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Tolloid-like 2

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TLL, myostatin, Bone morphogenetic protein, fibrillin-1, GM-CSF
Papers on Tll2
Cross-training in birds: cold and exercise training produce similar changes in maximal metabolic output, muscle masses and myostatin expression in house sparrows (Passer domesticus).
Swanson et al., United States. In J Exp Biol, Jul 2015
To examine whether such correlations occur, we measured the effects of experimental cold and exercise training protocols for 3 weeks on body (Mb) and muscle (Mpec) masses, basal metabolic rate (BMR), Msum, MMR, pectoralis mRNA and protein expression for myostatin, and mRNA expression of TLL-1 and TLL-2 (metalloproteinase activators of myostatin) in house sparrows (Passer domesticus).
Phenotypic flexibility of skeletal muscle and heart masses and expression of myostatin and tolloid-like proteinases in migrating passerine birds.
Swanson et al., United States. In J Comp Physiol B, Apr 2015
A potential mechanism for increasing muscle and heart masses during migration in birds is the muscle growth inhibitor myostatin and its metalloproteinase activators, tolloid-like proteinases (TLL-1 and TLL-2).
Covalent attachment of lipases on glyoxyl-agarose beads: application in fruit flavor and biodiesel synthesis.
Giordano et al., Alfenas, Brazil. In Int J Biol Macromol, 2014
Lipase preparations Lipolase® (TLL1) and Lipex® 100 L (TLL2) from Thermomyces lanuginosus and Lipase AK from Pseudomonas fluorescens (PFL) were immobilized on glyoxyl-agarose beads prepared by activation with glycidol (Gly) and epichlorohydrin (Epi).
Seasonal variation in pectoralis muscle and heart myostatin and tolloid-like proteinases in small birds: a regulatory role for seasonal phenotypic flexibility?
Harmon et al., United States. In J Comp Physiol B, 2014
We examined summer-to-winter variation in skeletal muscle and heart masses and used qPCR and Western blots to measure levels of myostatin and its metalloproteinase activators TLL-1 and TLL-2 for two small temperate-zone resident birds, American goldfinches (Spinus tristis) and black-capped chickadees (Poecile atricapillus).
NCI-60 whole exome sequencing and pharmacological CellMiner analyses.
Pommier et al., Campo Grande, Brazil. In Plos One, 2013
These include genes of known pharmacological importance such as IGF1R, BRAF, RAD52, MTOR, STAT2 and TSC2 as well as a large number of candidate genes such as NOM1, TLL2, and XDH.
Cross-species genetics converge to TLL2 for mouse avoidance behavior and human bipolar disorder.
Kas et al., Utrecht, Netherlands. In Genes Brain Behav, 2013
By means of a comparative genetic strategy within the human homologous region, we describe an association for TLL2 with bipolar disorder using the genome-wide association study (GWAS) data set generated by the Wellcome Trust Case Control Consortium (WTCCC).
Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation.
Lindsay et al., Boulder, United States. In J Physiol Sci, 2010
The purpose of this work was to examine the expression of BMP-1/mTLD, tolloid-like-1 and -2 (TLL1 and TLL2) in hindlimb muscles of the mouse in vivo and in C(2)C(12) muscle cells in vitro.
Seasonal variation of myostatin gene expression in pectoralis muscle of house sparrows (Passer domesticus) is consistent with a role in regulating thermogenic capacity and cold tolerance.
Clark et al., United States. In Physiol Biochem Zool, 2009
As a first step toward examining such a role for myostatin in small birds, we measured summer and winter gene expression of myostatin and its potential metalloproteinase activators TLL-1 and TLL-2 in house sparrows from southeastern South Dakota.
Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.
Gerhartz et al., Basel, Switzerland. In J Mol Biol, 2009
The crystal structures of the protease domains of human BMP-1 and the closely related Tolloid-like protease 1 (TLL-1), are reported.
Genetic analysis of the role of proteolysis in the activation of latent myostatin.
Lee, Baltimore, United States. In Plos One, 2007
loss-of-function mutation in Tll2, has a small, but significant, effect on muscle mass
Characterization of a novel reptilian tolloid-like gene in the pond turtle, Pseudemys scripta elegans.
Clark et al., United States. In Brain Res, 2007
Sequence analysis of tTll revealed that it is most closely related to chicken Tll-2 although tTll domain structure is different.
Germ line insertions of moloney murine leukemia virus in the TLL mouse causes site-specific differences in lymphoma/leukemia frequency and tumor immunophenotype.
Holmberg et al., Umeå, Sweden. In Anticancer Res, 2006
RESULTS: Two independent Mo-MLV germ line integrations were characterized on chromosomes 2 and 14, giving rise to two substrains of mice denoted TLL-2 and TLL-14.
An anti-CD2 monoclonal antibody that both inhibits and stimulates T cell activation recognizes a subregion of CD2 distinct from known ligand-binding sites.
Fox et al., Ann Arbor, United States. In Cell Immunol, 1993
In functional studies, the combination of UMCD2 plus anti-Tll3 was mitogenic for T cells; in some individuals, the level of activation was as high as that seen for the combination of anti-Tll2 plus anti-Tll3.
Production of macrophage-, granulocyte-, granulocyte-macrophage- and multi-colony-stimulating factor by peripheral blood cells.
Herrmann et al., Mainz, Germany. In Eur J Immunol, 1989
When Mo or T lymphocytes were exposed to recombinant human interferon-gamma or were stimulated by triggering the epitopes recognized by the monoclonal antibodies anti-Tll2 and Tll3, respectively, again disparate CSF expression patterns were found to be associated with both cell species.
Regulation of gene expression of M-, G-, GM-, and multi-CSF in normal and malignant hematopoietic cells.
Herrmann et al., Mainz, Germany. In Blood Cells, 1987
More physiologically, when Mo were activated with interferon (IFN)-gamma or tumor necrosis factor-alpha (TNF-alpha) and T-lymphocytes were stimulated in an Mo-independent pathway, that is via triggering of the 50 kd sheep erythrocyte receptor protein employing monoclonal antibodies (mo ab) to the Tll-2- and Tll-3- defined epitopes, similar kinetics of mRNA expression were obtained.
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