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Toll-like receptor 10

TLR10, Toll-Like Receptor 10
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: Toll-like receptor, TLR2, TLR6, TLR4, TLR9
Papers on TLR10
Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes.
Quintana-Murci et al., Paris, France. In Am J Hum Genet, Feb 2016
Notably, among the genes presenting the highest Neandertal ancestry, we find the TLR6-TLR1-TLR10 cluster, which also contains functional adaptive variation in Europeans.
Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors.
Kelso et al., Leipzig, Germany. In Am J Hum Genet, Feb 2016
Here we document a cluster of three Toll-like receptors (TLR6-TLR1-TLR10) in modern humans that carries three distinct archaic haplotypes, indicating repeated introgression from archaic humans.
Toll-like receptor 10 expression in chicken, cattle, pig, dog, and rat lungs.
Singh et al., Canada. In Vet Immunol Immunopathol, Jan 2016
TLR10 is identified as type 1 plasma membrane protein but the identity of its ligand remains unclear.
Gene Polymorphism of Toll-Like Receptors and Lung Function at Five to Seven Years of Age after Infant Bronchiolitis.
Korppi et al., Tampere, Finland. In Plos One, Dec 2015
Data on single nucleotide polymorphisms (SNP) of TLR1 rs5743618, TLR2 rs5743708, TLR6 rs5743810 and TLR10 rs4129009 (TLR2 subfamily) and TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992 and TLR 9 rs187084 were available for analyses.
Expression and function of toll-like receptors in human circulating endothelial colony forming cells.
Stronati et al., Pavia, Italy. In Immunol Lett, Nov 2015
We expanded and differentiated in vitro umbilical cord blood (UCB) and adult peripheral blood (PB) ECFCs and studied the expression of TLR1 to TLR10 mRNA by qPCR analysis, and we further characterized TLR function in ECFCs through functional assays including in vitro ECFC growth and differentiation, assessment of cytokine production, and measurement of intracellular Ca(2+) signals.
Genetic Variations in Pattern Recognition Receptor Loci Are Associated with Anti-TNF Response in Patients with Rheumatoid Arthritis.
Andersen et al., Copenhagen, Denmark. In Plos One, 2014
CONCLUSIONS: We reproduced previously reported associations between genetic variation in the TLR10/1/6 gene cluster, TLR5, and NLRP3 loci and response to anti-TNF treatment in RA.
Expression profiling and functional analysis of Toll-like receptors in primary healthy human nasal epithelial cells shows no correlation and a refractory LPS response.
van Drunen et al., Amsterdam, Netherlands. In Clin Transl Allergy, 2014
We were unable to detect mRNA of TLR7, TLR8 and TLR10.
Polymorphisms at Locus 4p14 of Toll-Like Receptors TLR-1 and TLR-10 Confer Susceptibility to Gastric Carcinoma in Helicobacter pylori Infection.
Vadivelu et al., Kuala Lumpur, Malaysia. In Plos One, 2014
TLR-1 SNPs rs4833095 and TLR-10 SNPs rs10004195 and were directly associated with H. pylori disease, and were up-regulated in the presence of H. pylori in a genotype-independent manner.
Polymorphisms in Toll-like receptor genes are associated with vitiligo.
Kingo et al., Tartu, Estonia. In Front Genet, 2014
METHODS: In order to conduct a genetic association analysis, 30 SNPs were selected from TLR1-TLR8 and TLR10 regions to be genotyped in Estonian case-control cohort consisting of 139 vitiligo patients and 307 healthy control individuals.
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
Tung et al., Mountain View, United States. In Nat Genet, 2013
We identified 16 shared susceptibility loci with association P<5×10(-8), including 8 loci previously associated with asthma, as well as 4p14 near TLR1, TLR6 and TLR10 (rs2101521, P=5.3×10(-21)); 6p21.33 near HLA-C and MICA (rs9266772, P=3.2×10(-12)); 5p13.1 near PTGER4 (rs7720838, P=8.2×10(-11)); 2q33.1 in PLCL1 (rs10497813, P=6.1×10(-10)), 3q28 in LPP (rs9860547, P=1.2×10(-9)); 20q13.2 in NFATC2 (rs6021270, P=6.9×10(-9)), 4q27 in ADAD1 (rs17388568, P=3.9×10(-8)); and 14q21.1 near FOXA1 and TTC6 (rs1998359, P=4.8×10(-8)).
Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation.
Turpeinen et al., Helsinki, Finland. In Scand J Immunol, 2012
The results showed that the genetic markers in TLR1, TLR4, TLR5 TLR6, and TLR10 were associated with the occurrence of acute Graft-versus-host disease following hematopoietic stem cell transplantation
Genetic variation within TLR10 is associated with Crohn's disease in a New Zealand population.
Ferguson et al., Auckland, New Zealand. In Hum Immunol, 2012
genetic variation in TLR10 plays a role in interindividual differences in CD susceptibility and clinical outcome.
Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis.
Grutters et al., Nieuwegein, Netherlands. In Tissue Antigens, 2012
absence of the common haplotype in the TLR10-TLR1-TLR6 gene cluster increases the risk of developing chronic disease in patients already affected by sarcoidosis.
Association of Toll-like receptor 10 and susceptibility to Crohn's disease independent of NOD2.
García-Lozano et al., Sevilla, Spain. In Genes Immun, 2011
Our results support association of the TLR10 gene with CD susceptibility. The effect of TLR10 would be independent of NOD2, suggesting different signaling pathways for both genes.
Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.
Kutikhin, Kemerovo, Russia. In Hum Immunol, 2011
The short list of TLR polymorphisms perspective for oncogenomic investigations can include rs10008492, rs4833103, rs5743815, rs11466657, rs7696175 (TLR1-TLR6-TLR10 gene cluster); rs3804100, rs4696480, -196 - -174 del (Delta22), GT-microsatellite polymorphism (TLR2); 829A/C (TLR3); rs5743836, rs352140 (TLR9).
Increased expression of hepcidin and toll-like receptors 8 and 10 in viral keratitis.
Dua et al., Nottingham, United Kingdom. In Cornea, 2011
Quantitative polymerase chain reaction showed significantly higher expression of LEAP-1 (P = 0.002) and TLR-8 (P = 0.023) and TLR-10 (P = 0.014) in viral keratitis and LEAP-2 (P = 0.034) in dry eye, versus controls.
Toll-like receptor signaling in bony fish.
Seyfert et al., Germany. In Vet Immunol Immunopathol, 2010
The orthologues of human TLR6 and TLR10 are also absent in teleosts.
[Mast cell Toll-like receptors (TLRs)].
Wierzbicki et al., Łódź, Poland. In Postepy Hig Med Dosw (online), 2009
The presence of TLR7, TLR9, and TLR10 on mast cells is still unclear.
The role of Toll-like receptors and related receptors of the innate immune system in asthma.
Holloway et al., Brisbane, Australia. In Curr Opin Allergy Clin Immunol, 2006
RECENT FINDINGS: The majority of studies published since 2004 have been genetic association studies in various clinical settings, which have found positive associations of single nucleotide polymorphisms in TLR2, TLR4, TLR6 and TLR10 with asthma or atopy, although the number of studies is small and the results not yet replicated.
[Toll type receptors: molecular bases of the relationship between innate and adaptation responses of the immune system].
Sánchez-Ibarrola et al., In Rev Med Univ Navarra, 2003
So far, ten mammalian toll-like receptors (TLR1-TLR10) have been identified.
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