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proteins. Page last changed on 19 Dec 2016.
Toll-like receptor 3
TLR3, Toll-Like Receptor 3
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
TLR4, ACID, CAN, TLR2, V1a
Papers using
TLR3
antibodies
Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity
Supplier
In Journal of Biomedical Science, 2003
... The slides were then washed twice with PBS, incubated with TLR3 antibody (1:2000 dilution; Abcam, Cambridge, MA, USA) at ...
Papers on
TLR3
Poly(I:C) potentiates Bacillus Calmette-Guérin immunotherapy for bladder cancer.
New
Québec, Canada. In Cancer Immunol Immunother, Feb 2016
We previously showed that human urothelial cells express functional TLRs and respond to TLR2 and TLR3 agonists.
Association between toll-like receptor polymorphisms and systemic lupus erythematosus: a meta-analysis update.
New
Seoul, South Korea. In Lupus, Feb 2016
No associations were found between rs5744168 (TLR5), rs4986791 (TLR4), rs4986790 (TLR4), and rs3775291 (TLR3) polymorphisms and SLE susceptibility.
A novel rabies vaccine based-on toll-like receptor 3 (TLR3) agonist PIKA adjuvant exhibiting excellent safety and efficacy in animal studies.
New
Beijing, China. In Virology, Feb 2016
PIKA, a stabilized chemical analog of double-stranded RNA that interacts with TLR3, was employed as adjuvant of rabies vaccine.
Human Milk Components Modulate Toll-Like Receptor-Mediated Inflammation.
Review
New
Boston, United States. In Adv Nutr, Jan 2016
Human milk on the whole is strongly anti-inflammatory, and contains abundant components that depress TLR signaling pathways: sTLR2 and sCD14 inhibit TLR2 signaling; sCD14, lactadherin, lactoferrin, and 2'-fucosyllactose attenuate TLR4 signaling; 3'-galactosyllactose inhibits TLR3 signaling, and β-defensin 2 inhibits TLR7 signaling.
Toll-like receptors: potential targets for lupus treatment.
Review
New
Shanghai, China. In Acta Pharmacol Sin, Dec 2015
Genome-wide association studies, experimental mouse models and clinical sample studies have provided evidence for the involvement of TLRs, including TLR2/4, TLR5, TLR3 and TLR7/8/9, in SLE pathogenesis.
Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia.
New
Belo Horizonte, Brazil. In J Neuroinflammation, Dec 2015
Polyinosinic-polycytidylic acid [poly(I:C)] is a synthetic analog of dsRNA that activates different molecules, such as retinoic acid-inducible gene I, melanoma differentiation-associated gene 5, and toll-like receptor-3 (TLR3).
Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock.
New
Impact
Ann Arbor, United States. In Immunity, Dec 2015
Priming the caspase-11 pathway in vivo with LPS or Toll-like receptor-3 (TLR3) agonist resulted in high mortality in wild-type mice after secondary LPS challenge, but not in Casp11(-/-), Panx1(-/-), or P2x7(-/-) mice.
Genetic Predisposition to Stevens-Johnson Syndrome With Severe Ocular Surface Complications.
Review
New
Kyoto, Japan. In Cornea, Nov 2015
Moreover, HLA-A*02:06 with TLR3 polymorphisms and HLA-A*02:06 with EP3 polymorphisms exerted additive effects in SJS/TEN with SOCs.
[Mechanisms of Epstein-Barr Virus-Mediated Oncogenesis].
Review
New
Kōbe, Japan. In Gan To Kagaku Ryoho, Oct 2015
However, it has also been demonstrated that EBER, which is expected to have a double-stranded RNA(dsRNA)structure, triggers signal transduction via host viral RNA sensors, RIG-I and TLR3, causing EBV-associated pathogenesis, including carcinogenesis.
[Clinical characteristics, prognosis and genetic susceptibility of herpes simplex encephalitis in children].
New
Beijing, China. In Zhonghua Er Ke Za Zhi, Sep 2015
OBJECTIVE: To summarize the clinical characteristics and long-term prognosis of herpes simplex virus encephalitis (HSE) in childhood and to analyze genotype of UNC93B1 and TLR3.
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.
New
Impact
Baltimore, United States. In Cell, Sep 2015
Knocking down dsRNA sensors TLR3 and MAVS reduces this response 2-fold and blocking interferon beta or its receptor abrogates it.
dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration.
New
Impact
Baltimore, United States. In Cell Stem Cell, Sep 2015
Here, we show that dsRNA, which is released from damaged skin, activates Toll-Like Receptor 3 (TLR3) and its downstream effectors IL-6 and STAT3 to promote hair follicle regeneration.
Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV).
Review
Sapporo, Japan. In Sensors (basel), 2014
Human hepatocytes barely express TLR3 under non-infectious states, but frequently express it in HCV infection.
Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.
Impact
Villejuif, France. In Nat Med, 2014
Here we demonstrate that anthracyclines stimulate the rapid production of type I interferons (IFNs) by malignant cells after activation of the endosomal pattern recognition receptor Toll-like receptor 3 (TLR3).
Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage.
Impact
Freiburg, Germany. In Nat Med, 2014
In contrast, when we transferred neutrophils lacking Toll-like receptor-2 (TLR2), TLR3, TLR4, TLR7 and TLR9, which are normally less strongly activated by translocating bacteria, into wild-type C57BL/6 mice, GVHD severity was reduced.
Overexpression of toll-like receptor 3 in spleen is associated with experimental arthritis in rats.
GeneRIF
Xi'an, China. In Scand J Immunol, 2012
we conclude that overexpression of splenic TLR3 is strongly associated with arthritis in rats
Toll-like receptor 3 polymorphism and its association with hepatitis B virus infection in Saudi Arabian patients.
GeneRIF
Riyadh, Saudi Arabia. In J Med Virol, 2012
Genetic variations in the TLR3 gene could affect the outcome of hepatitis B virus infection among Saudis.
Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood.
GeneRIF
New York City, United States. In J Exp Med, 2012
TBK1 is essential for the TLR3- and IFN-dependent control of HSV-1 in the central nervous system
Toll-like receptor (TLR) 3 as a surrogate sensor of retroviral infection in human cells.
GeneRIF
Tokyo, Japan. In Biochem Biophys Res Commun, 2012
These data clearly indicated that retroviral infection exemplified by xenotropic murine leukemia virus-relamoted virus activates the TLR3 signal in human cells.
Toll-like receptor 3 activation affects serotonin transporter activity and expression in human enterocyte-like Caco-2 cells.
GeneRIF
Zaragoza, Spain. In Cell Physiol Biochem, 2011
TLR3 inhibits SERT activity, which may increase 5-HT extracellular levels and contribute to the inflammatory response
