Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.
In PLoS ONE, 2009
... Canada), anti-p115 pAb (Calbiochem, Darmstadt, Germany), anti-LAMP-1 mAb (Biolegend), anti-MPR pAb (Abcam, Cambridge, UK), anti-human TLR8 mAb (Dendritics, LYON, France) and anti-human ...
Microbial Nucleic Acid Sensing in Oral and Systemic Diseases.
Richmond, United States. In J Dent Res, Jan 2016
The discovery of innate immune activation through nucleic acid recognition by intracellular PRRs such as endosomal TLRs (TLR3, TLR7, TLR8, and TLR9) and cytoplasmic proteins (absent in melanoma 2 and DNA-dependent activator of interferon regulatory factor) opened a new paradigm: Nucleic acid sensing is now implicated in multiple immune and inflammatory conditions (e.g., atherosclerosis, cancer), viral (e.g., human papillomavirus, herpes virus) and bacterial (e.g., Helicobacter pylori, pneumonia) diseases, and autoimmune disorders (e.g., systemic lupus erythematosus, rheumatoid arthritis).
Evidence for adaptation of porcine Toll-like receptors.
Champaign, United States. In Immunogenetics, Jan 2016
The genomic sequence encoding the ectodomain, responsible for interacting with pathogen ligands of bacterial (TLR1, TLR2 and TLR6) and viral (TLR3, TLR7 and TLR8) receptors, was obtained.
Toll-like receptors as targets for allergen immunotherapy.
Tehrān, Iran. In Curr Opin Allergy Clin Immunol, Dec 2015
CRX-675 (a TLR4 agonist), AZD8848 (a TLR7 agonist), VTX-1463 (a TLR8 agonist) and 1018 ISS and QbG10 (TLR9 agonists) are currently in clinical development for allergic rhinitis and asthma.