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Tripartite motif containing 28

TIF1beta, KAP1, TIF-IB, TRIM28
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CAN, V1a, POLYMERASE, Atm
Papers using TIF1beta antibodies
Reading and function of a histone code involved in targeting corepressor complexes for repression.
Xie Jingwu, In PLoS ONE, 2004
... The commercial antibodies used were H3, acH3, acH4, H3R17me2a and TIF1β/KAP1 from Abcam (Cambridge, MA, USA); HA ...
Papers on TIF1beta
Identification of cell-specific targets of sumoylation during mouse spermatogenesis.
Vigodner et al., Charlottesville, United States. In Reproduction, Feb 2016
Furthermore, several proteins that were previously identified as SUMO targets in somatic cells (KAP1 and MDC1) were identified as SUMO targets in germ cells.
RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner.
Ann et al., Duarte, United States. In Cell Cycle, Feb 2016
UNASSIGNED: Both RNF4 and KAP1 play critical roles in the response to DNA double-strand breaks (DSBs), but the functional interplay of RNF4 and KAP1 in regulating DNA damage response remains unclear.
Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks.
Trono, Lausanne, Switzerland. In Cold Spring Harb Symp Quant Biol, Feb 2016
We further showed that KRAB-ZFPs and their cofactor KAP1 exert a marked influence on the transcription dynamics of embryonic stem cells via their docking of repressor complexes at TE-contained regulatory sequences.
Erase-Maintain-Establish: Natural Reprogramming of the Mammalian Epigenome.
Solter et al., Singapore, Singapore. In Cold Spring Harb Symp Quant Biol, Feb 2016
This enigmatic process of natural epigenomic reprogramming is now being dissected in vivo, focusing on specific genomic regions-that is, imprinted genes and retrotransposons, where TRIM28 molecular complexes appear to guide the transition from gamete to embryo.
KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.
D'Orso et al., Dallas, United States. In Mol Cell, Feb 2016
Here we report that the transcriptional regulator KAP1 continuously tethers the 7SK snRNP to PRG promoters to facilitate P-TEFb recruitment and productive elongation in response to stimulation.
Systematic identification of factors for provirus silencing in embryonic stem cells.
Loh et al., Singapore, Singapore. In Cell, Oct 2015
Histone chaperones (Chaf1a/b), sumoylation factors (Sumo2/Ube2i/Sae1/Uba2/Senp6), and chromatin modifiers (Trim28/Eset/Atf7ip) are key determinants that establish provirus silencing.
Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells.
Banaszynski et al., Cambridge, United Kingdom. In Nature, Jul 2015
Recent studies have demonstrated that a subset of transposable elements, endogenous retroviral elements (ERVs) containing long terminal repeats (LTRs), are silenced through trimethylation of histone H3 on lysine 9 (H3K9me3) by ESET (also known as SETDB1 or KMT1E) and a co-repressor complex containing KRAB-associated protein 1 (KAP1; also known as TRIM28) in mouse embryonic stem cells.
Degradation of AMPK by a cancer-specific ubiquitin ligase.
Potts et al., Dallas, United States. In Cell, Mar 2015
Here, we describe a widespread mechanism to suppress AMPK through its ubiquitination and degradation by the cancer-specific MAGE-A3/6-TRIM28 ubiquitin ligase.
An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons.
Haussler et al., Santa Cruz, United States. In Nature, 2015
In mouse embryonic stem cells, transcriptional silencing of retrotransposons requires KAP1 (also known as TRIM28) and its repressive complex, which can be recruited to target sites by KRAB zinc-finger (KZNF) proteins such as murine-specific ZFP809 which binds to integrated murine leukaemia virus DNA elements and recruits KAP1 to repress them.
Transcriptional elongation requires DNA break-induced signalling.
Calderwood et al., Boston, United States. In Nat Commun, 2014
We have previously shown that RNA polymerase II (Pol II) pause release and transcriptional elongation involve phosphorylation of the factor TRIM28 by the DNA damage response (DDR) kinases ATM and DNA-PK.
Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family.
Macfarlan et al., Bethesda, United States. In Mob Dna, 2014
In tetrapods, a large proportion of tandem-ZFPs contain Krüppel-associated-box (KRAB) repression domains, which are able to induce epigenetic silencing through the KAP1 corepressor.
TRIM28 as a novel transcriptional elongation factor.
Calderwood et al., Boston, United States. In Bmc Mol Biol, 2014
TRIM28 is a multidomain protein with versatile functions in transcription and DNA repair.
Autophagy as a regulatory component of erythropoiesis.
An et al., Changsha, China. In Int J Mol Sci, 2014
Here, the modulators of autophagy that regulate erythroid differentiation were summarized, including autophagy-related (Atg) genes, the B-cell lymphoma 2 (Bcl-2) family member Bcl-2/adenovirus E1B 19 kDa interacting protein 3-like (Nix/Binp3L), transcription factors globin transcription factor 1 (GATA1) and forkhead box O3 (FoxO3), intermediary factor KRAB-associated protein1 (KAP1), and other modulators, such as focal adhesion kinase family-interacting protein of 200-kDa (FIP200), Ca2+ and 15-lipoxygenase.
Expression of KAP1 in epithelial ovarian cancer and its correlation with drug-resistance.
Sun et al., Tianjin, China. In Int J Clin Exp Med, 2014
KAP1 is a universal corepressor for Kruppel-associated box zinc finger proteins.
A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy.
Trono et al., Lausanne, Switzerland. In Science, 2013
We explored the role of KRAB-containing zinc finger proteins (KRAB-ZFPs) and their cofactor KAP1 in this process.
Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin.
Khanna et al., Brisbane, Australia. In J Biol Chem, 2012
a novel mechanism of KAP-1-mediated chromatin restructuring via Chk2-regulated HP1-beta exchange from heterochromatin, promoting DNA repair.
Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response.
Wang et al., Shanghai, China. In J Biol Chem, 2012
KAP1 Ser-473 phosphorylation was required for efficient DNA repair and cell survival in response to DNA damage.
TRIM28 prevents autoinflammatory T cell development in vivo.
Honjo et al., Kyoto, Japan. In Nat Immunol, 2012
TRIM28 regulates t-cell homeostasis and also interacts with pathways involved in the differentiation of Foxp3+ T cells amd TH17 cells.
KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function.
Trono et al., Lausanne, Switzerland. In Blood, 2012
The role of KRAB/KAP1-mediated epigenetic regulation in B-cell development and homeostasis.
Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response.
Chowdhury et al., Boston, United States. In Embo J, 2012
The authors devised a novel proteomic strategy for systematic identification of proteins dephosphorylated by PP4C and identified KRAB-domain-associated protein 1 (KAP-1) as a substrate.
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