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Transglutaminase 2, C polypeptide

tissue-type transglutaminase
catalyzes acyl transferase reaction of gamma-carboxamide groups of glutamine residues (donor peptide) with epsilon-amino groups of lysine residues (acceptor peptide) [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Transglutaminase, ACID, CAN, SDSL, tissue transglutaminase
Papers on tissue-type transglutaminase
Lipopolysaccharide-Stimulated Transglutaminase 2 Expression Enhances Endocytosis Activity in the Mouse Microglial Cell Line BV-2.
Nakamura et al., Ōsaka, Japan. In Neuroimmunomodulation, 2014
OBJECTIVES: In peripheral macrophages, tissue-type transglutaminase (TG2) is reported to be involved in phagocytosis of apoptotic cells.
Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation.
Ratan et al., White Plains, United States. In J Neurosci, 2012
Forced expression of TG1 or TG2 proteins is sufficient to induce neuronal death in Rattus norvegicus cortical neurons in vitro.
Expression of tissue transglutaminase on primary olfactory ensheathing cells cultures exposed to stress conditions.
Pellitteri et al., Catania, Italy. In Neurosci Res, 2012
Our results show an increase in TG2 expression in olfactory ensheathing cells owing to glutamate or LPS treatment.
Iron enhances the neurotoxicity of amyloid β.
Hua et al., Ann Arbor, United States. In Transl Stroke Res, 2012
DNA damage, neuronal death and tissue-type transglutaminase (tTG) expression were also examined.
Transglutaminase 2-mediated activation of β-catenin signaling has a critical role in warfarin-induced vascular calcification.
Nurminskaya et al., Baltimore, United States. In Arterioscler Thromb Vasc Biol, 2012
Warfarin-induced calcification in A10 vascular smooth muscle cells is associated with the activation of beta-catenin signaling. Vascular cells with genetically or pharmacologically reduced TG2 activity fail to activate beta-catenin in response to warfarin.
Expression of the integrin coreceptor transglutaminase-2 in the RPE in vivo and in culture.
Finnemann et al., United States. In Adv Exp Med Biol, 2011
TGM2 may play a role in the alphavbeta5 integrin dependent phagocytosis of retinal outer segments by retinal pigment epithlial cells.
Screening of substrate peptide sequences for tissue-type transglutaminase (TGase 2) using T7 phage cDNA library.
Hitomi et al., Nagoya, Japan. In Cytotechnology, 2011
In this study, we have established a novel screening system that enables identification of cDNA sequence encoding favorable primary structure as a substrate for tissue-type transglutaminase (TGase 2), a multifunctional and ubiquitously expressing isozyme.
Tgm2/Gh, Gbx1 and TGF-beta are involved in retinoic acid-induced transdifferentiation from epidermis to mucosal epithelium.
Akimoto et al., Japan. In Int J Dev Biol, 2010
Tgm2/Gh, Gbx1 and TGF-beta are involved in retinoic acid-induced transdifferentiation from epidermis to mucosal epithelium
Red blood cell lysis and brain tissue-type transglutaminase upregulation in a hippocampal model of intracerebral hemorrhage.
Hua et al., Ann Arbor, United States. In Acta Neurochir Suppl (wien), 2010
Tissue-type transglutaminase (tTG), which has a role in neurodegeneration, is upregulated after ICH.
Role of transglutaminases in cuff-induced atherosclerotic lesion formation in femoral arteries of ApoE3 Leiden mice.
Bakker et al., Amsterdam, Netherlands. In Atherosclerosis, 2010
In this study we investigate the influence of combined inhibition of both tissue-type transglutaminase (TG2) and the plasma transglutaminase FXIIIA on early lesion development.
Calcification locates to transglutaminases in advanced human atherosclerotic lesions.
Bakker et al., Amsterdam, Netherlands. In Am J Pathol, 2009
Sections of the carotid artery specimens were registered to micro-computed tomography images and stained for tissue-type transglutaminase, plasma transglutaminase factor XIIIA (FXIIIA), the N(epsilon)(gamma-glutamyl)lysine cross-link, and the macrophage marker CD68.
Involvement of tissue transglutaminase in endothelin 1-induced hypertrophy in cultured neonatal rat cardiomyocytes.
Zheng et al., Beijing, China. In Hypertension, 2009
Tissue-type transglutaminase (tTG) may act as a positive regulator of the hypertrophic program in response to ET-1. This is attributable to signaling activity of tTG rather than transglutaminase activity.
Expression of tissue-type transglutaminase (tTG) and the effect of tTG inhibitor on the hippocampal CA1 region after transient ischemia in gerbils.
Seong et al., Seoul, South Korea. In Brain Res, 2009
Chronological changes of tissue-type transglutaminase (tTG) were observed in the hippocampal CA1 region after transient forebrain ischemia in gerbils.
Biological and therapeutic significance of tissue transglutaminase in pancreatic cancer.
Mehta, Houston, United States. In Amino Acids, 2009
This article discusses the significance of tissue-type transglutaminase (TG2) whose expression is elevated in the majority of PDA tumors and cell lines.
Tissue-type transglutaminase and the effects of cystamine on intracerebral hemorrhage-induced brain edema and neurological deficits.
Hua et al., Ann Arbor, United States. In Brain Res, 2009
Neurodegeneration occurs after intracerebral hemorrhage (ICH) and tissue-type transglutaminase (tTG) has a role in neurodegenerative disorders.
Small artery remodeling and erythrocyte deformability in L-NAME-induced hypertension: role of transglutaminases.
VanBavel et al., Amsterdam, Netherlands. In J Vasc Res, 2007
METHODS AND RESULTS: Wild-type (WT) mice and tissue-type transglutaminase (tTG) knockout (KO) mice received the nitric oxide inhibitor Nomega-nitro-L-arginine methyl ester hydrochloride (L-NAME) to induce hypertension.
Transglutaminase-mediated activation of nuclear transcription factor-kappaB in cancer cells: a new therapeutic opportunity.
Mehta et al., Houston, United States. In Curr Cancer Drug Targets, 2007
Like NF-kappaB, tissue-type transglutaminase (TG2), the most diverse and ubiquitous member of the calcium-dependent transglutaminase family of enzymes, is also aberrantly overexpressed in many human cancer types, blocks apoptosis, and promotes drug resistance and metastatic phenotypes.
Flow-dependent remodeling of small arteries in mice deficient for tissue-type transglutaminase: possible compensation by macrophage-derived factor XIII.
VanBavel et al., Amsterdam, Netherlands. In Circ Res, 2006
We hypothesized that this remodeling depends on the crosslinking enzyme tissue-type transglutaminase (tTG).
Characterization of purified rat testicular transglutaminase and age-dependent changes of the enzyme activities.
Tsai et al., Taipei, Taiwan. In Int J Biochem Cell Biol, 2005
In conclusion, the purified testicular transglutaminase displays property of either the tissue-type transglutaminase, or the GTP-binding and hydrolyzing characteristics.
Small artery remodeling depends on tissue-type transglutaminase.
Vanbavel et al., Amsterdam, Netherlands. In Circ Res, 2005
Small artery remodeling associated with chronic vasoconstriction depends on tissue-type transglutaminase.
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