX; ENOX2) is a growth-related protein expressed in transformed cells.
X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma.
Gershwin et al., Davis, United States. In Clin Exp Immunol, 2012
Identified genes include transcription factors (ARX, HSFX1, ZBED1, ZNF41) and surface antigens (IL1RAPL2, PGRMC1), and pathway analysis suggests their involvement in cell proliferation (PGK1, SMS, UTP14A, SSR4), apoptosis (MTM1), inflammation (ARAF) and oxidative stress (ENOX2).
Phosphorylation of serine-504 of tNOX (ENOX2) modulates cell proliferation and migration in cancer cells.
Chueh et al., T'ai-chung-shih, Taiwan. In Exp Cell Res, 2012
The results suggest that phosphorylation of serine-504 by PKCdelta modulates the biological function of tNOX.
Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo.
Chueh et al., Zhongxing, China. In J Agric Food Chem, 2012
Here, we made the unexpected discovery that treatment with low concentrations of capsaicin up-regulates tNOX (tumor-associated NADH oxidase) expression in HCT116 human colon carcinoma cells in association with enhanced cell proliferation and migration, as evidenced by down-regulation of epithelial markers and up-regulation of mesenchymal markers.
Down-regulation of tumor-associated NADH oxidase, tNOX (ENOX2), enhances capsaicin-induced inhibition of gastric cancer cell growth.
Chueh et al., Zhongxing, China. In Cell Biochem Biophys, 2011
Capsaicin-induced apoptosis in SNU-1 cells was associated with down-regulation of tumor-associated NADH oxidase (tNOX) mRNA and protein.
hnRNP F directs formation of an exon 4 minus variant of tumor-associated NADH oxidase (ENOX2).
Morré et al., West Lafayette, United States. In Mol Cell Biochem, 2011
this result suggests that hnRNP F directs formation of the exon 4 minus variant of ENOX2
Metabolite modulation of HeLa cell response to ENOX2 inhibitors EGCG and phenoxodiol.
Morré et al., West Lafayette, United States. In Biochim Biophys Acta, 2011
increased NADH levels resulting from ENOX2 inhibition result in decreased prosurvival sphingosine-1-phosphate and increased proapoptotic ceramide, both of which may be important to initiation of the ENOX2 inhibitor-induced apoptotic cascade.
Essential role of copper in the activity and regular periodicity of a recombinant, tumor-associated, cell surface, growth-related and time-keeping hydroquinone (NADH) oxidase with protein disulfide-thiol interchange activity (ENOX2).
Morré et al., West Lafayette, United States. In J Bioenerg Biomembr, 2010
ENOX2 is a dimeric protein containing 4 coppers/dimer capable of carrying out concerted four electron transfers from NADH or ubiquinol to molecular oxygen as required to form water.
Omega-3 but not omega-6 unsaturated fatty acids inhibit the cancer-specific ENOX2 of the HeLa cell surface with no effect on the constitutive ENOX1.
Brightmore et al., West Lafayette, United States. In J Diet Suppl, 2010
In experiments with surface NOX proteins released from HeLa cells, spectrophotometric measurements of the oxidation of NADH revealed inhibition of the cancer-specific ENOX2 activity by CLA and the omega-3 fatty acids, eicosapentaenoic, docosahexaenoic, and α-linolenic acids.
arNOX: generator of reactive oxygen species in the skin and sera of aging individuals subject to external modulation.
Morré et al., West Lafayette, United States. In Rejuvenation Res, 2010
arNOX activity correlates with age and reaches a maximum at about age 65 in males and 55 in females.
Spotlight on tNOX: a tumor-selective target for cancer therapies.
Bozzo et al., In Drug News Perspect, 2006
Tumor-associated NOX (tNOX) is a novel cell surface ECTO-NOX protein that represents a promising target for selective antitumor therapy.
Cell surface NADH oxidases (ECTO-NOX proteins) with roles in cancer, cellular time-keeping, growth, aging and neurodegenerative diseases.
Morré et al., West Lafayette, United States. In Free Radic Res, 2003
A tumor-associated ECTO-NOX (tNOX) is cancer-specific and drug-responsive.
Cell membrane redox systems and transformation.
Chueh, West Lafayette, United States. In Antioxid Redox Signal, 1999
In addition, information on a unique tumor-associated nicotinamide adenine dinucleotide (NADH) oxidase (tNOX) protein is reviewed.
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