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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Anoctamin 2

TMEM16B, ANO2, C12orf3
ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011] (from NCBI)
Top mentioned proteins: ACID, CACC, CAN, TMEM16C, OUT
Papers on TMEM16B
Expression of calcium-activated chloride channels Ano1 and Ano2 in mouse taste cells.
Kolesnikov et al., Moscow, Russia. In Pflugers Arch, Feb 2016
Because Ano1 and Ano2 encode channel proteins that form CaCCs in a variety of cells, we analyzed their expression in mouse taste cells.
Covalency hinders AnO2(H2O)(+) → AnO(OH)2(+) isomerisation (An = Pa-Pu).
Kaltsoyannis, Manchester, United Kingdom. In Dalton Trans, Feb 2016
UNASSIGNED: The enthalpies of the reactions AnO2(+) → AnO(+) + O and AnO2(+) + H2O → AnO2(H2O)(+), and those of the isomerisation of the latter to AnO(OH)2(+), have been calculated for An = Pa-Pu.
Modulating Ca(2+) signals: a common theme for TMEM16, Ist2, and TMC.
Schreiber et al., Regensburg, Germany. In Pflugers Arch, Jan 2016
Compromised anoctamin function is causing a wide range of diseases, such as hearing loss (ANO2), bleeding disorder (ANO6), ataxia and dystonia (ANO3, 10), persistent borrelia and mycobacteria infection (ANO10), skeletal syndromes like gnathodiaphyseal dysplasia and limb girdle muscle dystrophy (ANO5), and cancer (ANO1, 6, 7).
Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B.
Arreola et al., San Luis Potosí, Mexico. In J Physiol, Jan 2016
KEY POINTS: Calcium-activated chloride channels TMEM16A and TMEM16B support important physiological processes such as fast block of polyspermy, fluid secretion, control of blood pressure and sensory transduction.
Reliable Potential Energy Surfaces for the Reactions of H2O with ThO2, PaO2(+), UO2(2+), and UO2(.).
Dixon et al., Tuscaloosa, United States. In J Phys Chem A, Dec 2015
The reactions proceed by the formation of an initial Lewis acid-base adduct (H2O)AnO2(0/+/2+) followed by a proton transfer to generate the dihydroxide AnO(OH)2(0/+/2+).
Protons inhibit anoctamin 1 by competing with calcium.
Oh et al., Seoul, South Korea. In Cell Calcium, Nov 2015
Here, we demonstrate that Ca(2+)-induced activation of ANO1 and its homolog ANO2 are strongly inhibited by intracellular acid.
Precise equilibrium structure determination of hydrazoic acid (HN3) by millimeter-wave spectroscopy.
McMahon et al., Madison, United States. In J Chem Phys, Oct 2015
The present Re geometric parameters of HN3 are determined with exceptionally high accuracy, as a consequence of the large number of isotopologues measured experimentally and the sophisticated (coupled-cluster theoretical treatment (CCSD(T))/ANO2) of the vibration-rotation interactions.
Oxidation of Actinyl(V) Complexes by the Addition of Nitrogen Dioxide Is Revealed via the Replacement of Acetate by Nitrite.
Gibson et al., Berkeley, United States. In Inorg Chem, Oct 2015
The gas-phase complexes AnO2(CH3CO2)2(-) are actinyl(V) cores, An(V)O2(+) (An = U, Np, Pu), coordinated by two acetate anion ligands.
Elucidating Protactinium Hydrolysis: The Relative Stabilities of PaO2(H2O)(+) and PaO(OH)2(+).
Gibson et al., Berkeley, United States. In Inorg Chem, Sep 2015
The gas-phase results are consistent with the spontaneous hydrolysis of PaO2(+) in aqueous solution, this in contrast to later AnO2(+) (An = U, Np, Pu), which forms stable hydrates in both solution and gas phase.
TMEM16 proteins: unknown structure and confusing functions.
Accardi et al., New York City, United States. In J Mol Biol, Feb 2015
The first two family members to be functionally characterized, TMEM16A (ANO1) and TMEM16B (ANO2), form Ca(2+)-activated Cl(-) channels and are important for transepithelial ion transport, olfaction, phototransduction, smooth muscle contraction, nociception, cell proliferation and control of neuronal excitability.
Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex.
Möhrlen et al., Heidelberg, Germany. In Plos One, 2014
We identified two anoctamin channel proteins, ANO1 and ANO2, in the cerebellar cortex.
Structure and function of TMEM16 proteins (anoctamins).
Galietta et al., In Physiol Rev, 2014
The first two members of the family, TMEM16A (anoctamin-1, ANO1) and TMEM16B (anoctamin-2, ANO2), function as Ca2+-activated Cl- channels (CaCCs), a type of ion channel that plays important functions such as transepithelial ion transport, smooth muscle contraction, olfaction, phototransduction, nociception, and control of neuronal excitability.
Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons.
Jan et al., San Francisco, United States. In Neuron, 2012
TMEM16B calcium-activated chloride channels control action potential waveform and synaptic efficacy in hippocampal neurons.
Expression patterns of anoctamin 1 and anoctamin 2 chloride channels in the mammalian nose.
Möhrlen et al., Heidelberg, Germany. In Cell Tissue Res, 2012
the main functional features of ANO 1 and ANO 2 chloride channels in the nose and suggest their significance for nasal physiology.
Anoctamin 2/TMEM16B: a calcium-activated chloride channel in olfactory transduction.
Menini et al., Trieste, Italy. In Exp Physiol, 2012
In this review, we summarize evidence supporting the hypothesis that anoctamin 2/TMEM16B is the main, or perhaps the only, constituent of the Ca(2+)-activated Cl(-) channels involved in olfactory transduction.
Ca2+-activated Cl- channels.
Galietta et al., Genova, Italy. In Compr Physiol, 2011
Recent studies indicate that TMEM16A (transmembrane protein 16 A or anoctamin 1) and TMEM16B (transmembrane protein 16 B or anoctamin 2) are CaCC-forming proteins.
Ca2+-activated Cl− currents are dispensable for olfaction.
Jentsch et al., Berlin, Germany. In Nat Neurosci, 2011
Data show that Ano2 is expressed in the main olfactory epithelium and in the vomeronasal organ, which also expresses the related Ano1 channel.
Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells.
Menini et al., Trieste, Italy. In J Physiol, 2010
TMEM16b/anoctamin2 is likely to be a major subunit of the native olfactory Ca(2+)-activated Cl(-) current.
Tmem16b is specifically expressed in the cilia of olfactory sensory neurons.
Neuhaus et al., Berlin, Germany. In Chem Senses, 2010
Tmem16b expression is highly specific for the OE, in contrast to the closely related Tmem16a, which shows a broad expression pattern in secretory epithelial cells.
Expression cloning of TMEM16A as a calcium-activated chloride channel subunit.
Jan et al., San Francisco, United States. In Cell, 2008
Moreover, mouse TMEM16A and TMEM16B yield CaCCs in Axolotl oocytes and mammalian HEK293 cells and recapitulate the broad CaCC expression.
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