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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

T cell lymphoma invasion and metastasis 1

Top mentioned proteins: Akt, Rac1, Rhodopsin, miR, Actin
Papers using Tiam1 antibodies
Class 1A PI3K regulates vessel integrity during development and tumorigenesis
Ridley Anne J. et al., In The Journal of Cell Biology, 2007
... from Sigma-Aldrich; VE-cadherin, p120-catenin, and phospho–p120-catenin were obtained from BD; RhoA, -B, and -C and Tiam-1 were purchased from Santa Cruz Biotechnology, Inc.; Akt, pAktS473, pAktT308, ...
Requirement of ZO-1 for the formation of belt-like adherens junctions during epithelial cell polarization
Tsukita Shoichiro et al., In The Journal of Cell Biology, 1994
... Rabbit anti-aPKC pAb and anti-Tiam1 pAb were purchased from Santa Cruz Biotechnology, Inc ...
Papers on Tiam1
[Association of TIAM1 gene polymorphisms with Kawasaki disease and its clinical characteristics].
Wan et al., Xianning, China. In Zhongguo Dang Dai Er Ke Za Zhi, Nov 2015
OBJECTIVE: To investigate the association of single nucleotide polymorphisms (SNP) rs22833188 and rs2833195 in TIAM1 gene with the susceptibility to Kawasaki disease (KD) and its clinical characteristic in children.
[Expression and clinical significance of T lymphoma invasion and metastasis inducing factor 1 in oral squamous cell carcinoma].
Su et al., Changsha, China. In Shanghai Kou Qiang Yi Xue, Oct 2015
PURPOSE: T lymphoma invasion and metastasis inducing factor 1 (TIAM1) overexpression has been reported in a variety of human cancers.
By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth.
Feng et al., Beijing, China. In Oncotarget, Aug 2015
We identified T lymphoma invasion and metastasis 1 (TIAM1) gene as potential target of miR-329.
Genome-wide association pathway analysis to identify candidate single nucleotide polymorphisms and molecular pathways for gastric adenocarcinoma.
Sun et al., Nanjing, China. In Tumour Biol, Jul 2015
The most significant pathway was the regulation of the ephrin receptor binding pathway, which involved EFNA1, TIAM1, EFNA5, EFNB2, and EFNB3.
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.
Behrends et al., Frankfurt am Main, Germany. In Mol Cell, Apr 2015
Here, we identify a novel CUL3 RING ubiquitin ligase complex, containing the substrate adaptors KBTBD6 and KBTBD7, that mediates ubiquitylation and proteasomal degradation of TIAM1, a RAC1-specific GEF.
The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration.
Pruitt et al., Shreveport, United States. In Oncogene, Feb 2015
Here, we demonstrate that SIRT1 and SIRT2 positively regulate the levels of Rac1-GTP and the activity of T-cell lymphoma invasion and metastasis 1 (TIAM1), a Rac guanine nucleotide exchange factor (GEF).
HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.
Malliri et al., Manchester, United Kingdom. In Cell Rep, Feb 2015
Here, we uncover a role for HUWE1 in cell migration and invasion through degrading the RAC activator TIAM1, implying an additional function in malignant progression.
MicroRNA-377 suppresses cell proliferation and invasion by inhibiting TIAM1 expression in hepatocellular carcinoma.
Yuan et al., Harbin, China. In Plos One, 2014
Subsequent investigation revealed that T lymphoma invasion and metastasis 1 (TIAM1) was a direct and functional target of miR-377 in HCC cells.
The Downregulation of MiR-182 Is Associated with the Growth and Invasion of Osteosarcoma Cells through the Regulation of TIAM1 Expression.
Yuan et al., Changsha, China. In Plos One, 2014
Subsequent investigation revealed that TIAM1 was a direct and functional target of miR-182 in osteosarcoma cells.
TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy.
Mishra et al., Detroit, United States. In Diabetologia, 2014
In this study we assessed the role of T cell lymphoma invasion and metastasis (TIAM1), a guanine nucleotide exchange factor for RAC1, in RAC1 and NOX2 activation and the onset of mitochondrial dysfunction in in vitro and in vivo models of glucotoxicity and diabetes.
Landscape of the relationship between type 2 diabetes and coronary heart disease through an integrated gene network analysis.
Duan et al., Ningbo, China. In Gene, 2014
P=0.006), TIAM1 (T2D: OR=1, P=1; CAD: OR=1.48,
Genes-environment interactions in obesity- and diabetes-associated pancreatic cancer: a GWAS data analysis.
Li et al., Anderson, United States. In Cancer Epidemiol Biomarkers Prev, 2014
The major contributing genes to the two top pathways include GNGT2, RELA, TIAM1, and GNAS.
eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases.
Sessa et al., New Haven, United States. In J Cell Sci, 2014
The loss of NO increased the recruitment of the Rac guanine-nucleotide-exchange factor (GEF) TIAM1 to adherens junctions and VE-cadherin (also known as cadherin 5), and reduced Rho activation and stress fiber formation.
Tiam1, negatively regulated by miR-22, miR-183 and miR-31, is involved in migration, invasion and viability of ovarian cancer cells.
Lu et al., Shanghai, China. In Oncol Rep, 2012
Tiam1 may be involved in the aggressive behavior of ovarian cancer, and differential expression of microRNA may contribute to the dysregulation of Tiam1, which contributes to the invasive, migratory and viability properties of ovarian cancer cells
Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells.
Nakanishi et al., Suita, Japan. In Proc Natl Acad Sci U S A, 2012
Study shows that the NR2C and Tiam1 maturation genes are synergistically controlled by the activity-dependent induction of Etv1.
Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes.
Versteeg et al., Amsterdam, Netherlands. In Nature, 2012
In addition, ATRX, TIAM1 and a series of regulators of the Rac/Rho pathway were mutated, further implicating defects in neuritogenesis in neuroblastoma.
Expression of Tiam1 in lung cancer and its clinical significance.
Wang et al., Zhengzhou, China. In Asian Pac J Cancer Prev, 2011
High Tiam1 protein expression is associated with lung cancer development and metastasis.
Tiam1 is recruited to β1-integrin complexes by 14-3-3ζ where it mediates integrin-induced Rac1 activation and motility.
Fox et al., Cleveland, United States. In J Cell Physiol, 2011
These findings suggest a previously unrecognized mechanism of integrin-induced Rac1 activation in which 14-3-3 dimers localize Tiam1 to integrin complexes, where it mediates integrin-dependent Rac1 activation, thus initiating motility-inducing pathways.
TCR-induced activation of LFA-1 involves signaling through Tiam1.
Gahmberg et al., Helsinki, Finland. In J Immunol, 2011
activation through the T cell receptor results in phosphorylation of LFA-1 that leads to engagement of Tiam1 and Rac1
The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis.
Macara et al., Charlottesville, United States. In Nat Cell Biol, 2006
A balance of PAR-3 and TIAM1 is essential to modulate Rac-GTP levels and to allow spine morphogenesis.
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