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Toll-like receptor 2

TLR2, Toll-Like Receptor 2
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TLR4, Interleukin-6, V1a, CAN, MyD88
Papers using TLR2 antibodies
Toll-like receptor 2 mediates invasion via activating NF-kappaB in MDA-MB-231 breast cancer cells
Seymour G J et al., In British Journal of Cancer, 2008
... Immunohistochemical staining was performed using a monoclonal mouse antibody against TLR2.1 (sc-21759, Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Immunization with the truncated adhesin Moraxella catarrhalis immunoglobulin D-binding protein (MID764-913) is protective against M. catarrhalis in a mouse model of pulmonary clearance.
Stevenson Freda Kathryn, In PLoS Pathogens, 2003
... FITC-conjugated mouse anti-human TLR9 and anti-human TLR2 mAbs were obtained from Imgenex (San Diego, CA) ...
Transformation fingerprint: induced STAT3-C, v-Src and Ha-Ras cause small initial changes but similar established profiles in mRNA.
Zimmer Jacques, In PLoS ONE, 2003
... TLR2-neutralizing mAb (clone mT2.4) was from Abcam (Cambridge, UK) and anti-TLR4 ...
Helicobacter pylori strains expressing the vacuolating cytotoxin interrupt phagosome maturation in macrophages by recruiting and retaining TACO (coronin 1) protein
Makino Masahiko et al., In Acta Histochemica et Cytochemica, 2002
... Pieters (Basel Institute for Immunology, Basel, Switzerland), rabbit anti-human Toll-like receptor 2 (TLR2) antibody (Santa Cruz Biotechnology, Santa Cruz, CA) or ...
Temporal Interleukin-1β Secretion from Primary Human Peripheral Blood Monocytes by P2X7-independent and P2X7-dependent Mechanisms*
Wilson Heather L. et al., In The Journal of Biological Chemistry, 2000
... For TLR2 agonists, MALP-2 was from Axxora (Nottingham, UK), and Pam ...
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Papers on TLR2
How the innate immune system trains immunity: lessons from studying atopic dermatitis and cutaneous bacteria.
Biedermann et al., München, Germany. In J Dtsch Dermatol Ges, Feb 2016
In this review, we present data on how the innate immune system actually fine-tunes its responses with special focus on the immunological consequences of cutaneous innate immune sensing through TLR2.
Differential activation of innate immune pathways by distinct islet amyloid polypeptide (IAPP) aggregates.
Verchere et al., Canada. In J Biol Chem, Feb 2016
Soluble IAPP species produced early during IAPP aggregation provided a Toll-like-receptor-2- (TLR2-) dependent stimulus for NF-κB activation in HEK 293 cells and bone marrow-derived macrophages (BMDMs).
Primary role for TLR-driven TNF rather than cytosolic immune detection in restricting Coxiella burnetii phase II replication within mouse macrophages.
Shin et al., Ribeirão Preto, Brazil. In Infect Immun, Feb 2016
In addition to the known role of TLR2 in detecting and restricting NMII infection, we found that TLR4 also contributes to cytokine responses but is not required to restrict bacterial replication.
Roles of TLR2, TLR4, and MyD88 during pulmonary Coxiella burnetii infection.
Jutila et al., Bozeman, United States. In Infect Immun, Feb 2016
Previous studies examined the roles of the innate immune system receptors, TLR2 and TLR4, in peripheral infection models and described minimal phenotypes in specific gene deletion animals compared to their wildtype controls.
TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review.
Babu et al., India. In Braz J Infect Dis, Feb 2016
TLR2 and TLR4 have gained immense importance due to their extreme ability of identifying distinct molecular patterns from invading pathogens.
Human Milk Components Modulate Toll-Like Receptor-Mediated Inflammation.
Newburg et al., Boston, United States. In Adv Nutr, Jan 2016
Human milk on the whole is strongly anti-inflammatory, and contains abundant components that depress TLR signaling pathways: sTLR2 and sCD14 inhibit TLR2 signaling; sCD14, lactadherin, lactoferrin, and 2'-fucosyllactose attenuate TLR4 signaling; 3'-galactosyllactose inhibits TLR3 signaling, and β-defensin 2 inhibits TLR7 signaling.
The role of altered cutaneous immune responses in the induction and persistence of rosacea.
Kavanagh et al., Ireland. In J Dermatol Sci, Jan 2016
Alterations in the immune response include elevated levels of LL-37 in rosacea skin, increased expression of TLR-2 and increased amounts of vitamin D3 in epidermal tissue.
