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TIA1 cytotoxic granule-associated RNA binding protein-like 1

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TIA, CAN, ACID, HAD, V1a
Papers using TIAR antibodies
Induction of neurites by the regulatory domain of PKCδ and ε in neural cells is counteracted by PKC catalytic activity and the RhoA pathway.
Kahle Philipp J., In PLoS ONE, 2003
... GST, IGF2BP3, PABPC1, TIA1/TIAR (H-120), TIAR(C-18), HRI (S-16), and PKCα (antigen in C-terminus) antibodies were obtained from Santa Cruz, PKCα rabbit monoclonal antibody (antigen in N-terminus) from Epitomics, TIA1 and PKR from ...
Papers on TIAR
Suppression of antigen-specific antibody responses in mice exposed to perfluorooctanoic acid: Role of PPARα and T- and B-cell targeting.
Luebke et al., Greenville, United States. In J Immunotoxicol, Jan 2016
To determine if suppression of humoral immunity by PFOA is peroxisome proliferator activated receptor alpha (PPARα)-dependent and if suppression is associated with specific targeting of T- or B-cells, three separate experiments were conducted: (1) female PPARα constitutive knockout (PPARα KO; B6.129S4-Ppar(tm1Gonz)N12) and wild-type controls (WT; C57BL/6-Tac) exposed to 0, 7.5, or 30 mg PFOA/kg for 15 days were immunized on Day 11 with a T-cell-dependent antigen and sera then collected for measures of antigen-specific IgM titers (TDAR) 5 days later; (2) female C57BL/6N WT mice exposed to 0, 0.94, 1.88, 3.75, or 7.5 mg PFOA/kg for 15 days were immunized with a T-cell-independent antigen on Day 11 and sera were then collected for analyses of antigen-specific IgM titers (TIAR) 7 days later; and (3) splenic lymphocyte phenotypes were assessed in unimmunized female C57BL/6N WT mice exposed to 0, 3.75, or 7.5 mg PFOA/kg for 10 days to investigate effects of PFOA in the absence of specific immunization.
TIA-1 and TIAR interact with 5'-UTR of enterovirus 71 genome and facilitate viral replication.
Wu et al., Nanjing, China. In Biochem Biophys Res Commun, Nov 2015
Here, we found that T-cell-restricted intracellular antigen 1 (TIA-1), and TIA-1 related protein (TIAR) were translocated from nucleus to cytoplasm after EV71 infection and localized to the sites of viral replication.
Genome-wide analysis of alternative transcripts in human breast cancer.
Cai et al., Coral Gables, United States. In Breast Cancer Res Treat, Jun 2015
We uncovered nine splicing factors (FOX2, MBNL1, QKI, PTBP1, ELAVL1, HNRNPC, KHDRBS1, SFRS2, and TIAR) that were involved in aberrant splicing in breast cancer.
Stress granules are dispensable for mRNA stabilization during cellular stress.
Hüttelmaier et al., Halle, Germany. In Nucleic Acids Res, Mar 2015
Here, we demonstrate that the sustained inhibition of visible SGs requires the concomitant knockdown of TIA1, TIAR and G3BP1.
An ShRNA Based Genetic Screen Identified Sesn2 as a Potential Tumor Suppressor in Lung Cancer via Suppression of Akt-mTOR-p70S6K Signaling.
Zhou et al., Harbin, China. In Plos One, 2014
A total of 6 candidate transformation suppressors including INPP4B, Sesn2, TIAR, ACRC, Nup210, LMTK3 were identified.
T-cell intracellular antigens in health and disease.
Izquierdo et al., Madrid, Spain. In Cell Cycle, 2014
T-cell intracellular antigen 1 (TIA1) and TIA1-related/like protein (TIAR/TIAL1) are 2 proteins discovered in 1991 as components of cytotoxic T lymphocyte granules.
T-cell intracellular antigens function as tumor suppressor genes.
Izquierdo et al., Madrid, Spain. In Cell Death Dis, 2014
Knockdown of T-cell intracellular antigens TIA1 and TIAR in transformed cells triggers cell proliferation and tumor growth.
Targeted Knockdown of RNA-Binding Protein TIAR for Promoting Self-Renewal and Attenuating Differentiation of Mouse Embryonic Stem Cells.
Song et al., Shanghai, China. In Stem Cells Int, 2014
RNA-binding protein TIAR has been suggested to mediate the translational silencing of ARE-containing mRNAs.
Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation.
Piwocka et al., Warsaw, Poland. In Cell Cycle, 2013
We investigated 2 mRNA-binding proteins - HuR and TIAR showing specificity to AU-Rich Element (ARE) sites in 3'UTR of mRNA.
Long-term reduction of T-cell intracellular antigens reveals a transcriptome associated with extracellular matrix and cell adhesion components.
Izquierdo et al., Madrid, Spain. In Plos One, 2013
Knockdown of T-cell intracellular antigens TIA1 and TIAR contributes to a cellular phenotype characterised by uncontrolled proliferation and tumorigenesis.
RNA recognition and stress granule formation by TIA proteins.
Wilce et al., Australia. In Int J Mol Sci, 2013
Fundamental to SG formation are the T cell restricted intracellular antigen (TIA) proteins (TIA-1 and TIA-1 related protein (TIAR)), that both directly bind to target RNA and self-associate to seed the formation of SGs.
Alternative splicing of the neurofibromatosis type I pre-mRNA.
Lou et al., Cleveland, United States. In Biosci Rep, 2012
Exon 23a inclusion is tightly regulated by at least three different families of RNA-binding proteins: CELF {CUG-BP (cytosine-uridine-guanine-binding protein) and ETR-3 [ELAV (embryonic lethal abnormal vision)-type RNA-binding protein]-like factor}, Hu and TIA-1 (T-cell intracellular antigen 1)/TIAR (T-cell intracellular antigen 1-related protein).
A new concept of endometriosis and adenomyosis: tissue injury and repair (TIAR).
Wildt et al., In Horm Mol Biol Clin Investig, 2011
Pelvic endometriosis, deeply infiltrating endometriosis and uterine adenomyosis share a common pathophysiology and may be integrated into the physiological mechanism and new nosological concept of 'tissue injury and repair' (TIAR) and may, in this context, just represent the extreme of a basically physiological, estrogen-related mechanism that is pathologically exaggerated in an extremely estrogen-sensitive reproductive organ.
TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy.
Singh et al., Ames, United States. In Mol Cell Biol, 2011
TIA1 and TIAR proteins are intron-associated positive regulators of SMN2 exon 7 splicing.
TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions of rapid oxygen decline and extreme hypoxia and suppress the HIF-1α pathway.
Hänze et al., Gießen, Germany. In J Mol Cell Biol, 2010
Severe hypoxia caused co-aggregation of TIAR/TIA-1 and these proteins suppressed HIF-1alpha expression.
Mechanisms of TNFα regulation in uveitis: focus on RNA-binding proteins.
Nicholson et al., Bristol, United Kingdom. In Prog Retin Eye Res, 2010
These include tristetraprolin (TTP), T cell antigen-1 (TIA-1), TIA-1-related protein (TIAR), human antigen R (HuR) and fragile-X-related protein 1 (FXR1).
Identification of chosen apoptotic (TIAR and TIA-1) markers expression in thyroid tissues from adolescents with immune and non-immune thyroid diseases.
Bossowska et al., Białystok, Poland. In Folia Histochem Cytobiol, 2010
Data show that apoptotic (TIAR and TIA-1) marker expression in thyroid tissues from adolescents with immune thyroid diseases is higher than in non-immune thyroid diseases.
Impaired embryonic development in mice overexpressing the RNA-binding protein TIAR.
Morello et al., Brussels, Belgium. In Plos One, 2009
study reports the importance of the tightly balanced expression of the RNA-binding protein TIAR for normal embryonic development, thereby emphasizing the role of post-transcriptional regulations in early embryonic programming
iCLIP predicts the dual splicing effects of TIA-RNA interactions.
Ule et al., Cambridge, United Kingdom. In Plos Biol, 2009
Data show that TIA1 and TIAL1 bind at the same positions on human RNAs, and are consistent with a model where TIA proteins shorten the time available for definition of an alternative exon by enhancing recognition of the preceding 5' splice site.
[Aberrant regulation of mRNA 3' untranslated region in cancers and inflammation].
Morello et al., Toulouse, France. In Med Sci (paris), 2008
For instance, HuR/ELAV is mainly known to protect ARE-containing mRNAs from degradation, while AUF1, TTP and KSRP act to destabilize their bound target mRNAs and TIA/TIAR to inhibit their translation.
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