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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Transmembrane channel-like 2

This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, expression in the inner ear suggests that it may be crucial for normal auditory function. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TMC1, TMC, HAIR, CAN, HAD
Papers on TMC2
Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells.
Marcotti et al., Sheffield, United Kingdom. In J Neurosci, Feb 2016
Transmembrane channel-like protein isoforms 1 (TMC1) and 2 (TMC2) have been proposed to form part of the MET channel, although their exact roles are still unclear.
In the Right Place at the Right Time: Is TMC1/2 the Transduction Channel for Hearing?
Corey et al., Boston, United States. In Cell Rep, Oct 2015
Recent papers suggest that TMC1 and TMC2 constitute the ion channels mediating hearing and balance.
TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia.
Kachar et al., Bethesda, United States. In Cell Rep, Oct 2015
Transmembrane channel-like 1 and 2 (TMC1 and TMC2) are essential for MET and are hypothesized to be components of the MET complex, but evidence for their predicted spatiotemporal localization in stereocilia is lacking.
Tmc gene therapy restores auditory function in deaf mice.
Holt et al., Boston, United States. In Sci Transl Med, Aug 2015
Exogenous Tmc1 or its closely related ortholog, Tmc2, were capable of restoring sensory transduction, auditory brainstem responses, and acoustic startle reflexes in otherwise deaf mice, suggesting that gene augmentation with Tmc1 or Tmc2 is well suited for further development as a strategy for restoration of auditory function in deaf patients who carry TMC1 mutations.
Gene therapy for deafness: How close are we?
Moser, Göttingen, Germany. In Sci Transl Med, Aug 2015
Virus-mediated transfer of genes encoding the mechanotransducer channel candidates TMC1 and TMC2 into hair cells of the ear partially restores hearing in animal models of human genetic deafness (Askew et al., this issue).
Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation.
Holt et al., Tokyo, Japan. In Pflugers Arch, 2015
Tmc1 and the closely related Tmc2 gene are expressed in neurosensory hair cells of the auditory and vestibular end organs of the mouse inner ear.
Mutations of TMC1 cause deafness by disrupting mechanoelectrical transduction.
Griffith et al., Bethesda, United States. In Auris Nasus Larynx, 2014
These mutant mice have been instrumental for revealing that Tmc1 and its closely related paralog Tmc2 are expressed in cochlear and vestibular hair cells, and are required for hair cell mechanoelectrical transduction (MET).
Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2.
Nicolson et al., Portland, United States. In Proc Natl Acad Sci U S A, 2014
Tmc2a is an ortholog of mammalian TMC2, which along with TMC1 has been implicated in mechanotransduction in mammalian hair cells.
Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants.
Fettiplace et al., Madison, United States. In J Gen Physiol, 2014
Transmembrane channel-like (TMC) proteins TMC1 and TMC2 are crucial to the function of the mechanotransducer (MT) channel of inner ear hair cells, but their precise function has been controversial.
TMC function in hair cell transduction.
Asai et al., Boston, United States. In Hear Res, 2014
A growing body of evidence supports a direct role for TMC1 and TMC2 as components of the transduction complex.
The role of transmembrane channel-like proteins in the operation of hair cell mechanotransducer channels.
Fettiplace et al., Madison, United States. In J Gen Physiol, 2013
Tmc1 and Tmc2, two members of the transmembrane channel-like family, are necessary for mechanotransduction.
TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear.
Holt et al., Boston, United States. In Neuron, 2013
To investigate the hypothesis that TMC1 and TMC2 proteins are components of the mechanosensitive ion channels that convert mechanical information into electrical signals, we recorded whole-cell and single-channel currents from mouse hair cells that expressed Tmc1, Tmc2, or mutant Tmc1.
tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans.
Schafer et al., Cambridge, United Kingdom. In Nature, 2013
Human TMC1 and TMC2 genes are linked to human deafness and required for hair-cell mechanotransduction; however, the molecular functions of these and other TMC proteins have not been determined.
Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel-like proteins.
Fettiplace et al., Madison, United States. In J Gen Physiol, 2013
Although the molecular identity of the MT channel remains uncertain, two members of the transmembrane channel-like family, Tmc1 and Tmc2, are crucial to hair cell mechanotransduction.
Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes.
Griffith et al., Rockville, United States. In J Clin Invest, 2011
Tmc1 is expressed in mouse vestibular & cochlear hair cells near the stereocilia tips. Deletion of Tmc1 & Tmc2 causes deafness. Deletion of only Tmc2 does not.
TMC1 but not TMC2 is responsible for autosomal recessive nonsyndromic hearing impairment in Tunisian families.
Masmoudi et al., Sfax, Tunisia. In Audiol Neurootol, 2007
Autozygosity by descent analysis of 2 markers bordering the TMC2 gene allowed us to rule out its association with deafness within these families.
Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function.
Griffith et al., Rockville, United States. In Nat Genet, 2002
TMC1 and TMC2 on chromosome 20p13 are members of a gene family predicted to encode transmembrane proteins.
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