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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Thioredoxin-related transmembrane protein 1

TXNDC1 is a thioredoxin (TXN; see MIM 187700)-related protein with disulfide reductase activity (Matsuo et al., 2001 [PubMed 11152479]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: HAD, ACID, CAN, V1a, Thioredoxin
Papers on TMX
The Membrane Topology of Vitamin K Epoxide Reductase is conserved between Human Isoforms and the Bacterial Enzyme.
Bulleid et al., Glasgow, United Kingdom. In Biochem J, Feb 2016
We used a redox sensitive GFP fused to the N- or C- terminus to show that these regions face the cytosol, and introduction of glycosylation sites along with mixed disulfide formation with thioredoxin like transmembrane protein (TMX) to demonstrate ER localisation of the major loop.
Tamoxifen disrupts the reproductive process in gilthead seabream males and modulates the effects promoted by 17α-ethynylestradiol.
García-Ayala et al., Murcia, Spain. In Comp Biochem Physiol C Toxicol Pharmacol, Jan 2016
In the present study, adult male specimens of the marine hermaphrodite teleost gilthead (Sparus aurata L.) were fed a diet containing tamoxifen (Tmx), an estrogen receptor ligand used in cancer therapy, alone or combined with EE2, for 25days and then fed a commercial diet for a further 25days (recovery period).
Injection of insect membrane in Xenopus oocyte: An original method for the pharmacological characterization of neonicotinoid insecticides.
Mattei et al., Angers, France. In J Pharmacol Toxicol Methods, Jan 2016
We compared the effect of nicotine (NIC) with clothianidin (CLO) and we assessed the effect of thiamethoxam (TMX).
Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells.
Ann et al., Duarte, United States. In Oncotarget, Jan 2016
To test this hypothesis, we treated breast cancer MDA-MB-231 cells with tamoxifen (TMX), which induces autophagy through an estrogen receptor-independent pathway.
Tamoxifen persistently disrupts the humoral adaptive immune response of gilthead seabream (Sparus aurata L.).
García-Ayala et al., Murcia, Spain. In Dev Comp Immunol, Dec 2015
Tamoxifen (Tmx) is a selective estrogen-receptor modulator used in hormone replacement therapy, the effects of which are unknown in fish immunity.
Memory enhancement by tamoxifen on amyloidosis mouse model.
Mishra et al., Rānchī, India. In Horm Behav, Nov 2015
UNASSIGNED: Tamoxifen (TMX) is a selective estrogen receptor modulator (SERM) used in the treatment of breast cancer.
Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancer.
Chen et al., Birmingham, United States. In Oncotarget, Oct 2015
We investigated the effects of calmodulin(CaM) antagonists, trifluoperazine(TFP) and tamoxifen(TMX), on TRA-8-induced apoptosis and tumorigenesis of TRA-8-resistant pancreatic cancer cells, and underlying mechanisms.
Controlling the Morphology of Organic Crystals with Filamentous Bacteriophages.
Furst et al., Newark, United States. In Acs Appl Mater Interfaces, Aug 2015
The preparation of thiamethoxam (TMX) organic crystals with high morphological uniformity was achieved by controlled aggregation-driven crystallization of primitive TMX crystals and phage using the filamentous M13 bacteriophage.
The Effects of Adjuvant Endocrine Treatment on Serum Leptin, Serum Adiponectin and Body Composition in Patients with Breast Cancer: The Izmir Oncology Group (IZOG) Study.
Tarhan et al., In Chemotherapy, 2014
BACKGROUND: A limited number of studies have been conducted on the effects of hormonal therapy with tamoxifen (TMX) or aromatase inhibitors (AIs) on plasma levels of leptin and adiponectin, as well as body composition in breast cancer (BC) patients.
Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model.
Chang et al., Pittsburgh, United States. In Plos One, 2014
Standard tamoxifen (TMX) administration to adult UbcCreERT2; ROSAsT mice, in which Cre is ubiquitously expressed, resulted in MCV sT expression in multiple organs that was uniformly lethal within 5 days.
Reductive activation of type 2 ribosome-inactivating proteins is promoted by transmembrane thioredoxin-related protein.
Colombatti et al., Verona, Italy. In J Biol Chem, 2012
the silencing of TMX in the prostatic cell line DU145 reduced the sensitivity of the cells to ricin intoxication further confirming a role for this enzyme in intracellular ricin activation.
Palmitoylated TMX and calnexin target to the mitochondria-associated membrane.
Simmen et al., Edmonton, Canada. In Embo J, 2012
TMX1 is enriched on the mitochondria-associated membrane. Targeting TMX to the MAM requires palmitoylation of two membrane-proximal cytosolic cysteines.
Physical and functional interaction of transmembrane thioredoxin-related protein with major histocompatibility complex class I heavy chain: redox-based protein quality control and its potential relevance to immune responses.
Yodoi et al., Kyoto, Japan. In Mol Biol Cell, 2009
These results suggest a specific role for transmembrane thioredoxin-related protein TMX and its mechanism of action in redox-based ER quality control.
Febuxostat: a selective xanthine-oxidase/xanthine-dehydrogenase inhibitor for the management of hyperuricemia in adults with gout.
Fravel et al., Iowa City, United States. In Clin Ther, 2009
Key search terms included febuxostat, hyperuricemia, gout, TMX-67, and TEI-6720.
Febuxostat: a novel non-purine selective inhibitor of xanthine oxidase for the treatment of hyperuricemia in gout.
Yu, Taiwan. In Recent Pat Inflamm Allergy Drug Discov, 2007
Key search terms were febuxostat, TMX-67, and TEI-6720.
Febuxostat: a selective xanthine oxidase inhibitor for the treatment of hyperuricemia and gout.
Bruce, Albany, United States. In Ann Pharmacother, 2006
Key search terms were febuxostat, TMX-67, TEI-6720, hyperuricemia, and gout.
The thioredoxin system in retroviral infection and apoptosis.
Yodoi et al., Kyoto, Japan. In Cell Death Differ, 2005
Thioredoxin 2 is a critical regulator of cytochrome c release and mitochondrial apoptosis; transmembrane thioredoxin-related molecule (TMX) has a protective role in endoplasmic reticulum (ER) stress-induced apoptosis.
Estrogen, anti-estrogen, and gender: differences in methamphetamine neurotoxicity.
McDermott et al., United States. In Ann N Y Acad Sci, 2002
In Part 1 of this report, we review data on the effects of estrogen (E), the anti-E tamoxifen (TMX), and testosterone (T) on methamphetamine (METH)-induced neurotoxicity in female and male CD-1 mice.
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