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STEAP family member 4

The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011] (from NCBI)
Top mentioned proteins: Insulin, STEAP, CAN, fibrillin-1, Interleukin-6
Papers on TIARP
Genetic Variants in Six-Transmembrane Epithelial Antigen of Prostate 4 Increase Risk of Developing Metabolic Syndrome in a Han Chinese Population.
Kou et al., Changchun, China. In Genet Test Mol Biomarkers, Dec 2015
BACKGROUND: Altered expression of six-transmembrane epithelial antigen of prostate 4 (STEAP4) is linked to obesity, insulin insensitivity, metabolic homeostasis, and inflammation.
Vitamin A supplementation enhances Senegalese sole (Solea senegalensis) early juvenile's immunocompetence: New insights on potential underlying pathways.
Gisbert et al., Faro, Portugal. In Fish Shellfish Immunol, Oct 2015
damselae, survival rate, as well as underlying gene expression of specific immune markers (C1inh, C3, C9, Lgals1, Hamp, LysC, Prdx1, Steap4 and Transf) were evaluated.
A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis.
Li et al., Shanghai, China. In J Exp Med, Oct 2015
Although this axis dictates the expression of target genes Steap4 (a metalloreductase for cell metabolism and proliferation) and p63 (a transcription factor for epidermal stem cell proliferation), Steap4 is required for the IL-17-induced sustained expansion of p63(+) basal cells in the epidermis.
Characterization of a single b-type heme, FAD, and metal binding sites in the transmembrane domain of six-transmembrane epithelial antigen of the prostate (STEAP) family proteins.
Lawrence et al., Bozeman, United States. In J Biol Chem, Oct 2015
Although the cytoplasmic N-terminal oxidoreductase domain of Steap3 and Steap4 are relatively well characterized, little work has been done to characterize the transmembrane domain of any member of the Steap family.
An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes.
Nunemaker et al., Torrance, United States. In Endocrinology, Sep 2015
and Steap4 (7q21.12).
Steap4 attenuates high glucose and S100B-induced effects in mesangial cells.
Chuang et al., Kao-hsiung, Taiwan. In J Cell Mol Med, Jun 2015
Six-transmembrane epithelial antigen of prostate 4 (Steap4)-knockout mice develop hyperglycaemia and inflammation whereas Steap4 overexpression attenuates atherosclerosis in diabetic mice.
Right ventricular myocardial biomarkers in human heart failure.
Hemnes et al., Taipei, Taiwan. In J Card Fail, May 2015
In an unbiased approach, the top 10 DEGs SERPINA3, SERPINA5, LCN6, LCN10, STEAP4, AKR1C1, STAC2, SPARCL1, VSIG4 and F8 exhibited no overlap in read counts between DON and HF RVs, high sensitivities, specificities, predictive values and areas under the receiver operating characteristic curves.
Poly(ADP-ribose) in the bone: from oxidative stress signal to structural element.
Virág et al., Debrecen, Hungary. In Free Radic Biol Med, May 2015
In the past decades numerous studies demonstrating production of reactive oxygen or nitrogen intermediates, effects of different antioxidants, and involvement of prototypical redox control mechanisms (Nrf2-Keap1, Steap4, FoxO, PAMM, caspase-2) have proven the central role of redox regulation in the bone.
STAMP2 increases oxidative stress and is critical for prostate cancer.
Saatcioglu et al., Oslo, Norway. In Embo Mol Med, Mar 2015
The six transmembrane protein of prostate 2 (STAMP2) is an androgen-regulated gene whose mRNA expression is increased in prostate cancer (PCa).
STEAP4 and insulin resistance.
Zhao et al., Chengdu, China. In Endocrine, 2014
STEAP4 is a novel anti-obesity gene that is significantly down-regulated in adipose tissue of obese patients.
STAMPing into Mitochondria.
Kim et al., Pusan, South Korea. In Int J Biol Sci, 2013
Six transmembrane protein of prostate 2 (STAMP2) is a protein that has been extensively studied due to its association with prostate cancer.
Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis.
Hotamisligil et al., Boston, United States. In Cell Metab, 2012
Stamp2 is detected in mouse and human atherosclerotic plaques, and its deficiency promotes atherosclerosis in mice.
STEAP proteins: from structure to applications in cancer therapy.
Santos et al., Covilhã, Portugal. In Mol Cancer Res, 2012
The human 6-transmembrane epithelial antigen of prostate (STEAP) family comprises STEAP1, STEAP2, STEAP3, and STEAP4.
Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis.
Sumida et al., Tsukuba, Japan. In Mod Rheumatol, 2012
STEAP4 might potentially suppress the pathogenesis of TNFalpha-induced arthritis such as rheumatoid arthritis.
Six-transmembrane epithelial antigen of prostate 4 (STEAP4) is expressed on monocytes/neutrophils, and is regulated by TNF antagonist in patients with rheumatoid arthritis.
Sumida et al., Tsukuba, Japan. In Clin Exp Rheumatol, 2012
STEAP4 is expressed on monocytes and neutrophils in peripheral blood of patients with rheumatoid arthritis.
[Crucial role of TNFα-induced adipose-related protein (TIARP) in the pathogenesis of autoimmune arthritis].
Sumida et al., Tsukuba, Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2011
STEAP4 (the human ortholog of TIARP) was highly upregulated in joints of patients with RA and especially co-localized with CD68(+) macrophages.
Decreased STAMP2 expression in association with visceral adipose tissue dysfunction.
Fernández-Real et al., Girona, Spain. In J Clin Endocrinol Metab, 2011
Decreased STAMP2 expression (mRNA and protein) might reflect visceral adipose dysfunction in subjects with obesity and type 2 diabetes.
A common variation within the STEAP4 gene exons is associated with obesity in Uygur general population.
Luo et al., Ürümqi, China. In Chin Med J (engl), 2011
an association of the common variation rs1981529 (Gly75Asp, 224A/G) in the STEAP4 gene with obesity in Uygur general population
Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis.
Hotamisligil et al., Boston, United States. In Cell, 2007
Study concludes that STAMP2 participates in integrating inflammatory and metabolic responses and thus plays a key role in systemic metabolic homeostasis.
STAMPing out Inflammation.
Tontonoz et al., Los Angeles, United States. In Cell, 2007
In this issue, Wellen et al. (2007) identify STAMP2 as a factor that integrates inflammatory and nutritional signals with metabolism.
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