Effects of the New Generation Synthetic Reconstituted Surfactant CHF5633 on Pro- and Anti-Inflammatory Cytokine Expression in Native and LPS-Stimulated Adult CD14+ Monocytes.
Speer et al., Würzburg, Germany. In Plos One, Dec 2015
Potential effects on TLR2 and TLR4 mRNA and protein expression were monitored by qPCR and flow cytometry.
Helicobacter pylori activates the TLR2/NLRP3/caspase-1/IL-18 axis to induce regulatory T-cells, establish persistent infection and promote tolerance to allergens.
Müller et al., Zürich, Switzerland. In Gut Microbes, Dec 2015
H. pylori predominantly activates the NLRP3 inflammasome through a process that requires TLR2-dependent licensing.
Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.
Ivashkiv et al., New York City, United States. In Nat Immunol, Aug 2015
Genome-wide ribosome profiling in TLR2-stimulated macrophages showed that IFN-γ selectively modulated the macrophage translatome to promote inflammation, further reprogram metabolic pathways and modulate protein synthesis.
Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells.
Yoshimura et al., Tokyo, Japan. In Immunity, Aug 2015
C. butyricum-mediated TGF-β1 induction was mainly Toll-like receptor 2 (TLR2) dependent, and the ERK-AP-1 kinase pathway played an important role.
Toll-like receptor 2 (TLR2) is a marker of angiogenesis in the necrotic area of human medulloblastoma.
Szukiewicz et al., Warsaw, Poland. In Folia Neuropathol, 2014
In this context, the aim of our present study was to examine in medulloblastoma the distribution of Toll-like receptor 2 (TLR2) and receptor for advanced glycosylation end-product (RAGE), and mast cells associated with the tumor neovascularization process.
A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis.
Clarke et al., Stanford, United States. In Nat Cell Biol, 2014
Here we describe a role for cell-intrinsic toll-like receptor-2 (TLR2; which is involved in inflammatory response) signalling in normal intestinal and mammary epithelial cells and oncogenesis.
"Toll"-erance in the skin.
Falo et al., Pittsburgh, United States. In Immunity, 2014
(2014) show that S. aureus-derived TLR2/6 heterodimer ligands can recruit myeloid-derived suppressor cells into the skin, countering rather than promoting inflammation.
Cutaneous innate immune sensing of Toll-like receptor 2-6 ligands suppresses T cell immunity by inducing myeloid-derived suppressor cells.
Biedermann et al., Tübingen, Germany. In Immunity, 2014
Skin exposure to Toll-like receptor (TLR)2-6-binding lipopeptides, but not TLR2-1-binding lipopeptides, potently suppressed immune responses through induction of Gr1(+)CD11b(+) myeloid-derived suppressor cells (MDSCs).
Complement activation and toll-like receptor-2 signaling contribute to cytokine production after renal ischemia/reperfusion.
Thurman et al., Aurora, United States. In Mol Immunol, 2012
study found that complement activation, TLR-2, and TLR4 signaling can each induce tubular epithelial cells to produce an overlapping array of pro-inflammatory cytokines after renal ischemia/reperfusion
Nod2 improves barrier function of intestinal epithelial cells via enhancement of TLR responses.
den Haan et al., Amsterdam, Netherlands. In Mol Immunol, 2012
studies show that via the enhancement of TLR2 signaling, Nod2 is important for maintenance of barrier function in Intestinal epithelial cells.
Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis.
Hawn et al., Seattle, United States. In J Immunol, 2012
These data demonstrate that TOLLIP has an anti-inflammatory effect on TLR2 and TLR4 signaling in humans
ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes.
Hellman et al., San Francisco, United States. In J Biol Chem, 2012
study newly identifies ERK5 as a key regulator of TLR2 signaling in EC and monocytes and indicates that there are fundamental differences in TLR signaling pathways between EC and monocytes
Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity.
Wan et al., Dallas, United States. In Genes Dev, 2012
Neonatal toxicity requires Toll-like-receptors (TLR), but not gut microbiota, because TLR2/4 deletion or TLR4 inhibition confers resistance, whereas germ-free mice remain sensitive.
More papers using TLR2 antibodies
Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region.
Ramakrishnan Lalita, In PLoS Pathogens, 1997
... TLR2/4 double-deficient mice were created by Shizuo Akira (Osaka University), generously supplied by Lynn Hajjar (University of Washington), and were bred at the Cornell University Transgenic Mouse Core Facility ...
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