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Transducin-like enhancer of split 3

TLE3, Grg3, rTLE3
may be involved in transcription regulation in the CNS both during development and in the adult [RGD, Feb 2006] (from NCBI)
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Top mentioned proteins: TLE2, Insulin, OUT, HAD, HNF-3
Papers on TLE3
MiR-744 increases tumorigenicity of pancreatic cancer by activating Wnt/β-catenin pathway.
Liu et al., Wuhan, China. In Oncotarget, Dec 2015
In the current study, we demonstrated that upregulation of miR-744 in pancreatic cancer promoted Wnt/β-catenin signaling by directly targeting secreted frizzled-related protein 1 (SFRP1), glycogen synthase kinase 3β (GSK3β), and transducin-like enhancer of split 3 (TLE3), important negative modulators of Wnt/β-catenin signaling.
Genetic loci that regulate ectopic calcification in response to knee trauma in LG/J by SM/J advanced intercross mice.
Sandell et al., Saint Louis, United States. In J Orthop Res, Oct 2015
Functional and bioinformatic analyses of single nucleotide polymorphism (SNP) identified functional classifications relevant to angiogenesis (Myo1e, Kif26b, Nprl3, Stab2, Fam105b), bone metabolism/calcification (Tle3, Tgfb2, Lipc, Nfe2l1, Ank, Fam105b), arthritis (Stab2, Tbx21, Map4k4, Hoxb9, Larp6, Col1a2, Adam10, Timp3, Nfe2l1, Trpm3), and ankylosing-spondylitis (Ank, Pon1, Il1r2, Tbkbp1) indicating that ectopic calcification involves multiple mechanisms.
TLE3 is not a predictive biomarker for taxane sensitivity in the NCIC CTG MA.21 clinical trial.
NCIC CTG et al., Toronto, Canada. In Br J Cancer, Oct 2015
BACKGROUND: TLE3, a nuclear transcriptional repressor downstream of WNT signalling pathways, has been hypothesised as predictive of benefit from adjuvant taxane.
FOXA2 attenuates the epithelial to mesenchymal transition by regulating the transcription of E-cadherin and ZEB2 in human breast cancer.
Tan et al., Changsha, China. In Cancer Lett, Jul 2015
Meanwhile, FOXA2 prevented EMT of breast cancer cells by repressing the expression of EMT-related transcription factor ZEB2 through recruiting a transcriptional corepressor TLE3 to the ZEB2 promoter.
Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression.
Brickman et al., Edinburgh, United Kingdom. In Dev Biol, 2015
To explore the role of Gro/TLE in more detail we generated an allelic series of knockout ESCs of two TLE genes expressed most dynamically in early differentiation, TLE3 and TLE4.
Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.
Fernández-Real et al., Girona, Spain. In J Mol Med (berl), 2015
UNLABELLED: Transgenic overexpression of adipose tissue (AT) transducin-like enhancer of split 3 (TLE3) mimicked peroxisome proliferator-activated receptor gamma (PPARγ) agonists, improving insulin resistance in mice.
The transcriptional co-repressor TLE3 suppresses basal signaling on a subset of estrogen receptor α target genes.
Gévry et al., Sherbrooke, Canada. In Nucleic Acids Res, 2014
Here, we show that in breast cancer MCF-7 cells, TLE3, a co-repressor of the Groucho/Grg/TLE family, interacts with FoxA1 and is detected at regulatory elements of ERα target genes in absence of estrogen.
Foxa1 contributes to the repression of Nanog expression by recruiting Grg3 during the differentiation of pluripotent P19 embryonal carcinoma cells.
Tan et al., Taiwan. In Exp Cell Res, 2014
We confirmed that Foxa1 was able to interact with Grg3, which is a transcriptional corepressor that expresses in P19 cells as well as during RA-induced P19 cell differentiation.
Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functions.
Zaret et al., Philadelphia, United States. In Diabetes, 2014
We show that the corepressor Grg3 is expressed in almost all β-cells throughout embryogenesis to adulthood.
DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/β-catenin signaling pathway genes.
Nilsson et al., Örebro, Sweden. In Epigenomics, 2014
RESULTS: We found significantly aberrant methylation in 23 genes (NEIL1, NEIL3, DCLRE1C, NHEJ1, GTF2H5, CCNH, CTNNB1, DKK2, DKK3, FZD5 LRP5, TLE3, WNT2, WNT3A, WNT6, TCF7L1, CASP8, EDNRB1, GPC6, KIAA1804, MYO1B, SMAD2 and TTN).
Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling.
Yoda et al., Morohongō, Japan. In Febs Lett, 2014
Transducing-like enhancer of split 3 (TLE3), one of the Groucho/TLE family members, targets Runx2 transcription and suppresses osteoblast differentiation in bone marrow stromal cells (BMSCs).
Topoisomerase II alpha and TLE3 as predictive markers of response to anthracycline and taxane-containing regimens for neoadjuvant chemotherapy in breast cancer.
Bianchi et al., Florence, Italy. In Onco Targets Ther, 2013
In this study, we analyzed the value of topoisomerase II alpha (TOP2A) and transducin-like enhancer of split 3 (TLE3) as predictive markers of response to therapy with anthracyclines and taxanes.
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs.
Tontonoz et al., Los Angeles, United States. In Cell Metab, 2013
Here we show that TLE3 is a white-selective cofactor that acts reciprocally with the brown-selective cofactor Prdm16 to specify lipid storage and thermogenic gene programs.
The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation.
Zaret et al., Philadelphia, United States. In Development, 2012
Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and beta-cell differentiation
TLE3 expression is associated with sensitivity to taxane treatment in ovarian carcinoma.
Huh et al., Sydney, Australia. In Cancer Epidemiol Biomarkers Prev, 2012
High TLE3 expression predicts a favorable response to taxane containing chemotherapy regimens in ovarian carcinoma.
Angiosarcoma: a study of 98 cases with immunohistochemical evaluation of TLE3, a recently described marker of potential taxane responsiveness.
Folpe et al., Rochester, United States. In J Cutan Pathol, 2011
A lack of TLE3 expression in cutaneous angiosarcoma may reflect differing pathogenesis.
TLE3 is a dual-function transcriptional coregulator of adipogenesis.
Tontonoz et al., Los Angeles, United States. In Cell Metab, 2011
TLE3 acts as a dual-function switch, driving the formation of both active and repressive transcriptional complexes that facilitate the adipogenic program.
Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.
Camper et al., Ann Arbor, United States. In Mol Endocrinol, 2010
Studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1.
Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance.
Dorssers et al., Rotterdam, Netherlands. In J Clin Oncol, 2009
PATIENTS AND METHODS: mRNA levels of 10 BCAR genes (AKT1, AKT2, BCAR1, BCAR3, EGFR, ERBB2, GRB7, SRC, TLE3, and TRERF1) were measured in estrogen receptor-positive breast tumors using quantitative reverse-transcriptase polymerase chain reaction.
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