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Tyrosine kinase with immunoglobulin-like and EGF-like domains 1

This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: TIE-2, vascular endothelial growth factor, CAN, KDR, Angpt1
Papers on Tie-1
Receptor tyrosine kinase gene expression profiles of Ewing sarcomas reveal ROR1 as a potential therapeutic target in metastatic disease.
Dirksen et al., Münster, Germany. In Mol Oncol, Jan 2016
Among them, VEGFR3 and TIE1 showed high-level expressions and also were suggestive of poor prognosis in localized tumors; underscoring the relevance of angiogenic signaling pathways and tumor-stroma interactions in Ewing sarcoma.
Lipid remodeling in Rhodopseudomonas palustris TIE-1 upon loss of hopanoids and hopanoid methylation.
Newman et al., Pasadena, United States. In Geobiology, Sep 2015
We compare lipidomes of the metabolically versatile α-proteobacterium Rhodopseudomonas palustris TIE-1 and two hopanoid mutants, detecting native hopanoids simultaneously with other types of polar lipids by electrospray ionization mass spectrometry.
Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial.
Van Cutsem et al., Barcelona, Spain. In Lancet Oncol, Aug 2015
We also measured the concentration of 15 proteins of interest-angiopoietin 2, interleukin 6, interleukin 8, placental growth factor, soluble TIE-1, soluble VEGFR1, VEGF-A, VEGF-C, VEGF-D, VEGF-A isoform 121, bone morphogenetic protein 7, macrophage colony-stimulating factor, stromal cell-derived factor-1, tissue inhibitor of metalloproteinase 2, and von Willebrand factor-in plasma samples from 611 patients.
Quantitative hopanoid analysis enables robust pattern detection and comparison between laboratories.
Newman et al., Pasadena, United States. In Geobiology, Jul 2015
We optimized 2-methylhopanoid production in Rhodopseudomonas palustris TIE-1 and purified 2Me-diplopterol, 2Me-bacteriohopanetetrol (2Me-BHT), and their unmethylated species (diplopterol and BHT).
Identification and expression analysis of 26 oncogenes of the receptor tyrosine kinase family in channel catfish after bacterial infection and hypoxic stress.
Liu et al., Auburn, United States. In Comp Biochem Physiol Part D Genomics Proteomics, Jun 2015
The 26 RTK genes were divided into four subfamilies according to phylogenetic analysis, including TIE (2 genes), ErbB (6 genes), EPH (14 genes), and INSR (4 genes).
Redox cycling of Fe(II) and Fe(III) in magnetite by Fe-metabolizing bacteria.
Kappler et al., Tübingen, Germany. In Science, Apr 2015
We show through magnetic and spectroscopic measurements that the phototrophic Fe(II)-oxidizing bacterium Rhodopseudomonas palustris TIE-1 oxidizes magnetite (Fe3O4) nanoparticles using light energy.
Methylation at the C-2 position of hopanoids increases rigidity in native bacterial membranes.
Newman et al., Pasadena, United States. In Elife, 2014
To gain insight into the meaning of 2-methylhopanes, we quantified the dominant (des)methylated hopanoid species in the membranes of the model hopanoid-producing bacterium Rhodopseudomonas palustris TIE-1.
Obesity and heterozygous endothelial overexpression of prepro-endothelin-1 modulate responsiveness of mouse main and segmental renal arteries to vasoconstrictor agents.
Vanhoutte et al., Hong Kong, Hong Kong. In Life Sci, 2014
MAIN METHODS: Mice with tie-1 promoter-driven endothelium-restricted heterozygous overexpression of preproendothelin-1 were used (TET(het)).
Electron uptake by iron-oxidizing phototrophic bacteria.
Girguis et al., Cambridge, United States. In Nat Commun, 2013
Here we show that the iron-oxidizing photoautotroph Rhodopseudomonas palustris TIE-1 accepts electrons from a poised electrode, with carbon dioxide as the sole carbon source/electron acceptor.
Transgenesis and imaging in birds, and available transgenic reporter lines.
Lansford et al., Kumamoto, Japan. In Dev Growth Differ, 2013
To study mechanisms of blood vessel formation and remodeling in developing embryos by using a time-lapse imaging approach, a transgenic quail model, Tg(tie1:H2B-eYFP), was generated.
Tie1 deficiency induces endothelial-mesenchymal transition.
Tournaire et al., Marseille, France. In Embo Rep, 2012
Data propose that EndMT associated with Tie1 downregulation participates in the pathological development of stroma observed in tumours.
Tie1 regulates the Tie2 agonistic role of angiopoietin-2 in human lymphatic endothelial cells.
Suh et al., Suwŏn, South Korea. In Biochem Biophys Res Commun, 2012
these results suggest that the expression level of Tie1 and its physical interaction with Tie2 defines whether Ang2 functions as a Tie2 agonist or antagonist, thereby determining the context-dependent differential endothelial sensitivity to Ang2.
The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling.
Brindle et al., Leicester, United Kingdom. In Plos One, 2011
the effects of factors activating ectodomain cleavage on both Tie1 and Tie2 within the same population of cells, and their impact on angiopoietin signalling
Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner.
Baldwin et al., Nashville, United States. In J Clin Invest, 2011
Shear stress conditions that modulate atherogenic events also regulate Tie1 expression. Therefore, Tie1 may play a novel proinflammatory role in atherosclerosis.
Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity.
Schulte-Merker et al., Utrecht, Netherlands. In Dis Model Mech, 2011
Tie-1 and Tie-2 are not required for early heart development, yet they have redundant roles for the maintenance of endocardial-myocardial connection in later stages.
Kinases as drug discovery targets in hematologic malignancies.
Hannah, In Curr Mol Med, 2005
Certain kinases have been validated as targets for drug discovery in hematological malignancies (such as BCR-ABL and FLT3); other novel kinases hold considerable interest for targeted intervention: myeloid leukemias (KDR, KIT, CSF-1R, RAS and RAF), lymphoid leukemias (JAK2 fusion protein, TIE-1, CDK modulators), lymphoma (ALK, CDK modulators, mTOR), myeloproliferative disorders (PDGF-R or FGF-R fusion gene products, FGF-R1) and myeloma (FGF-R3, STAT3).
Remodeling of the microenvironment by aggressive melanoma tumor cells.
Seftor et al., Iowa City, United States. In Ann N Y Acad Sci, 2003
Based on the recent characterization of vasculogenic mimicry by aggressive melanoma cells, particularly their ability to express VE (vascular endothelial)-cadherin, TIE-1, and EphA2, current studies have focused on the molecular signals deposited by these cells as they remodel their microenvironment.
Tyrosine kinases and gastric cancer.
Chen et al., Taipei, Taiwan. In Oncogene, 2000
Two new gastric cancer molecular markers (tie-1 and mkk4) have been identified through the use of these profiles and demonstrated effective as clinical prognostic indicators.
Differentiation of blood-brain barrier endothelial cells.
Engelhardt et al., Bad Nauheim, Germany. In Pathol Biol (paris), 1998
VEGF receptors 1 and 2 (flt-1 and flk-1) as well as the recently identified angiopoietin receptors (tie-1 and tie-2) are receptor tyrosine kinases specifically expressed in endothelial cells.
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.
Yancopoulos et al., New York City, United States. In Cell, 1997
Only one other family of receptor tyrosine kinases, comprising TIE1 and TIE2, is largely endothelial cell specific.
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