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Thyrotropin-releasing hormone receptor

thyrotropin-releasing hormone receptor, TRH-R
This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: Thyrotropin-Releasing Hormone, ACID, V1a, HAD, CAN
Papers on thyrotropin-releasing hormone receptor
A Novel Thyrotropin-Releasing Hormone Receptor Missense Mutation (P81R) in Central Congenital Hypothyroidism.
Schoenmakers et al., Cambridge, United Kingdom. In J Clin Endocrinol Metab, Feb 2016
Recognised causes include TSH beta subunit (TSHB) and Immunoglobulin superfamily member 1 (IGSF1) mutations with only two previous reports of biallelic, highly disruptive mutations in the thyrotropin releasing hormone receptor (TRHR) gene.
Central Hypothyroidism in Miniature Schnauzers.
Kooistra et al., Utrecht, Netherlands. In J Vet Intern Med, Jan 2016
Additionally, the possible role of the thyroid-stimulating hormone (TSH)-releasing hormone receptor (TRHR) gene and the TSHβ (TSHB) gene was investigated.
DEHP reduces thyroid hormones via interacting with hormone synthesis-related proteins, deiodinases, transthyretin, receptors, and hepatic enzymes in rats.
Li et al., Chongqing, China. In Environ Sci Pollut Res Int, Aug 2015
TSH receptor (TSHr) level was downregulated, while TRH receptor (TRHr) level was upregulated.
TRH-receptor mobility and function in intact and cholesterol-depleted plasma membrane of HEK293 cells stably expressing TRH-R-eGFP.
Svoboda et al., Praha, Czech Republic. In Biochim Biophys Acta, Mar 2015
UNLABELLED: Here we investigated the effect of disruption of plasma membrane integrity by cholesterol depletion on thyrotropin-releasing hormone receptor (TRH-R) surface mobility in HEK293 cells stably expressing TRH-R-eGFP fusion protein (VTGP cells).
Loss of basal and TRH-stimulated Tshb expression in dispersed pituitary cells.
Stojilkovic et al., São Paulo, Brazil. In Endocrinology, 2015
This study addresses the in vivo and in vitro expression pattern of three genes that are operative in the thyrotroph subpopulation of anterior pituitary cells: glycoprotein α-chain (Cga), thyroid-stimulating hormone β-chain (Tshb), and TRH receptor (Trhr).
Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795, and ACSL1 rs6552828.
Lucia et al., Chiba, Japan. In Front Aging Neurosci, 2014
Among them are rs7832552 in the thyrotropin-releasing hormone receptor (TRHR) gene, rs1800795 in the interleukin-6 (IL6) gene and rs6552828 in the coenzyme A synthetase long-chain 1 (ACSL1) gene.
Hypothalamic-pituitary thyroid axis alterations in female mice with deletion of the neuromedin B receptor gene.
Pazos-Moura et al., Rio de Janeiro, Brazil. In Regul Pept, 2014
NBR-KO mice exhibited a 56% higher increase in serum TSH in response to an acute single intraperitoneal injection of TRH concomitant with a non-significant increase in pituitary TRH receptor (Trhr) mRNA at basal state.
Neonatal screening and a new cause of congenital central hypothyroidism.
Ishizu et al., Sapporo, Japan. In Ann Pediatr Endocrinol Metab, 2014
Autosomal recessive TSH deficiency and thyrotropin-releasing hormone receptor-inactivating mutations are known to be genetic causes of C-CH presenting in the absence of other syndromes.
Central hypothyroidism in children.
Moreno et al., Madrid, Spain. In Endocr Dev, 2013
At the hypothalamic level no gene defects causing CCH have yet been identified in humans, but pituitary (thyrotrope)-selective genes encoding the TSH-releasing hormone (TRH) receptor (TRHR), the TSH β-subunit (TSHB) and, recently, the immunoglobulin superfamily factor 1 (IGSF1) are genes involved in isolated central hypothyroidism.
Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels.
Gershengorn et al., Bethesda, United States. In Faseb J, 2012
We suggest that persistent signaling by TRHRs is exhibited when sufficient levels of agonist/receptor/G-protein complexes are established and maintained and that TRH-R2 forms and maintains these complexes more efficiently than TRH-R1.
Identification of a preassembled TRH receptor-G(q/11) protein complex in HEK293 cells.
Novotny et al., Praha, Czech Republic. In Cell Struct Funct, 2011
The precoupling of receptors with their cognate G-proteins can contribute to faster G-protein activation and subsequent signal transfer into the cell interior.
Co-localization of TRHR1 and LepRb receptors on neurons in the hindbrain of the rat.
Hermann et al., Baton Rouge, United States. In Brain Res, 2010
Co-localization of LepRb and TRHR1 is not observed on individual fibers in the hindbrain, but these two fiber types co-mingle in vagal and reticular nuclei.
Importance of regions outside the cytoplasmic tail of G-protein-coupled receptors for phosphorylation and dephosphorylation.
Hinkle et al., Rochester, United States. In Biochem J, 2010
Data show that interactions of TRHR with GRKs and phosphatases are determined not simply by the amino acid sequences of the substrates, but by regions outside the cytoplasmic tails.
Role of helix 8 of the thyrotropin-releasing hormone receptor in phosphorylation by G protein-coupled receptor kinase.
Hinkle et al., Rochester, United States. In Mol Pharmacol, 2010
A mutation in thyrotropin-releasing hormone receptor almost completely prevented receptor phosphorylation.
Mechanisms related to the pathophysiology and management of central hypothyroidism.
Mori et al., Japan. In Nat Clin Pract Endocrinol Metab, 2008
In addition, mutations in genes, such as TRHR, POU1F1, PROP1, HESX1, SOX3, LHX3, LHX4 and TSHB, have been associated with CH.
Thyrotropin-releasing hormone and its receptors--a hypothesis for binding and receptor activation.
Gershengorn et al., Bethesda, United States. In Pharmacol Ther, 2007
Thyrotropin-releasing hormone (TRH), a tripeptide, exerts its biological effects through stimulation of cell-surface receptors, TRH-R, belonging to the superfamily of G protein-coupled receptors (GPCR).
[Congenital central hypothyroidism due to the mutations of the thyrotropin-releasing hormone receptor gene].
Mori et al., In Nihon Rinsho, 2002
A patient with congenital central hypothyroidism due to the mutations of the thyrotropin-releasing hormone receptor gene has been reported by Collu, et al: in 1997.
Ectopic expression of thyrotropin releasing hormone (TRH) receptors in liver modulates organ function to regulate blood glucose by TRH.
Crystal et al., New York City, United States. In Nat Genet, 1996
We now show that the normal ligand-receptor regulators of blood glucose in the liver can be bypassed using an adenovirus vector expressing the mouse pituitary thyrotropin releasing hormone receptor (TRHR) cDNA ectopically in rat liver in vivo.
Molecular and cellular biology of thyrotropin-releasing hormone receptors.
Osman et al., New York City, United States. In Physiol Rev, 1996
Thyrotropin-releasing hormone (TRH) receptor (TRH-R) complementary DNAs have been cloned from several species.
Decreased TRH receptor mRNA activity precedes homologous downregulation: assay in oocytes.
Gershengorn et al., New York City, United States. In Science, 1988
The mechanism of TRH-R downregulation was studied by monitoring TRH-evoked depolarizing currents in Xenopus oocytes injected with GH3 cell RNA as a bioassay for TRH-R messenger RNA (mRNA) activity.
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