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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Toll-like receptor 5

TLR5, Toll-Like Receptor 5
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009] (from NCBI)
Top mentioned proteins: TLR4, TLR2, TLR3, TLR9, CAN
Papers on TLR5
Association between toll-like receptor polymorphisms and systemic lupus erythematosus: a meta-analysis update.
Song et al., Seoul, South Korea. In Lupus, Feb 2016
No associations were found between rs5744168 (TLR5), rs4986791 (TLR4), rs4986790 (TLR4), and rs3775291 (TLR3) polymorphisms and SLE susceptibility.
Regulation of tissue infiltration by neutrophils: role of integrin α3β1 and other factors.
Chavakis et al., Philadelphia, United States. In Curr Opin Hematol, Jan 2016
RECENT FINDINGS: Recent findings suggest that besides the established pathways of selectin or chemokine-mediated integrin activation, signaling by distinct Toll-like receptors (TLRs) (especially TLR2, TLR4, and TLR5) can activate integrin-dependent neutrophil adhesion.
Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice.
Vijay-Kumar et al., United States. In Cell Metab, Jan 2016
Toll-like receptor 5 (TLR5), a flagellin receptor, is required for gut microbiota homeostasis.
MicroRNA-induced negative regulation of TLR-5 in grass carp, Ctenopharyngodon idella.
Li et al., Shanghai, China. In Sci Rep, Dec 2015
Bioinformatics analysis and overexpressing assay shows that cid-miRn-115 and miR-142a-3p directly regulate tlr5 expression.
Toll-like receptors: potential targets for lupus treatment.
Zuo et al., Shanghai, China. In Acta Pharmacol Sin, Dec 2015
Genome-wide association studies, experimental mouse models and clinical sample studies have provided evidence for the involvement of TLRs, including TLR2/4, TLR5, TLR3 and TLR7/8/9, in SLE pathogenesis.
Functional properties of flagellin as a stimulator of innate immunity.
Swartz et al., Stanford, United States. In Sci Rep, Dec 2015
Surprisingly, attaching only 2 flagellins per VLP provided the same 1 pM potency as did VLPs with about 33 attached flagellins suggesting that the TLR5 receptor is highly effective in delivering its intracellular signal.
Reptile Toll-like receptor 5 unveils adaptive evolution of bacterial flagellin recognition.
van Putten et al., Utrecht, Netherlands. In Sci Rep, Dec 2015
Here we report the cloning, characterization, and function of TLR5 of the reptile Anolis carolinensis (Green Anole lizard).
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.
Ji et al., Durham, United States. In Nat Med, Nov 2015
We found that Toll-like receptor 5 (TLR5) is co-expressed with neurofilament-200 in large-diameter A-fiber neurons in the dorsal root ganglion (DRG).
T-Regulatory Cells as Part of Strategy of Immune Evasion by Pathogens.
Rizopulu et al., Moscow, Russia. In Biochemistry (mosc), Aug 2015
Costimulation of Toll-like receptor 5 (TLR5) by flagellin increases the expression of the transcription factor Foxp3, which increases the suppressive activity of Treg cells.
Common TLR5 mutations control cancer progression.
Pittet et al., Boston, United States. In Cancer Cell, Feb 2015
In this issue of Cancer Cell, Rutkowski and colleagues indicate that TLR5 signaling deficiency, which occurs in ∼10% of the population, changes interactions with commensal microbiota and deregulates a cascade of inflammatory events that can suppress or accelerate extraintestinal cancers.
Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation.
Conejo-Garcia et al., Philadelphia, United States. In Cancer Cell, Feb 2015
The dominant TLR5(R392X) polymorphism abrogates flagellin responses in >7% of humans.
Polymorphisms in the Toll-Like Receptor and the IL-23/IL-17 Pathways Were Associated with Susceptibility to Inflammatory Bowel Disease in a Danish Cohort.
Andersen et al., Viborg, Denmark. In Plos One, 2014
RESULTS: The polymorphisms TLR5 (rs5744174) and IL12B (rs6887695) were associated with risk of CD, and TLR1 (rs4833095) and IL18 (rs187238) were associated with risk of both CD and UC (p<0.05).
Comparative Geometrical Analysis of Leucine-Rich Repeat Structures in the Nod-Like and Toll-Like Receptors in Vertebrate Innate Immunity.
Kretsinger et al., Sapporo, Japan. In Biomolecules, 2014
This geometrical analysis subdivides TLRs into four groups consisting of TLR3/TLR8/TLR9, TLR1/TLR2/TRR6, TLR4, and TLR5; these correspond to the phylogenetic tree based on amino acid sequences.
Crosstalk Between The Immune Receptors and Gut Microbiota.
Zhu et al., Nanjing, China. In Curr Protein Pept Sci, 2014
Deficiency in PRRs such as NOD2 and TLR5 can alter the gut microbiota composition in mice.
Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18.
Gewirtz et al., Atlanta, United States. In Science, 2014
Protection was independent of adaptive immunity and interferon (IFN, type I and II) and required flagellin receptors Toll-like receptor 5 (TLR5) and NOD-like receptor C4 (NLRC4).
Airway epithelial expression of TLR5 is downregulated in healthy smokers and smokers with chronic obstructive pulmonary disease.
Crystal et al., New York City, United States. In J Immunol, 2012
TLR5 is expressed mainly on the apical side of the airway epithelium and is decreased in healthy smokers and smokers with chronic obstructive pulmonary disease (COPD).
Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation.
Turpeinen et al., Helsinki, Finland. In Scand J Immunol, 2012
The results showed that the genetic markers in TLR1, TLR4, TLR5 TLR6, and TLR10 were associated with the occurrence of acute Graft-versus-host disease following hematopoietic stem cell transplantation
TLR5, a novel and unidentified inflammatory mediator in rheumatoid arthritis that correlates with disease activity score and joint TNF-α levels.
Shahrara et al., Chicago, United States. In J Immunol, 2012
TLR5 ligation has a potential role in modulating transcription of tumor necrosis factor (TNF)-alpha in rheumatoid arthritis (RA) synovial fluid, strongly correlating TLR5 and TNF-alpha with each other and with RA disease activity in peripheral blood monocytes.
Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing.
Sallenave et al., Paris, France. In Proc Natl Acad Sci U S A, 2012
findings demonstrate that TLR5 engagement plays a major role in P. aeruginosa internalization and in triggering IL-1beta formation
Regulation of Toll-like receptor 5 gene expression and function on mucosal dendritic cells.
Elson et al., Birmingham, United States. In Plos One, 2011
Mucosal dendritic cells (DCs), but not splenic DCs, express high levels of Tlr5 protein.
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